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dc.contributor.authorBlanco Aparicio, Marina 
dc.contributor.authorSaleta Canosa, Jesús Luis
dc.contributor.authorValiño Lopez, Paz 
dc.contributor.authorMartin Egaña, Teresa
dc.contributor.authorVIDAL GARCIA, IRIA 
dc.contributor.authorMontero Martínez, Carmen 
dc.date.accessioned2022-01-27T10:39:48Z
dc.date.available2022-01-27T10:39:48Z
dc.date.issued2019
dc.identifier.issn1479-9723
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/31480862es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/15953
dc.description.abstractThe persistent isolation of Pseudomonas aeruginosa in the airways of non-cystic fibrosis bronchiectasis (NCFB) patients is associated with a worsening of the symptoms, increase of exacerbations, poor quality of life and functional impairment. The objective of this study was the analysis of the eradication rate of P. aeruginosa in the sputum of patients with NCFB treated with inhaled colistin and the effects of the treatment in the exacerbations. This was a prospective, cohort, study of 67 NCFB patients treated with inhaled colistin at the Hospital of A Coruna (Spain). We recorded dyspnoea, exacerbations, lung function and sputum cultures of P. aeruginosa in the patients. The mean age of the patients was 67.25 +/- 14.6 years (59.7% male). The percentages of eradication of P. aeruginosa in sputum at 3, 6, 9 and 12 months were 61.2%, 50.7%, 43.3% and 40.3%, respectively. We observed a significant decrease in exacerbations after 1 year of colistin treatment (1.98 +/- 3.62) versus the previous year (3.40 +/- 4.21, p < 0.001). We conclude that treatment with inhaled colistin in patients with NCFB and P. aeruginosa in sputum can achieve high rates of eradication even in patients with several previous positive cultures, as well as a significant decrease of exacerbations and hospital admissions.en
dc.language.isoenges
dc.rightsAtribución-NoComercial 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subject.meshAdult*
dc.subject.meshMiddle Aged*
dc.subject.meshAdolescent*
dc.subject.meshForced Expiratory Volume*
dc.subject.meshAnti-Bacterial Agents*
dc.subject.meshHospitalization*
dc.subject.meshHumans*
dc.subject.meshYoung Adult*
dc.subject.meshProspective Studies*
dc.subject.meshColistin*
dc.subject.meshSputum*
dc.subject.meshBronchiectasis*
dc.subject.meshDisease Progression*
dc.subject.meshDyspnea*
dc.subject.meshPseudomonas aeruginosa*
dc.subject.meshAged*
dc.subject.meshVital Capacity*
dc.subject.meshPseudomonas Infections*
dc.titleEradication of Pseudomonas aeruginosa with inhaled colistin in adults with non-cystic fibrosis bronchiectasis.en
dc.typeArtigoes
dc.identifier.doi10.1177/1479973119872513
dc.identifier.pmid31480862
dc.identifier.sophos32612
dc.journal.titleChron Respir Dises
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de A Coruña - Complexo Hospitalario Universitario de A Coruña::Medicina Preventivaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de A Coruña - Complexo Hospitalario Universitario de A Coruña::Neumoloxíaes
dc.relation.publisherversionhttps://journals.sagepub.com/doi/pdf/10.1177/1479973119872513es
dc.rights.accessRightsopenAccesses
dc.subject.decsbronquiectasia*
dc.subject.decsvolumen espiratorio forzado*
dc.subject.decsestudios prospectivos*
dc.subject.decsmediana edad*
dc.subject.decscapacidad vital*
dc.subject.decsadulto*
dc.subject.decsprogresión de la enfermedad*
dc.subject.decsantibacterianos*
dc.subject.decsesputo*
dc.subject.decsanciano*
dc.subject.decsdisnea*
dc.subject.decsPseudomonas aeruginosa*
dc.subject.decsinfecciones por Pseudomonas*
dc.subject.decshospitalización*
dc.subject.decsadulto joven*
dc.subject.decshumanos*
dc.subject.decsadolescente*
dc.subject.decscolistina*
dc.subject.keywordCHUACes
dc.typefidesArtículo Originales
dc.typesophosArtículo Originales
dc.volume.number16.es


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