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High Serum Cyclophilin C Levels as a Risk Factor Marker for Coronary Artery Disease
dc.contributor.author | Alfonso, A. | |
dc.contributor.author | Bayon Lorenzo, Jeremias | |
dc.contributor.author | Gegunde, S. | |
dc.contributor.author | Alonso, E. | |
dc.contributor.author | Alvariño, R. | |
dc.contributor.author | Santas Alvarez, Melisa | |
dc.contributor.author | Testa Fernández, Ana | |
dc.contributor.author | Ríos Vázquez, Ramón | |
dc.contributor.author | González Juanatey, Carlos | |
dc.contributor.author | Botana | |
dc.contributor.author | LM. | |
dc.date.accessioned | 2022-02-02T08:17:54Z | |
dc.date.available | 2022-02-02T08:17:54Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 2045-2322 | |
dc.identifier.other | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646393/pdf/41598_2019_Article_46988.pdf | es |
dc.identifier.uri | http://hdl.handle.net/20.500.11940/16081 | |
dc.description.abstract | Cyclophilins (Cyps) are ubiquitous proteins that belong to the immunophilins family consistently associated with inflammatory and cardiovascular diseases. While levels of CypA have been extensively studied, less data are available for other Cyps. The purpose of this case-control study was to determine the relationship of Cyps (A, B, C and D) with coronary artery disease (CAD) and eight inflammation markers. Serum levels of Cyps, interleukins and metalloproteinases were measured in serum collected from 84 subjects. Participants were divided into two sub-groups based on CAD diagnosis: 40 CAD patients and 44 control volunteers. Serum levels of CypA, CypB and CypC, IL-1beta and IL-6 were significantly higher in CAD patients. Bivariate correlation analysis revealed a significant positive correlation between Cyps and several blood and biochemical parameters. When the ability of Cyps levels for CAD diagnosis was evaluated, higher sensitivity and selectivity values were obtained with CypC (c-statistic 0.891, p < 0.001) indicating that it is a good marker of CAD disease, while less conclusive results were obtained with CypA (c-statistic 0.748, p < 0.001) and CypB (c-statistic 0.655, p < 0.014). In addition, significant correlations of traditional CAD risk factors and CypC were observed. In summary, high levels of CypC are a risk factor for CAD and therefore it can be proposed as a new biomarker for this disease. | en |
dc.language.iso | eng | es |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.mesh | Risk Factors | * |
dc.subject.mesh | Cyclophilin A | * |
dc.subject.mesh | Cyclophilins | * |
dc.subject.mesh | Adult | * |
dc.subject.mesh | Middle Aged | * |
dc.subject.mesh | Humans | * |
dc.subject.mesh | Coronary Artery Disease | * |
dc.subject.mesh | Case-Control Studies | * |
dc.subject.mesh | Aged | * |
dc.title | High Serum Cyclophilin C Levels as a Risk Factor Marker for Coronary Artery Disease | en |
dc.type | Artigo | es |
dc.identifier.doi | 10.1038/s41598-019-46988-x | |
dc.identifier.pmid | 31332225 | |
dc.identifier.sophos | 34997 | |
dc.issue.number | 1 | es |
dc.journal.title | Scientific Reports | es |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Lugo, Cervo e Monforte de lemos - Complexo Hospitalario Universitario Lucus Augusti::Cardioloxía | es |
dc.page.initial | 10576.0 | es |
dc.rights.accessRights | openAccess | es |
dc.subject.decs | ciclofilina A | * |
dc.subject.decs | estudios de casos y controles | * |
dc.subject.decs | anciano | * |
dc.subject.decs | ciclofilinas | * |
dc.subject.decs | factores de riesgo | * |
dc.subject.decs | mediana edad | * |
dc.subject.decs | humanos | * |
dc.subject.decs | enfermedad arterial coronaria | * |
dc.subject.decs | adulto | * |
dc.subject.keyword | HULA | es |
dc.typefides | Artículo Original | es |
dc.typesophos | Artículo Original | es |
dc.volume.number | 9 | es |