Randomized clinical trial to determine the effectiveness of CO-oximetry and anti-smoking brief advice in a cohort of kidney transplant patients who smoke
Identificadores
Identificadores
URI: http://hdl.handle.net/20.500.11940/16220
PMID: 33162795
DOI: 10.7150/ijms.49401
ISSN: 1449-1907
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Fecha de publicación
2020Título de revista
International Journal of Medical Sciences
Tipo de contenido
Journal Article
DeCS
resultado del tratamiento | trasplante de riñón | ensayo clínico controlado | educación de pacientes como asunto | autoinforme | estudios de seguimiento | mediana edad | adulto | rechazo del injerto | motivación | cotinina | cese del hábito de fumar | monóxido de carbono | humanos | hábito de fumar | oximetríaMeSH
Middle Aged | Carbon Monoxide | Oximetry | Follow-Up Studies | Patient Education as Topic | Self Report | Graft Rejection | Smoking | Humans | Treatment Outcome | Motivation | Smoking Cessation | Controlled Clinical Trial | Cotinine | Kidney TransplantationResumen
Background: measure the efficacy of exhaled carbon monoxide (CO) measurement plus brief advisory sessions to reduce smoking exposure and smoking behaviour in kidney transplant recipients. Methods: Randomized, controlled, open-label clinical trial at a Spanish hospital.Smoking kidney transplant recipients giving their consent to participate were randomized to control (brief advice, n=63) or intervention group (brief advisory session plus measuring exhaled CO, n=59). Measurements: Sociodemographic characteristics, cardiovascular risk factors, treatment, rejection episodes, infections, self-reported smoking, drug use, level of dependence and motivation to stop smoking (Fagerstrom's and Richmond's test) and stage of change (Prochaska and DiClemente's Stages). Efficacy was assessed at 3, 6, 9 and 12 months as: cotinine test, CO levels in exhaled air, nicotine dependence, motivational stages of change, motivation to stop smoking, pattern of tobacco use and smoking cessation rates. Logistic regression models were computed. Results: At 12 months of follow-up, differences were found in exhaled CO between the intervention and control group(6.1+/-6.8vs.10.2+/-9.7ppm;p=0.028). Carboxyhemoglobin levels were lower in the intervention group as well as the positive cotinine test (1.2+/-1.2%vs.2.0+/-2.4%;p=0.039),(53.4%vs.74.2%). At 12 months, intervention reduces the probability of a positive urine test by 28%. Conclusions: Co-oximetry is a clinically relevant intervention for reduction of tobacco exposure in kidney transplant recipients.