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dc.contributor.authorRodríguez-Barbeito, P.
dc.contributor.authorDíaz-Botana, P.
dc.contributor.authorGago-Arias, A.
dc.contributor.authorFeijoo, M.
dc.contributor.authorNeira, S.
dc.contributor.authorGuiu Souto, Jacobo|Lopez-Pouso, O.
dc.contributor.authorGómez Caamaño, Antonio 
dc.contributor.authorPardo-Montero, J.
dc.date.accessioned2021-12-10T08:59:24Z
dc.date.available2021-12-10T08:59:24Z
dc.date.issued2019
dc.identifier.issn0008-5472
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/31641030es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/15796
dc.description.abstractThere is increasing evidence that high doses of radiotherapy, like those delivered in stereotactic body radiotherapy (SBRT), trigger indirect mechanisms of cell death. Such effect seems to be two-fold. High doses may trigger an immune response and may cause vascular damage, leading to cell starvation and death. Development of mathematical response models, including indirect death, may help clinicians to design SBRT optimal schedules. Despite increasing experimental literature on indirect tumor cell death caused by vascular damage, efforts on modeling this effect have been limited. In this work, we present a biomathematical model of this effect. In our model, tumor oxygenation is obtained by solving the reaction-diffusion equation; radiotherapy kills tumor cells according to the linear-quadratic model, and also endothelial cells (EC), which can trigger loss of functionality of capillaries. Capillary death will affect tumor oxygenation, driving nearby tumor cells into severe hypoxia. Capillaries can recover functionality due to EC proliferation. Tumor cells entering a predetermined severe hypoxia status die according to a hypoxia-death model. This model fits recently published experimental data showing the effect of vascular damage on surviving fractions. It fits surviving fraction curves and qualitatively reproduces experimental values of percentages of functional capillaries 48 hours postirradiation, and hypoxic cells pre- and 48 hours postirradiation. This model is useful for exploring aspects of tumor and EC response to radiotherapy and constitutes a stepping stone toward modeling indirect tumor cell death caused by vascular damage and accounting for this effect during SBRT planning. SIGNIFICANCE: A novel biomathematical model of indirect tumor cell death caused by vascular radiation damage could potentially help clinicians interpret experimental data and design better radiotherapy schedules.en
dc.language.isoenges
dc.subject.meshCapillaries*
dc.subject.meshApoptosis*
dc.subject.meshRadiosurgery*
dc.subject.meshCell Hypoxia*
dc.subject.meshHumans*
dc.subject.meshTreatment Outcome*
dc.subject.meshEndothelium*
dc.subject.meshCell Proliferation*
dc.subject.meshNeoplasms*
dc.subject.meshEndothelial Cells*
dc.titleA model of indirect cell death caused by tumor vascular damage after high-dose radiotherapyen
dc.typeArtigoes
dc.authorsophosRodríguez-Barbeito, P.
dc.authorsophosDíaz-Botana, P.
dc.authorsophosGago-Arias, A.
dc.authorsophosFeijoo, M.
dc.authorsophosNeira, S.
dc.authorsophosGuiu-Souto, J.
dc.authorsophosLopez-Pouso, O.
dc.authorsophosGomez-Caamaño, A.
dc.authorsophosPardo-Montero, J.
dc.identifier.doi10.1158/0008-5472.CAN-19-0181
dc.identifier.pmid31641030
dc.identifier.sophos31830
dc.issue.number23es
dc.journal.titleCANCER RESEARCHes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Radiofísica e protección radiolóxicaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Oncoloxía Radioterápicaes
dc.page.initial6044es
dc.page.final6053es
dc.relation.publisherversionhttps://cancerres.aacrjournals.org/content/canres/79/23/6044.full.pdfes
dc.rights.accessRightsembargoedAccesses
dc.subject.decsresultado del tratamiento*
dc.subject.decsapoptosis*
dc.subject.decsradiocirugía*
dc.subject.decscapilares*
dc.subject.decsproliferación celular*
dc.subject.decshumanos*
dc.subject.decshipoxia celular*
dc.subject.decsneoplasias*
dc.subject.decsendotelio*
dc.subject.decscélulas endoteliales*
dc.subject.keywordCHUSes
dc.typefidesArtículo Originales
dc.typesophosArtículo Originales
dc.volume.number79es


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