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dc.contributor.authorJuiz Valiña, Paula
dc.contributor.authorCordido Carro, María
dc.contributor.authorOuteiriño Blanco, Elena 
dc.contributor.authorPertega Diaz, Sonia 
dc.contributor.authorVarela Rodriguez, Bárbara María
dc.contributor.authorGarcía Brao, Maria Jesús
dc.contributor.authorMena Del Río, Enrique 
dc.contributor.authorPena-Bello, Lara
dc.contributor.authorSangiao Alvarellos, Susana
dc.contributor.authorCORDIDO CARBALLIDO, FERNANDO 
dc.date.accessioned2022-03-08T08:49:47Z
dc.date.available2022-03-08T08:49:47Z
dc.date.issued2020
dc.identifier.issn2077-0383
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/32012985es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/16202
dc.description.abstractEndocrine abnormalities are common in obesity, including altered thyroid function. The altered thyroid function of obesity may be due to a mild acquired resistance to the thyroid hormone. The aim of this study was to investigate the effect of weight loss after bariatric surgery (BS) on resistance to thyroid hormones in patients with extreme obesity compared with a control group. We performed an observational study evaluating patients with extreme obesity who underwent BS. We included 106 patients (83 women) and 38 controls (24 women). The primary endpoint was the thyrotroph thyroxine resistance index (TT4RI) and thyroid stimulating hormone (TSH) index (TSHRI). The parameters were studied before and after surgery. TSHRI and TT4RI were higher in the obese patients than in the control group. TT4RI and TSHI decreased significantly over time after surgery, with this decrease being associated with the excessive body mass index (BMI) loss and C-reactive protein (CRP). In extreme obesity, BS promotes a significant decrease in the increased TT4RI and TSHI. This decrease of TT4RI and TSHI is progressive over time after BS and significantly associated with excess BMI lost and CRP. Extreme obesity is characterized by a mild reversible central resistance to thyroid hormones.en
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.meshBariatric Surgery *
dc.subject.meshObesity *
dc.titleCentral Resistance to Thyroid Hormones in Morbidly Obese Subjects Is Reversed after Bariatric Surgery-Induced Weight Lossen
dc.typeJournal Articlees
dc.authorsophosJuiz-Valiña, Paula;Cordido, María;Outeiriño-Blanco, Elena;Pértega, Sonia;Varela-Rodríguez, Bárbara María;García-Brao, María Jesús;Mena, Enrique;Pena-Bello, Lara;Sangiao-Alvarellos, Susana;Cordido, Fernando
dc.identifier.doi10.3390/jcm9020359
dc.identifier.pmid32012985
dc.identifier.sophos35838
dc.issue.number2es
dc.journal.titleJournal of Clinical Medicinees
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de A Coruña - Complexo Hospitalario Universitario de A Coruña::Cirurxía Xeral e dixestivaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de A Coruña - Complexo Hospitalario Universitario de A Coruña::Endocrinoloxíaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Biomédica da Coruña (INIBIC)es
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de A Coruña - Complexo Hospitalario Universitario de A Coruña::Epidemioloxíaes
dc.relation.publisherversionhttps://mdpi-res.com/d://attachment/jcm/jcm-09-00359/article://deploy/jcm-09-00359-v2.pdfes
dc.rights.accessRightsopenAccess
dc.subject.decsobesidad *
dc.subject.decscirugía bariátrica *
dc.subject.keywordCHUACes
dc.subject.keywordINIBICes
dc.typefidesArtículo Originales
dc.typesophosArtículo Originales
dc.volume.number9es


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Atribución 4.0 Internacional
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