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dc.contributor.authorVarela Rodriguez, Bárbara María
dc.contributor.authorJuiz Valiña, Paula
dc.contributor.authorVarela, Luis
dc.contributor.authorOuteiriño Blanco, Elena 
dc.contributor.authorBravo López, Susana Belén
dc.contributor.authorGarcía Brao, Maria Jesús
dc.contributor.authorMena Del Río, Enrique 
dc.contributor.authorNoguera Aguilar, José Francisco
dc.contributor.authorVALERO GASALLA, JAVIER LUIS 
dc.contributor.authorCORDIDO CARBALLIDO, FERNANDO 
dc.contributor.authorSangiao Alvarellos, Susana
dc.date.accessioned2022-03-08T08:49:28Z
dc.date.available2022-03-08T08:49:28Z
dc.date.issued2020
dc.identifier.issn2077-0383
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/31941045es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/16194
dc.description.abstractBariatric surgery (BS) is the most effective treatment for obesity and has a positive impact on cardiometabolic risk and in the remission of type 2 diabetes. Following BS, the majority of fat mass is lost from the subcutaneous adipose tissue depot (SAT). However, the changes in this depot and functions and as well as its relative contribution to the beneficial effects of this surgery are still controversial. With the aim of studying altered proteins and molecular pathways in abdominal SAT (aSAT) after body weight normalization induced by BS, we carried out a proteomic approach sequential window acquisition of all theoretical mass spectra (SWATH-MS) analysis. These results were complemented by Western blot, electron microscopy and RT-qPCR. With all of the working tools mentioned, we confirmed that after BS, up-regulated proteins were associated with metabolism, the citric acid cycle and respiratory electron transport, triglyceride catabolism and metabolism, formation of ATP, pyruvate metabolism, glycolysis/gluconeogenesis and thermogenesis among others. In contrast, proteins with decreased values are part of the biological pathways related to the immune system. We also confirmed that obesity caused a significant decrease in mitochondrial density and coverage, which was corrected by BS. Together, these findings reveal specific molecular mechanisms, genes and proteins that improve adipose tissue function after BS characterized by lower inflammation, increased glucose uptake, higher insulin sensitivity, higher de novo lipogenesis, increased mitochondrial function and decreased adipocyte size.en
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.meshProteome *
dc.subject.meshMitochondria *
dc.subject.meshImmune System *
dc.subject.meshBariatric Surgery *
dc.subject.meshLipogenesis *
dc.subject.meshMetabolism *
dc.titleBeneficial Effects of Bariatric Surgery-Induced by Weight Loss on the Proteome of Abdominal Subcutaneous Adipose Tissueen
dc.typeJournal Articlees
dc.authorsophosVarela-Rodríguez, Bárbara María;Juiz-Valiña, Paula;Varela, Luis;Outeiriño-Blanco, Elena;Bravo, Susana Belén;García-Brao, María Jesús;Mena, Enrique;Noguera, José Francisco;Valero-Gasalla, Javier;Cordido, Fernando;Sangiao-Alvarellos, Susana
dc.identifier.doi10.3390/jcm9010213
dc.identifier.pmid31941045
dc.identifier.sophos35784
dc.issue.number1es
dc.journal.titleJournal of Clinical Medicinees
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de A Coruña - Complexo Hospitalario Universitario de A Coruña::Dixestivoes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de A Coruña - Complexo Hospitalario Universitario de A Coruña::Endocrinoloxíaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de A Coruña – Hospital Virxe da Xunqueira::Cirurxía plásticaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Biomédica da Coruña (INIBIC)es
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)es
dc.relation.publisherversionhttps://mdpi-res.com/d://attachment/jcm/jcm-09-00213/article://deploy/jcm-09-00213.pdfes
dc.rights.accessRightsopenAccess
dc.subject.decsmitocondrias *
dc.subject.decssistema inmunológico *
dc.subject.decsmetabolismo *
dc.subject.decslipogénesis *
dc.subject.decsproteoma *
dc.subject.decscirugía bariátrica *
dc.subject.keywordCHUACes
dc.subject.keywordHP Virxe Xunqueiraes
dc.subject.keywordINIBICes
dc.subject.keywordIDISes
dc.typefidesArtículo Originales
dc.typesophosArtículo Originales
dc.volume.number9es


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Atribución 4.0 Internacional
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