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dc.contributor.authorAlfonso, A.
dc.contributor.authorBayon Lorenzo, Jeremias 
dc.contributor.authorGegunde, S.
dc.contributor.authorAlonso, E.
dc.contributor.authorAlvariño, R.
dc.contributor.authorSantas Alvarez, Melisa 
dc.contributor.authorTesta Fernández, Ana
dc.contributor.authorRíos Vázquez, Ramón 
dc.contributor.authorGonzález Juanatey, Carlos 
dc.contributor.authorBotana
dc.contributor.authorLM.
dc.date.accessioned2022-02-02T08:17:54Z
dc.date.available2022-02-02T08:17:54Z
dc.date.issued2019
dc.identifier.issn2045-2322
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646393/pdf/41598_2019_Article_46988.pdfes
dc.identifier.urihttp://hdl.handle.net/20.500.11940/16081
dc.description.abstractCyclophilins (Cyps) are ubiquitous proteins that belong to the immunophilins family consistently associated with inflammatory and cardiovascular diseases. While levels of CypA have been extensively studied, less data are available for other Cyps. The purpose of this case-control study was to determine the relationship of Cyps (A, B, C and D) with coronary artery disease (CAD) and eight inflammation markers. Serum levels of Cyps, interleukins and metalloproteinases were measured in serum collected from 84 subjects. Participants were divided into two sub-groups based on CAD diagnosis: 40 CAD patients and 44 control volunteers. Serum levels of CypA, CypB and CypC, IL-1beta and IL-6 were significantly higher in CAD patients. Bivariate correlation analysis revealed a significant positive correlation between Cyps and several blood and biochemical parameters. When the ability of Cyps levels for CAD diagnosis was evaluated, higher sensitivity and selectivity values were obtained with CypC (c-statistic 0.891, p < 0.001) indicating that it is a good marker of CAD disease, while less conclusive results were obtained with CypA (c-statistic 0.748, p < 0.001) and CypB (c-statistic 0.655, p < 0.014). In addition, significant correlations of traditional CAD risk factors and CypC were observed. In summary, high levels of CypC are a risk factor for CAD and therefore it can be proposed as a new biomarker for this disease.en
dc.language.isoenges
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.meshRisk Factors*
dc.subject.meshCyclophilin A*
dc.subject.meshCyclophilins*
dc.subject.meshAdult*
dc.subject.meshMiddle Aged*
dc.subject.meshHumans*
dc.subject.meshCoronary Artery Disease*
dc.subject.meshCase-Control Studies*
dc.subject.meshAged*
dc.titleHigh Serum Cyclophilin C Levels as a Risk Factor Marker for Coronary Artery Diseaseen
dc.typeArtigoes
dc.identifier.doi10.1038/s41598-019-46988-x
dc.identifier.pmid31332225
dc.identifier.sophos34997
dc.issue.number1es
dc.journal.titleScientific Reportses
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Lugo, Cervo e Monforte de lemos - Complexo Hospitalario Universitario Lucus Augusti::Cardioloxíaes
dc.page.initial10576.0es
dc.rights.accessRightsopenAccesses
dc.subject.decsciclofilina A*
dc.subject.decsestudios de casos y controles*
dc.subject.decsanciano*
dc.subject.decsciclofilinas*
dc.subject.decsfactores de riesgo*
dc.subject.decsmediana edad*
dc.subject.decshumanos*
dc.subject.decsenfermedad arterial coronaria*
dc.subject.decsadulto*
dc.subject.keywordHULAes
dc.typefidesArtículo Originales
dc.typesophosArtículo Originales
dc.volume.number9es


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Atribución 4.0 Internacional
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