Presence of bacterial DNA in thrombotic material of patients with myocardial infarction
Piñón Esteban, Pablo; Nuñez Fernandez, Lucia; Moure González, Raquel; Marron Liñares, Grecia; Flores Ríos, xacobe; Aldama López, Guillermo; Salgado Fernández, Jorge; Calviño Santos, Ramón; REBOLLAL LEAL, FERNANDO; Pan Lizcano, Ricardo Francisco; Vázquez González, Nicolás; Bou Arévalo, Germán; Tomás Carmona, María del Mar; Hermida Prieto, Manuel; Vázquez Rodríguez, José Manuel
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Identificadores
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Fecha de publicación
2020Título de revista
Scientific Reports
Tipo de contenido
Journal Article
DeCS
enfermedades periodontales | pulpitis | ADN | mediana edad | humanos | trombosis | reacción en cadena de la polimerasa en tiempo real | cirugía coronaria percutáneaMeSH
Percutaneous Coronary Intervention | Pulpitis | Middle Aged | Humans | Periodontal Diseases | Thrombosis | Real-Time Polymerase Chain Reaction | DNAResumen
Infectious agents have been suggested to be involved in etiopathogenesis of Acute Coronary Syndrome (ACS). However, the relationship between bacterial infection and acute myocardial infarction (AMI) has not yet been completely clarified. The objective of this study is to detect bacterial DNA in thrombotic material of patients with ACS with ST-segment elevation (STEMI) treated with Primary Percutaneous Coronary Intervention (PPCI). We studied 109 consecutive patients with STEMI, who underwent thrombus aspiration and arterial peripheral blood sampling. Testing for bacterial DNA was performed by probe-based real-time Polymerase Chain Reaction (PCR). 12 probes and primers were used for the detection of Aggregatibacter actinomycetemcomitans, Chlamydia pneumoniae, viridans group streptococci, Porphyromonas gingivalis, Fusobacterium nucleatum, Tannarella forsythia, Treponema denticola, Helycobacter pylori, Mycoplasma pneumoniae, Staphylococus aureus, Prevotella intermedia and Streptococcus mutans. Thus, DNA of four species of bacteria was detected in 10 of the 109 patients studied. The most frequent species was viridans group streptococci (6 patients, 5.5%), followed by Staphylococus aureus (2 patients, 1.8%). Moreover, a patient had DNA of Porphyromonas gingivalis (0.9%); and another patient had DNA of Prevotella intermedia (0.9%). Bacterial DNA was not detected in peripheral blood of any of our patients. In conclusion, DNA of four species of endodontic and periodontal bacteria was detected in thrombotic material of 10 STEMI patients. Bacterial DNA was not detected in the peripheral blood of patients with bacterial DNA in their thrombotic material. Bacteria could be latently present in plaques and might play a role in plaque instability and thrombus formation leading to ACS.
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