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dc.contributor.authorRodríguez Osorio, Iria 
dc.contributor.authorMena de Cea, Alvaro 
dc.contributor.authorMeijide Miguez, Hector M
dc.contributor.authorMorano Amado, Luis 
dc.contributor.authorDelgado Blanco, Manuel 
dc.contributor.authorCid Silva, Purificación 
dc.contributor.authorMargusino Framiñán, Luis 
dc.contributor.authorPedreira Andrade, José Domingo 
dc.contributor.authorCastro Iglesias, Angeles 
dc.date.accessioned2022-01-25T12:18:22Z
dc.date.available2022-01-25T12:18:22Z
dc.date.issued2019
dc.identifier.issn1932-6203
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546209/pdf/pone.0217052.pdfes
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/31158237es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/15935
dc.description.abstractBACKGROUND: Direct-acting antivirals (DAAs) are effective in patients aged >/=65 years. However, little is known about the effects of DAAs on survival, liver decompensation and development of hepatocellular carcinoma (HCC). OBJECTIVE: To compare the incidence of liver-related events and mortality between patients aged >/=65 and <65 years. METHODS: Prospective study comparing patients aged >/=65 and <65 years treated with DAAs. The incidence of liver-related events and mortality, and HCC was compared between age groups. RESULTS: Five hundred patients (120 aged >/=65 and 380 aged <65 years) were included. The incidence of liver-related events was 2.62 per 100 patient-years (py) in older and 1.41/100 py in younger patients. All-cause mortality was 3.89 and 1.27/100 py in older and younger patients, respectively. The respective liver-related mortality rates were 1.12 and 0.31/100 py. In patients with cirrhosis (stage F4), all-cause mortality (P = 0.283) and liver-related mortality (P = 0.254) did not differ between groups. All five liver-related deaths were related to multifocal HCC. The incidence of HCC was 1.91 and 1.43 per 100 py in the older and younger groups, respectively (P = 0.747). The diagnosis of HCC was 8 months after the end of treatment. CONCLUSIONS: The incidence of liver-related events and liver-related mortality was low in older people treated with DAAs and was similar to that in younger patients. The extra mortality in people aged >/=65 years treated with DAAs seems to be secondary to non-liver-related causes. These results support the utilization of DAAs in patients aged >/=65 years.en
dc.language.isoenges
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.meshHepatitis C*
dc.subject.meshCarcinoma*
dc.subject.meshMiddle Aged*
dc.subject.meshHumans*
dc.subject.meshCarcinogenesis*
dc.subject.meshLiver*
dc.subject.meshLiver Neoplasms*
dc.subject.meshAged*
dc.subject.meshAntiviral Agents*
dc.titleLiver-related events and mortality among elderly patients with advanced chronic hepatitis C treated with direct-acting antiviralses
dc.typeArtigoes
dc.identifier.doi10.1371/journal.pone.0217052
dc.identifier.pmid31158237
dc.identifier.sophos32416
dc.issue.number6es
dc.journal.titlePLoS Onees
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de A Coruña - Complexo Hospitalario Universitario de A Coruña::Dixestivoes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de A Coruña - Complexo Hospitalario Universitario de A Coruña::Farmaciaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de A Coruña - Complexo Hospitalario Universitario de A Coruña::Medicina Internaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Vigo - Complexo Hospitalario Universitario de Vigo::Medicina Internaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Biomédica da Coruña (INIBIC)es
dc.rights.accessRightsopenAccesses
dc.subject.decscarcinoma*
dc.subject.decsanciano*
dc.subject.decsantivíricos*
dc.subject.decshígado*
dc.subject.decshepatitis C*
dc.subject.decsmediana edad*
dc.subject.decshumanos*
dc.subject.decsneoplasias hepáticas*
dc.subject.decscarcinogénesis*
dc.subject.keywordCHUACes
dc.subject.keywordCHUVIes
dc.subject.keywordINIBICes
dc.typefidesArtículo Originales
dc.typesophosArtículo Originales
dc.volume.number14es


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Atribución 4.0 Internacional
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