Behcet's disease and genetic interactions between HLA-B*51 and variants in genes of autoinflammatory syndromes.
Burillo-Sanz, Sergio; Montes-Cano, Marco-Antonio; Garcia-Lozano, Jose-Raul; Olivas-Martinez, Israel; Ortego-Centeno, Norberto; Garcia-Hernandez, Francisco-Jose; Espinosa, Gerard; Graña Gil, Genaro; Sanchez-Burson, Juan; Julia, Maria Rosa; Solans, Roser; Blanco, Ricardo; Barnosi-Marin, Ana-Celia; Gomez de la Torre, Ricardo; Fanlo, Patricia; Rodriguez-Carballeira, Monica; Rodriguez-Rodriguez, Luis; Camps, Teresa; Castaneda, Santos; Alegre-Sancho, Juan-Jose; Martin, Javier; Gonzalez-Escribano, Maria Francisca
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Fecha de publicación
2019Título de revista
Scientific Reports
Tipo de contenido
Artigo
DeCS
proteínas citoesqueléticas | péptidos y proteínas de señalización intracelular | mediadores de la inflamación | genotipo | síndrome de Behçet | humanos | estudios de cohortes | adulto | enfermedades autoinflamatorias hereditarias | antígenos HLA-B | predisposición genética a la enfermedadMeSH
Adult | Humans | Intracellular Signaling Peptides and Proteins | Behcet Syndrome | Cytoskeletal Proteins | Hereditary Autoinflammatory Diseases | Genetic Predisposition to Disease | Genotype | Inflammation Mediators | HLA-B Antigens | Cohort StudiesResumen
Behcet's disease (BD) is an immune-mediated systemic disorder with a well-established genetic base. In a previous study, using a next generation sequencing approach, we found many rare variants and some functional polymorphisms in genes related to autoinflammatory syndromes (AID): CECR1, MEFV, MVK, NLRP3, NOD2, PSTPIP1 and TNFRSF1A in our BD cohort. Our strategy did not allow us to establish either number of patients with variants, proportion of individuals accumulating them or relationship with other genetic factors. With the goal to answer these questions, the individual samples were sequenced. Additionally, three functional polymorphisms: NLRP3 p.Gln703Lys, NOD2 p.Arg702Trp and p.Val955Ile were genotyped using TaqMan assays. A total of 98 patients (27.6%) carried at least one rare variant and 13 of them (3.7%) accumulated two or three. Functional regression model analysis suggests epistatic interaction between B51 and MEFV (P = 0.003). A suggestive protective association of the minor allele of NOD2 p.Arg702Trp (P = 0.01) was found in both, B51 positive and negative individuals. Therefore, a high percentage of patients with BD have rare variants in AID genes. Our results suggest that the association of MEFV with BD could be modulated by the HLA molecules; whereas the protective effect of NOD2 p.Arg702Trp would be independent of HLA.
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