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dc.contributor.authorL., Jara-Palomares
dc.contributor.authorA., Hernando
dc.contributor.authorE., Tabernero
dc.contributor.authorMarcos Rodríguez, Pedro Jorge 
dc.contributor.authorP., Ruiz-Artacho
dc.contributor.authorA., Ballaz
dc.contributor.authorR., Yusen
dc.contributor.authorA., Agusti
dc.contributor.authorL., Bertoletti
dc.contributor.authorF., Couturaud
dc.contributor.authorM.V., Huisman
dc.contributor.authorD., Jimenez
dc.contributor.authorJ.L., Lobo
dc.contributor.authorM., Monreal
dc.contributor.authorR., Otero
dc.contributor.authorR.D., Yusen
dc.contributor.authorA., Muriel
dc.contributor.authorI., Guerassimova
dc.contributor.authorR., Morillo
dc.contributor.authorD., Barrios
dc.contributor.authorA., Quezada
dc.contributor.authorI., Gallego
dc.contributor.authorA., Vicente
dc.date.accessioned2022-02-01T12:59:38Z
dc.date.available2022-02-01T12:59:38Z
dc.date.issued2019
dc.identifier.issn0160-9289
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712316/pdf/CLC-42-346.pdfes
dc.identifier.urihttp://hdl.handle.net/20.500.11940/16052
dc.description.abstractINTRODUCTION: Some previous studies have suggested a high prevalence of pulmonary embolism (PE) during exacerbations of chronic obstructive pulmonary disease (ECOPD). The SLICE trial aims to assess the efficacy and safety of an active strategy for the diagnosis and treatment of PE (vs usual care) in patients hospitalized because of ECOPD. METHODS: SLICE is a phase III, prospective, international, multicenter, randomized, open-label, and parallel-group trial. A total of 746 patients hospitalized because of ECOPD will be randomized in a 1:1 fashion to receive either an active strategy for the diagnosis and anticoagulant treatment of PE or usual care (ie, standard care without any diagnostic test for diagnosing PE). The primary outcome is a composite of all-cause death, non-fatal (recurrent) venous thromboembolism (VTE), or readmission for ECOPD within 90 days after enrollment. Secondary outcomes are (a) death from any cause within 90 days after enrollment, (b) non-fatal (recurrent) VTE within 90 days after enrollment, (c) readmission within 90 days after enrollment, and (d) length of hospital stay. RESULTS: Enrollment started in September 2014 and is expected to proceed until 2020. Median age of the first 443 patients was 71 years (interquartile range, 64-78), and 26% were female. CONCLUSIONS: This multicenter trial will determine the value of detecting PEs in patients with ECOPD. This has implications for COPD patient morbidity and mortality. TRIAL REGISTRATION NUMBER: NCT02238639.en
dc.language.isoenges
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.meshThrombolytic Therapy*
dc.subject.meshAnticoagulants*
dc.subject.meshReproducibility of Results*
dc.subject.meshMiddle Aged*
dc.subject.meshHumans*
dc.subject.meshUltrasonography*
dc.subject.meshPulmonary Embolism*
dc.subject.meshMultidetector Computed Tomography*
dc.subject.meshMulticenter Studies as Topic*
dc.subject.meshProspective Studies*
dc.subject.meshRandomized Controlled Trials as Topic*
dc.subject.meshPractice Guidelines as Topic*
dc.subject.meshAged*
dc.titleThe rationale, design, and methods of a randomized, controlled trial to evaluate the efficacy and safety of an active strategy for the diagnosis and treatment of acute pulmonary embolism during exacerbations of chronic obstructive pulmonary diseaseen
dc.typeArtigoes
dc.contributor.authorcorpSLICE Investigators
dc.identifier.doi10.1002/clc.23161
dc.identifier.pmid30706520
dc.identifier.sophos34001
dc.issue.number3es
dc.journal.titleCLINICAL CARDIOLOGYes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de A Coruña - Complexo Hospitalario Universitario de A Coruña::Neumoloxíaes
dc.page.initial346es
dc.page.final351es
dc.rights.accessRightsopenAccesses
dc.subject.decsanciano*
dc.subject.decsestudios prospectivos*
dc.subject.decstratamiento trombolítico*
dc.subject.decsmediana edad*
dc.subject.decsanticoagulantes*
dc.subject.decsreproducibilidad de resultados*
dc.subject.decsestudios multicéntricos como asunto*
dc.subject.decshumanos*
dc.subject.decsembolia pulmonar*
dc.subject.decsguías de práctica clínica como asunto*
dc.subject.decsensayos clínicos controlados aleatorizados como asunto*
dc.subject.decsecografía*
dc.subject.decstomografía computarizada multidetector*
dc.subject.keywordCHUACes
dc.typefidesArtículo Originales
dc.typesophosArtículo Originales
dc.volume.number42es


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Atribución 4.0 Internacional
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