Regulation of Epithelial-Mesenchymal Plasticity by the E3 Ubiquitin-Ligases in Cancer
dc.contributor.author | Rodríguez Alonso, Andrea | |
dc.contributor.author | Casas Pais, Alba | |
dc.contributor.author | Roca Lema, Daniel | |
dc.contributor.author | Graña Suárez, Begoña | |
dc.contributor.author | Romay Cousido, Gabriela | |
dc.contributor.author | Figueroa Conde-Valvís, Angélica | |
dc.date.accessioned | 2022-03-04T07:46:08Z | |
dc.date.available | 2022-03-04T07:46:08Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 2072-6694 | |
dc.identifier.other | https://www.ncbi.nlm.nih.gov/pubmed/33114139 | es |
dc.identifier.uri | http://hdl.handle.net/20.500.11940/16154 | |
dc.description.abstract | The epithelial-mesenchymal plasticity (EMP) is a process by which epithelial cells acquire the ability to dynamically switch between epithelial and mesenchymal phenotypic cellular states. Epithelial cell plasticity in the context of an epithelial-to-mesenchymal transition (EMT) confers increased cell motility, invasiveness and the ability to disseminate to distant sites and form metastasis. The modulation of molecularly defined targets involved in this process has become an attractive therapeutic strategy against cancer. Protein degradation carried out by ubiquitination has gained attention as it can selectively degrade proteins of interest. In the ubiquitination reaction, the E3 ubiquitin-ligases are responsible for the specific binding of ubiquitin to a small subset of target proteins, and are considered promising anticancer drug targets. In this review, we summarize the role of the E3 ubiquitin-ligases that control targeted protein degradation in cancer-EMT, and we highlight the potential use of the E3 ubiquitin-ligases as drug targets for the development of small-molecule drugs against cancer. | en |
dc.language.iso | en | es |
dc.rights | Atribución 4.0 Internacional | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.title | Regulation of Epithelial-Mesenchymal Plasticity by the E3 Ubiquitin-Ligases in Cancer | en |
dc.type | Journal Article | es |
dc.authorsophos | Rodríguez-Alonso, Andrea;Casas-Pais, Alba;Roca-Lema, Daniel;Graña, Begoña;Romay, Gabriela;Figueroa, Angélica | |
dc.identifier.doi | 10.3390/cancers12113093 | |
dc.identifier.pmid | 33114139 | |
dc.identifier.sophos | 35561 | |
dc.issue.number | 11 | es |
dc.journal.title | Cancers (Basel) | es |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de A Coruña - Complexo Hospitalario Universitario de A Coruña::Oncoloxía médica | |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Biomédica da Coruña (INIBIC) | |
dc.relation.publisherversion | https://mdpi-res.com/d://attachment/cancers/cancers-12-03093/article://deploy/cancers-12-03093.pdf | es |
dc.rights.accessRights | openAccess | |
dc.subject.keyword | CHUAC | es |
dc.subject.keyword | INIBIC | |
dc.typefides | Artículo de Revisión | es |
dc.typesophos | Artículo de Revisión | es |
dc.volume.number | 12 | es |