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dc.contributor.authorSobrino Moreiras, Tomas 
dc.contributor.authorRodríguez Yáñez, Manuel 
dc.contributor.authorCampos Pérez, Francisco 
dc.contributor.authorIglesias Rey, Ramón
dc.contributor.authorMillán, Mónica
dc.contributor.authorde la Ossa, Natalia Pérez
dc.contributor.authorDávalos, Antonio
dc.contributor.authorDelgado-Mederos, Raquel
dc.contributor.authorMartínez-Domeño, Alejandro
dc.contributor.authorMartí-Fábregas, Joan
dc.contributor.authorCastellanos Rodrigo, María del Mar
dc.contributor.authorSerena, Joaquín
dc.contributor.authorLago, Aida
dc.contributor.authorDíez-Tejedor, Exuperio
dc.contributor.authorCastillo Sánchez, José 
dc.date.accessioned2022-03-08T08:48:38Z
dc.date.available2022-03-08T08:48:38Z
dc.date.issued2020
dc.identifier.issn1868-4483
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/31768951es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/16183
dc.description.abstractThe main objective of this research work was to study the association of serum levels of growth factors (GF) and SDF-1alpha with the functional outcome and reduction of lesion volume in ischemic stroke patients. In this multicenter study, 552 patients with non-lacunar stroke (male, 62.1%; mean age, 68.2 +/- 11.4) were included within 24 h from symptom onset. The main outcome variable was good functional outcome (modified Rankin Scale [mRS] </= 2) at 12 months. Secondary outcome variable was infarct volume (in mL) after 6 +/- 3 months. Serum levels of VEGF, Ang-1, G-CSF, BDNF, and SDF-1alpha were measured by ELISA at admission, 7 +/- 1 days, at 3 +/- 1 months, and 12 +/- 3 months. Except for BDNF, all GF and SDF-1alpha serum levels showed a peak value at day 7 and remained elevated during the first 3 months (all p < 0.01). High serum levels at day 7 of VEGF (OR, 19.3), Ang-1 (OR, 14.7), G-CSF (OR, 9.6), and SDF-1alpha (OR, 28.5) were independently associated with good outcome at 12 months (all p < 0.0001). On the other hand, serum levels of VEGF (B, - 21.4), G-CSF (B, - 14.0), Ang-1 (B, - 13.3), and SDF-1alpha (B, - 44.6) measured at day 7 were independently associated with lesion volume at 6 months (p < 0.01). In summary, high serum levels of VEGF, Ang-1, G-CSF, and SDF-1alpha at day 7 and 3 months after ischemic stroke are associated with good functional outcome and smaller residual lesion at 1 year of follow-up.en
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.meshMiddle Aged*
dc.subject.meshHumans*
dc.subject.meshProspective Studies*
dc.subject.meshIntercellular Signaling Peptides and Proteins*
dc.subject.meshAged*
dc.subject.meshChemokine CXCL12*
dc.subject.meshPrognosis*
dc.titleAssociation of High Serum Levels of Growth Factors with Good Outcome in Ischemic Stroke: a Multicenter Studyen
dc.typeJournal Articlees
dc.authorsophosSobrino, Tomás;Rodríguez-Yáñez, Manuel;Campos, Francisco;Iglesias-Rey, Ramón;Millán, Mónica;de la Ossa, Natalia Pérez;Dávalos, Antonio;Delgado-Mederos, Raquel;Martínez-Domeño, Alejandro;Martí-Fábregas, Joan;Castellanos, Mar;Serena, Joaquín;Lago, Aida;Díez-Tejedor, Exuperio;Castillo, José
dc.identifier.doi10.1007/s12975-019-00747-2
dc.identifier.pmid31768951
dc.identifier.sophos35729
dc.issue.number4es
dc.journal.titleTRANSLATIONAL STROKE RESEARCHes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de A Coruña - Complexo Hospitalario Universitario de A Coruña::Neuroloxíaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Neuroloxíaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)es
dc.relation.publisherversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340658/pdf/12975://2019://Article://747.pdfes
dc.rights.accessRightsopenAccess
dc.subject.decspronóstico *
dc.subject.decsanciano *
dc.subject.decsquimiocina CXCL12 *
dc.subject.decsestudios prospectivos *
dc.subject.decsmediana edad *
dc.subject.decshumanos *
dc.subject.decspéptidos y proteínas de señalización intercelular *
dc.subject.keywordCHUACes
dc.subject.keywordCHUSes
dc.subject.keywordIDISes
dc.typefidesArtículo Originales
dc.typesophosArtículo Originales
dc.volume.number11es


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Atribución 4.0 Internacional
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