Show simple item record

dc.contributor.authorMartínez Guitian, Marta
dc.contributor.authorVázquez Ucha, Juan Carlos
dc.contributor.authorAlvarez Fraga, Laura
dc.contributor.authorConde Pérez, Kelly
dc.contributor.authorLasarte Monterrubio, Cristina
dc.contributor.authorVallejo Vidal, Juan Andrés
dc.contributor.authorBou Arévalo, Germán 
dc.contributor.authorPoza Dominguez, Margarita
dc.contributor.authorBECEIRO CASAS, ALEJANDRO JOSE 
dc.date.accessioned2022-01-25T12:16:29Z
dc.date.available2022-01-25T12:16:29Z
dc.date.issued2019
dc.identifier.issn2235-2988
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/31555607es
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727670/pdf/fcimb-09-00310.pdfes
dc.identifier.urihttp://hdl.handle.net/20.500.11940/15909
dc.description.abstractAcinetobacter baumannii is currently considered one of the most problematic nosocomial microorganisms. In the present work the hisF gene from the ATCC 17978 strain and the AbH12O-A2 clinical isolate of A. baumannii was found over-expressed during the course of murine pneumonia infections. The study demonstrated that the A. baumannii ATCC 17978 mutant strain lacking the hisF gene induces a sub-lethal pneumonia infection in mice, while the complemented mutant strain increased its virulence. This histidine auxotroph mutant showed an increase on IL-6 secretion and leukocytes recruitment during infections. Furthermore, data revealed that the hisF gene, implicated in the innate immunity and inflammation, is involved in virulence during a pneumonia infection, which may partly explain the ability of this strain to persist in the lung. We suggest that HisF, essential for full virulence in this pathogen, should be considered a potential target for developing new antimicrobial therapies against A. baumannii. Importance Nosocomial pathogens such as A. baumannii are able to acquire and develop multi-drug resistance and represent an important clinical and economic problem. There is therefore an urgent need to find new therapeutic targets to fight against A. baumannii. In the present work, the potential of HisF from A. baumannii as a therapeutic target has been addressed since this protein is involved in the innate inmunity and the inflamatory response and seems essential to develop a pneumonia in mice. This work lays the groundwork for designing antimicrobial therapies that block the activity of HisF.en
dc.language.isoenges
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.meshVirulence Factors *
dc.subject.meshGene Knockout Techniques *
dc.subject.meshMice *
dc.subject.meshTranscriptome *
dc.subject.meshPneumonia *
dc.subject.meshAnimals *
dc.subject.meshInterleukin-6 *
dc.subject.meshVirulence *
dc.subject.meshLung *
dc.subject.meshAminohydrolases *
dc.subject.meshGenes *
dc.subject.meshHumans *
dc.subject.meshMicrobial Sensitivity Tests *
dc.subject.meshDrug Resistance *
dc.subject.meshAcinetobacter baumannii *
dc.titleInvolvement of HisF in the Persistence of Acinetobacter baumannii During a Pneumonia Infectionen
dc.typeArtigoes
dc.identifier.doi10.3389/fcimb.2019.00310
dc.identifier.pmid31555607
dc.identifier.sophos32309
dc.journal.titleFrontiers in Cellular and Infection Microbiologyes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Biomédica da Coruña (INIBIC)es
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de A Coruña - Complexo Hospitalario Universitario de A Coruña::Microbioloxíaes
dc.rights.accessRightsopenAccesses
dc.subject.decsinterleucina-6 *
dc.subject.decspruebas de sensibilidad microbiana *
dc.subject.decsfactores de virulencia *
dc.subject.decsanimales *
dc.subject.decsresistencia a medicamentos *
dc.subject.decsvirulencia *
dc.subject.decsAcinetobacter baumannii *
dc.subject.decsneumonía *
dc.subject.decsgenes *
dc.subject.decstranscriptoma *
dc.subject.decshumanos *
dc.subject.decspulmón *
dc.subject.decstécnicas de inactivación génica *
dc.subject.decsaminohidrolasas *
dc.subject.decsratones *
dc.subject.keywordINIBICes
dc.subject.keywordCHUACes
dc.typefidesArtículo Originales
dc.typesophosArtículo Originales
dc.volume.number9es


Files in this item

This item appears in the following Collection(s)

Show simple item record

Atribución 4.0 Internacional
Except where otherwise noted, this item's license is described as Atribución 4.0 Internacional