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dc.contributor.authorCamacho Encina, María
dc.contributor.authorBalboa Barreiro, Vanesa
dc.contributor.authorRego Pérez, Ignacio 
dc.contributor.authorPicchi Figueira, Florencia Cristina
dc.contributor.authorJ., Vanduin
dc.contributor.authorJ., Qiu
dc.contributor.authorM., Fuentes
dc.contributor.authorOREIRO VILLAR, NATIVIDAD 
dc.contributor.authorJ., Labaer
dc.contributor.authorRuiz Romero, Cristina 
dc.contributor.authorBLANCO GARCIA, FRANCISCO JAVIER 
dc.date.accessioned2022-01-28T11:52:49Z
dc.date.available2022-01-28T11:52:49Z
dc.date.issued2019
dc.identifier.issn0003-4967
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/31471297es]
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/31471297es]bi
dc.identifier.urihttp://hdl.handle.net/20.500.11940/16022
dc.description.abstractOBJECTIVE: To find autoantibodies (AAbs) in serum that could be useful to predict incidence of radiographic knee osteoarthritis (KOA). DESIGN: A Nucleic-acid Programmable Protein Arrays (NAPPA) platform was used to screen AAbs against 2125 human proteins in sera at baseline from participants free of radiographic KOA belonging to the incidence and non-exposed subcohorts of the Osteoarthritis Initiative (OAI) who developed or not, radiographic KOA during a follow-up period of 96 months. NAPPA-ELISA were performed to analyse reactivity against methionine adenosyltransferase two beta (MAT2beta) and verify the results in 327 participants from the same subcohorts. The association of MAT2beta-AAb levels with KOA incidence was assessed by combining several robust biostatistics analysis (logistic regression, Receiver Operating Characteristic and Kaplan-Meier curves). The proposed prognostic model was replicated in samples from the progression subcohort of the OAI. RESULTS: In the screening phase, six AAbs were found significantly different at baseline in samples from incident compared with non-incident participants. In the verification phase, high levels of MAT2beta-AAb were significantly associated with the future incidence of KOA and with an earlier development of the disease. The incorporation of this AAb in a clinical model for the prognosis of incident radiographic KOA significantly improved the identification/classification of patients who will develop the disorder. The usefulness of the model to predict radiographic KOA was confirmed on a different OAI subcohort. CONCLUSIONS: The measurement of AAbs against MAT2beta in serum might be highly useful to improve the prediction of OA development, and also to estimate the time to incidence.en
dc.language.isoenges
dc.rightsAtribución-NoComercial 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subject.meshPredictive Value of Tests*
dc.subject.meshRadiography*
dc.subject.meshMiddle Aged*
dc.subject.meshHumans*
dc.subject.meshAutoantibodies*
dc.subject.meshKnee Joint*
dc.subject.meshROC Curve*
dc.subject.meshEnzyme-Linked Immunosorbent Assay*
dc.subject.meshFollow-Up Studies*
dc.subject.meshEarly Diagnosis*
dc.subject.meshCase-Control Studies*
dc.subject.meshDisease Progression*
dc.subject.meshOsteoarthritis*
dc.subject.meshIncidence*
dc.titleDiscovery of an autoantibody signature for the early diagnosis of knee osteoarthritis: Data from the Osteoarthritis Initiativeen
dc.typeArtigoes
dc.authorsophosM., Camacho-Encina;V., Balboa-Barreiro;I., Rego-Perez;F., Picchi;J., Vanduin;J., Qiu;M., Fuentes;N., Oreiro;J., Labaer;C., Ruiz-Romero;F.J., Blanco
dc.identifier.doi10.1136/annrheumdis-2019-215325
dc.identifier.pmid31471297
dc.identifier.sophos33857
dc.issue.number12es
dc.journal.titleAnnals of the rheumatic diseaseses
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de A Coruña - Complexo Hospitalario Universitario de A Coruña:: Reumatoloxíaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Biomédica da Coruña (INIBIC)es
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de A Coruña - Complexo Hospitalario Universitario de A Coruña:: Epidemioloxíaes
dc.page.initial1699es
dc.page.final1705es
dc.relation.publisherversionhttps://ard.bmj.com/content/annrheumdis/78/12/1699.full.pdfes
dc.rights.accessRightsopenAccesses
dc.subject.decsestudios de casos y controles*
dc.subject.decscurva ROC*
dc.subject.decsautoanticuerpos*
dc.subject.decsincidencia*
dc.subject.decsestudios de seguimiento*
dc.subject.decspruebas de valores predictivos*
dc.subject.decsmediana edad*
dc.subject.decsprogresión de la enfermedad*
dc.subject.decsarticulación de la rodilla*
dc.subject.decsradiografía*
dc.subject.decsdiagnóstico precoz*
dc.subject.decshumanos*
dc.subject.decsosteoartritis*
dc.subject.decsenzimoinmunoanálisis por adsorción*
dc.subject.keywordCHUACes
dc.subject.keywordINIBICes
dc.typefidesArtículo Originales
dc.typesophosArtículo Originales
dc.volume.number78es


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