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dc.contributor.authorVázquez Mourelle, Raquel
dc.contributor.authorCarracedo-Martinez, Eduardo
dc.contributor.authorFigueiras, Adolfo
dc.date.accessioned2022-01-27T10:41:54Z
dc.date.available2022-01-27T10:41:54Z
dc.date.issued2019
dc.identifier.issn1748-5908
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657080/pdf/13012_2019_Article_924.pdfes
dc.identifier.urihttp://hdl.handle.net/20.500.11940/15985
dc.description.abstractBACKGROUND: The study covered in- and out-of-hospital care in a region in north-western Spain. The intervention evaluated took the form of a change in the hospital drugs formulary. Before the intervention, the formulary contained four of the five low molecular weight heparins (LMWHs) marketed in Spain. The intervention consisted of withdrawing two LMWHs (bemiparin and dalteparin) from the formulary and restricting the use of another (tinzaparin), leaving only enoxaparin as an unrestricted prescription LMWH. Accordingly, the aim of this study was to evaluate the effect on in- and outpatient drug prescriptions of removing and restricting the use of several LMWHs in a hospital drugs formulary. METHODS: We used a natural, before-after, quasi-experimental design with a control group and monthly data from January 2011 to December 2016. Based on data drawn from official Public Health Service sources, the following dependent variables were extracted: defined daily doses (DDD) per 1000 inhabitants per day (DDD/TID), DDD per 100 stays per day, and expenditure per DDD. RESULTS: The two compounds that were removed from the formulary registered an immediate decrease at both an intra- and out-of-hospital level (66.6% and 55.6% for bemiparin and 73.0% and 92.2% for dalteparin, respectively); similarly, the compound that was restricted also registered an immediate decrease (36.1% and 9.0% at the in- and outpatient levels, respectively); in contrast, the remaining LMWH (enoxaparin) registered an immediate, significant increase at both levels (44.9% and 32.6%, respectively). The intervention led to an immediate reduction of 6.8% and a change in trend in out-of-hospital cost/DDD; it also avoided an expenditure of euro477,317.1 in the 21 months following the intervention. CONCLUSIONS: The results indicate that changes made in a hospital drugs formulary towards more efficient medications may lead to better use of pharmacotherapeutic resources in its health catchment area.en
dc.language.isoenges
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.meshHeparin*
dc.subject.meshPrescription Drugs*
dc.subject.meshHumans*
dc.subject.meshDrug Prescriptions*
dc.subject.meshFormularies*
dc.subject.meshDalteparin*
dc.subject.meshEnoxaparin*
dc.titleImpact of removal and restriction of me-too medicines in a hospital drug formulary on in- and outpatient drug prescriptions: interrupted time series design with comparison group.en
dc.typeArtigoes
dc.identifier.doi10.1186/s13012-019-0924-0 [pii]
dc.identifier.pmid31340835
dc.identifier.sophos33003
dc.issue.number1es
dc.journal.titleImplementation Sciencees
dc.organizationConsellería de Sanidade::Dirección Xeral de Saúde Pública::Subdirección Xeral de Información sobre Saúde e Epidemioloxíaes
dc.rights.accessRightsopenAccesses
dc.subject.decsdalteparina*
dc.subject.decsenoxaparina*
dc.subject.decsformularios farmacéuticos*
dc.subject.decshumanos*
dc.subject.decsprescripciones de medicamentos*
dc.subject.decsheparina*
dc.subject.decsmedicamentos por prescripción*
dc.subject.keywordDXSPes
dc.typefidesArtículo Originales
dc.typesophosArtículo Originales
dc.volume.number14es


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Atribución 4.0 Internacional
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