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dc.contributor.authorAvila Alvarez, Alejandro 
dc.contributor.authorUrisarri Ruiz de Cortázar, Adela
dc.contributor.authorFuentes Carballal, Jesús
dc.contributor.authorMandía Rodríguez, Natalia 
dc.contributor.authorSUCASAS ALONSO, ANDREA 
dc.contributor.authorCouce Pico, María Luz 
dc.date.accessioned2022-03-04T07:46:36Z
dc.date.available2022-03-04T07:46:36Z
dc.date.issued2020
dc.identifier.issn2072-6643
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/33321828es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/16163
dc.description.abstractDespite the importance of early recognition of metabolic bone disease (MBD) of prematurity, there is still significant variability in screening practices across institutions. We conducted an observational study of infants born at </=32 weeks of gestation with a birth weight of </=1500 g (n = 218) to identify clinical factors associated with biochemical indicators of MBD. Bone mineral status was assessed by measuring alkaline phosphatase and phosphate levels between weeks 3 and 5 of life. Two comparisons were performed after classifying infants as either MBD (cases) or non-MBD (controls), and as either high or low risk for MBD, as determined based on the results of MBD screening. In total, 27 infants (12.3%) were classified as cases and 96 (44%) as high-risk. Compared with controls, MBD infants had a significantly lower gestational age and birth weight, and a longer duration of parenteral nutrition and hospital stay. Respiratory outcomes were significantly poorer in high- versus low-risk infants. Multivariate logistic regression showed that birth weight was the only independent risk factor for MBD (odds ratio [OR]/100 g, 0.811; confidence interval [CI95%], 0.656-0.992; p = 0.045) and that birth weight (OR/100 g, 0.853; CI95%, 0.731-0.991; p = 0.039) and red blood cell transfusion (OR, 2.661; CI95%, 1.308-5.467; p = 0.007) were independent risk factors for high risk of MBD. Our findings provide evidence of risk factors for MBD that could help clinicians to individualize perinatal management. The association of red blood cell transfusion with MBD is a novel finding that may be related to iron overload and that merits further study.es
dc.language.isoenes
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.meshRisk Factors *
dc.subject.meshOdds Ratio *
dc.subject.meshGestational Age *
dc.subject.meshLength of Stay *
dc.subject.meshLogistic Models *
dc.subject.meshParenteral Nutrition *
dc.subject.meshBirth Weight *
dc.subject.meshNeonatal Screening *
dc.subject.meshPhosphates *
dc.subject.meshRisk Assessment *
dc.subject.meshAlkaline Phosphatase *
dc.subject.meshErythrocyte Transfusion *
dc.subject.meshBone Diseases *
dc.subject.meshProspective Studies *
dc.subject.meshRetrospective Studies *
dc.subject.meshInfant *
dc.titleMetabolic Bone Disease of Prematurity: Risk Factors and Associated Short-Term Outcomesen
dc.typeJournal Articlees
dc.authorsophosAvila-Alvarez, Alejandro;Urisarri, Adela;Fuentes-Carballal, Jesús;Mandiá, Natalia;Sucasas-Alonso, Andrea;Couce, María L
dc.identifier.doi10.3390/nu12123786
dc.identifier.pmid33321828
dc.identifier.sophos35611
dc.issue.number12es
dc.journal.titleNutrientses
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de A Coruña - Complexo Hospitalario Universitario de A Coruña::Pediatría
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Biomédica da Coruña (INIBIC)
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Neonatoloxía
dc.relation.publisherversionhttps://mdpi-res.com/d://attachment/nutrients/nutrients-12-03786/article://deploy/nutrients-12-03786-v3.pdfes
dc.rights.accessRightsopenAccess
dc.subject.decsduración de estancia hospitalaria *
dc.subject.decscociente de probabilidades relativas *
dc.subject.decscribado neonatal *
dc.subject.decsfactores de riesgo *
dc.subject.decsestudios prospectivos *
dc.subject.decsestudios retrospectivos*
dc.subject.decspeso al nacer *
dc.subject.decstransfusión de eritrocitos *
dc.subject.decsenfermedades óseas *
dc.subject.decsmodelos logísticos *
dc.subject.decsnutrición parenteral*
dc.subject.decsedad gestacional *
dc.subject.decsfosfatasa alcalina *
dc.subject.decsevaluación de riesgos *
dc.subject.decshumanos *
dc.subject.decslactante *
dc.subject.decsfosfatos *
dc.subject.keywordCHUACes
dc.subject.keywordCHUAC
dc.subject.keywordINIBIC
dc.subject.keywordIDIS
dc.subject.keywordCHUS
dc.typefidesArtículo Originales
dc.typesophosArtículo Originales
dc.volume.number12es


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