dc.contributor.author | Sobrino Moreiras, Tomas | |
dc.contributor.author | Rodríguez Yáñez, Manuel | |
dc.contributor.author | Campos Pérez, Francisco | |
dc.contributor.author | Iglesias Rey, Ramón | |
dc.contributor.author | Millán, Mónica | |
dc.contributor.author | de la Ossa, Natalia Pérez | |
dc.contributor.author | Dávalos, Antonio | |
dc.contributor.author | Delgado-Mederos, Raquel | |
dc.contributor.author | Martínez-Domeño, Alejandro | |
dc.contributor.author | Martí-Fábregas, Joan | |
dc.contributor.author | Castellanos Rodrigo, María del Mar | |
dc.contributor.author | Serena, Joaquín | |
dc.contributor.author | Lago, Aida | |
dc.contributor.author | Díez-Tejedor, Exuperio | |
dc.contributor.author | Castillo Sánchez, José | |
dc.date.accessioned | 2022-03-08T08:48:38Z | |
dc.date.available | 2022-03-08T08:48:38Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 1868-4483 | |
dc.identifier.other | https://www.ncbi.nlm.nih.gov/pubmed/31768951 | es |
dc.identifier.uri | http://hdl.handle.net/20.500.11940/16183 | |
dc.description.abstract | The main objective of this research work was to study the association of serum levels of growth factors (GF) and SDF-1alpha with the functional outcome and reduction of lesion volume in ischemic stroke patients. In this multicenter study, 552 patients with non-lacunar stroke (male, 62.1%; mean age, 68.2 +/- 11.4) were included within 24 h from symptom onset. The main outcome variable was good functional outcome (modified Rankin Scale [mRS] </= 2) at 12 months. Secondary outcome variable was infarct volume (in mL) after 6 +/- 3 months. Serum levels of VEGF, Ang-1, G-CSF, BDNF, and SDF-1alpha were measured by ELISA at admission, 7 +/- 1 days, at 3 +/- 1 months, and 12 +/- 3 months. Except for BDNF, all GF and SDF-1alpha serum levels showed a peak value at day 7 and remained elevated during the first 3 months (all p < 0.01). High serum levels at day 7 of VEGF (OR, 19.3), Ang-1 (OR, 14.7), G-CSF (OR, 9.6), and SDF-1alpha (OR, 28.5) were independently associated with good outcome at 12 months (all p < 0.0001). On the other hand, serum levels of VEGF (B, - 21.4), G-CSF (B, - 14.0), Ang-1 (B, - 13.3), and SDF-1alpha (B, - 44.6) measured at day 7 were independently associated with lesion volume at 6 months (p < 0.01). In summary, high serum levels of VEGF, Ang-1, G-CSF, and SDF-1alpha at day 7 and 3 months after ischemic stroke are associated with good functional outcome and smaller residual lesion at 1 year of follow-up. | en |
dc.rights | Atribución 4.0 Internacional | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject.mesh | Middle Aged | * |
dc.subject.mesh | Humans | * |
dc.subject.mesh | Prospective Studies | * |
dc.subject.mesh | Intercellular Signaling Peptides and Proteins | * |
dc.subject.mesh | Aged | * |
dc.subject.mesh | Chemokine CXCL12 | * |
dc.subject.mesh | Prognosis | * |
dc.title | Association of High Serum Levels of Growth Factors with Good Outcome in Ischemic Stroke: a Multicenter Study | en |
dc.type | Journal Article | es |
dc.authorsophos | Sobrino, Tomás;Rodríguez-Yáñez, Manuel;Campos, Francisco;Iglesias-Rey, Ramón;Millán, Mónica;de la Ossa, Natalia Pérez;Dávalos, Antonio;Delgado-Mederos, Raquel;Martínez-Domeño, Alejandro;Martí-Fábregas, Joan;Castellanos, Mar;Serena, Joaquín;Lago, Aida;Díez-Tejedor, Exuperio;Castillo, José | |
dc.identifier.doi | 10.1007/s12975-019-00747-2 | |
dc.identifier.pmid | 31768951 | |
dc.identifier.sophos | 35729 | |
dc.issue.number | 4 | es |
dc.journal.title | TRANSLATIONAL STROKE RESEARCH | es |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de A Coruña - Complexo Hospitalario Universitario de A Coruña::Neuroloxía | es |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Neuroloxía | es |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS) | es |
dc.relation.publisherversion | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340658/pdf/12975://2019://Article://747.pdf | es |
dc.rights.accessRights | openAccess | |
dc.subject.decs | pronóstico | * |
dc.subject.decs | anciano | * |
dc.subject.decs | quimiocina CXCL12 | * |
dc.subject.decs | estudios prospectivos | * |
dc.subject.decs | mediana edad | * |
dc.subject.decs | humanos | * |
dc.subject.decs | péptidos y proteínas de señalización intercelular | * |
dc.subject.keyword | CHUAC | es |
dc.subject.keyword | CHUS | es |
dc.subject.keyword | IDIS | es |
dc.typefides | Artículo Original | es |
dc.typesophos | Artículo Original | es |
dc.volume.number | 11 | es |