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dc.contributor.authorAngelats L
dc.contributor.authorGarcía Campelo, María del Rosario 
dc.contributor.authorBernabe Caro R
dc.contributor.authorArriola Aperribay E
dc.contributor.authorCalvo de Juan V
dc.contributor.authorBarba Joaquín A
dc.contributor.authorVinolas Segarra N
dc.contributor.authorGil Moreno MDLL
dc.contributor.authorVilà Martinez L
dc.contributor.authorJuan Vidal OJ
dc.contributor.authorVilariño Quintela N
dc.contributor.authorCobo M
dc.contributor.authorSais E
dc.contributor.authorDomine Gomez M
dc.contributor.authorFernández Nuñez, Natalia 
dc.contributor.authorCoves Sarto J
dc.contributor.authorMarse Fabregat R
dc.contributor.authorEsteve Gomez AM
dc.contributor.authorRodríguez-Abreu D
dc.contributor.authorCarcereny Costa E
dc.date.accessioned2021-12-10T09:01:59Z
dc.date.available2021-12-10T09:01:59Z
dc.date.issued2019
dc.identifier.issn0923-7534
dc.identifier.urihttp://hdl.handle.net/20.500.11940/15835
dc.description.abstractBackground: CNS is a common site of metastases in patients with ALK-positive NSCLC. CNS metastases are associated with a number of deleterious effects, such as reduction in quality of life. However, the relationship between brain metastases and prognosis remains unclear. We aimed to evaluate the effect of CNS metastases on overall survival (OS) in a multicenter cohort of Spanish ALK-positive NSCLC patients diagnosed between 2008 and 2017. Methods: We included patients with stage IV at diagnoses, followed up to April 2018; OS (months [m]) was estimated with the Kaplan-Meier method. Survival curves were compared between groups of patients using the log-rank test. Hazard risk (HR) to death was estimated with multivariable Cox model. Results: Out of 163 patients in the cohort, a total of 116 were evaluated, with a median of follow-up of 29.2 m and 59 deaths reported. Characteristics at diagnosis were a median age of 58 years, 50% female, 58.6% never-smokers, 54.3% with comorbidities, PS by ECOG 0-1 93.1%. CNS metastases (median number of lesions 6) were present in 43.1% of patients and 34% of patients with CNS metastases were treated with local therapy (11.8 % local radiotherapy and 76.5% holocraneal radiotherapy). ALK inhibitors as first line and second line treatment were administered to 45.5% and 78.6% of patients, respectively. The median OS was 39 months; OS in patients with CNS metastases at diagnosis was 34.4 m and 39.0 m in those without CNS metastases at diagnosis (p=.9). In patients without CNS metastases at baseline (n=60), 22 developed CNS, with a median OS greater than in those without CNS metastases during follow-up, although the difference is not significant (45.5 m vs 33.3 m; p=.9). There were 81 patients who presented with metastases in more than one organ and 33 patients with metastases in a single organ. The risk of death increased as the number of metastatic organs at diagnoses increased (HR=1.26, p=.0305), with worse OS in those presenting with liver metastases at diagnoses (21.1%, OS: 20 m), compared to those without tumor involvement (OS: 45.4 m; p =.008). Conclusions: OS was similar for ALK-positive NSCLC patients with and without CNS metastases at diagnoses. OS was worse as the number of metastatic organs at diagnosis increased, with liver metastases being associated with the highest risk of mortality.en
dc.language.isoenges
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleEffect of central nervous system (CNS) metastases in a real-world multicenter cohort study of Spanish ALK-positive non-small cell lung cancer (NSCLC) patients (p)en
dc.typePublicación de congresoes
dc.authorsophosAngelats L, Garcia Campelo MR, Bernabe Caro R, Arriola Aperribay E, Calvo de Juan V, Barba Joaquín A, Vinolas Segarra N, Gil Moreno MDLL, Vilà Martinez L, Juan Vidal OJ, Vilariño Quintela N, Cobo M, Sais E, Domine Gomez M, Fernandez Nuñez N, Coves Sarto J, Marse Fabregat R, Esteve Gomez AM, Rodríguez-Abreu D, Carcereny Costa E
dc.identifier.doi10.1093/annonc/mdz063.039
dc.identifier.sophos32188
dc.issue.numberSuppl 2es
dc.journal.titleANNALS OF ONCOLOGYes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Lugo, Cervo e Monforte de lemos - Complexo Hospitalario Universitario Lucus Augusti::Oncoloxía médicaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de A Coruña - Complexo Hospitalario Universitario de A Coruña::Oncoloxía médicaes
dc.page.initialii53es
dc.page.finalii53es
dc.relation.publisherversionhttps://www.annalsofoncology.org/article/S0923-7534(19)30090-0/pdfes
dc.rights.accessRightsopenAccesses
dc.subject.keywordHULAes
dc.subject.keywordCHUACes
dc.typefidesComunicaciones a congresoses
dc.typesophosComunicaciones a congresoses
dc.volume.number30es


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