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dc.contributor.authorCaruncho, H. J.
dc.contributor.authorRivera Baltanas, Tania
dc.contributor.authorRomay-Tallon, R.
dc.contributor.authorKalynchuk, L. E.
dc.contributor.authorOlivares Diez, José Manuel 
dc.date.accessioned2022-01-28T11:51:12Z
dc.date.available2022-01-28T11:51:12Z
dc.date.issued2019
dc.identifier.issn1663-9812
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/30930773es
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423346/pdf/fphar-10-00190.pdfes
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/30930773es
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423346/pdf/fphar-10-00190.pdfes
dc.identifier.urihttp://hdl.handle.net/20.500.11940/15998
dc.description.abstractThere is an utmost necessity of developing novel biomarkers of depression that result in a more efficacious use of current antidepressant drugs. The present report reviews and discusses a recent series of experiments that focused on analysis of membrane protein clustering in peripheral lymphocytes as putative biomarkers of therapeutic efficacy for major depressive disorder. This review recapitulates how the ideas were originated, and the main findings demonstrated that analysis of serotonin transporter and serotonin 2 A receptor clustering in peripheral lymphocytes of naive depression patients resulted in a discrimination of two subpopulations of depressed patients that showed a differential response upon 8 weeks of antidepressant treatment. The paper also reviews the usefulness of animal models of depression for an initial evaluation of membrane protein clustering in lymphocytes, which provides a screening tool to determine additional proteins to be further evaluated in depression patients. Finally, the present review provides a brief discussion of the general field of biomarkers of depression in relation to therapeutic outcomes and suggests additional ideas to provide extra value to the reviewed studies.en
dc.language.isoenges
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titlePatterns of Membrane Protein Clustering in Peripheral Lymphocytes as Predictors of Therapeutic Outcomes in Major Depressive Disorderen
dc.typeArtigoes
dc.authorsophosCaruncho, H. J.;Rivera-Baltanas, T.;Romay-Tallon, R.;Kalynchuk, L. E.;Olivares, J. M.
dc.identifier.doi10.3389/fphar.2019.00190
dc.identifier.pmid30930773
dc.identifier.sophos33156
dc.journal.titleFront Pharmacoles
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Vigo - Complexo Hospitalario Universitario de Vigo::Psiquiatríaes
dc.page.initial190es
dc.rights.accessRightsopenAccesses
dc.subject.keywordCHUVIes
dc.typefidesArtículo de Revisiónes
dc.typesophosArtículo de Revisiónes
dc.volume.number10.es


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Atribución 4.0 Internacional
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