Show simple item record

dc.contributor.authorJuiz Valiña, Paula
dc.contributor.authorPena Bello, María Lara
dc.contributor.authorCordido Carro, María
dc.contributor.authorOuteiriño Blanco, Elena 
dc.contributor.authorPertega Diaz, Sonia 
dc.contributor.authorVarela Rodriguez, Bárbara María
dc.contributor.authorGarcía Brao, Maria Jesús
dc.contributor.authorMena Del Río, Enrique 
dc.contributor.authorSangiao-Alvarellos, Susana
dc.contributor.authorCORDIDO CARBALLIDO, FERNANDO 
dc.date.accessioned2022-03-08T08:51:44Z
dc.date.available2022-03-08T08:51:44Z
dc.date.issued2020
dc.identifier.issn2077-0383
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/32806629es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/16227
dc.description.abstractEndocrine disorders are common in obesity, including altered somatotropic axis. Obesity is characterized by reduced growth hormone (GH) secretion, although the insulin-like growth factor-1 (IGF-1) values are controversial. The aim of this study was to evaluate the effect of weight loss after bariatric surgery in the GH-IGF-1 axis in extreme obesity, in order to investigate IGF-1 values and the mechanism responsible for the alteration of the GH-IGF-1 axis in obesity. We performed an interventional trial in morbidly obese patients who underwent bariatric surgery. We included 116 patients (97 women) and 41 controls (30 women). The primary endpoint was circulating GH and IGF-1 values. Circulating IGF-1 values were lower in the obese patients than in the controls. Circulating GH and IGF-1 values increased significantly over time after surgery. Post-surgery changes in IGF-1 and GH values were significantly negatively correlated with changes in C-reactive protein (CRP) and free T4 values. After adjusting for preoperative body mass index (BMI), free T4 and CRP in a multivariate model, only CRP was independently associated with IGF-1 values in the follow-up. In summary, severe obesity is characterized by a functional hyposomatotropism at central and peripheral level that is progressively reversible with weight loss, and low-grade chronic inflammation could be the principal mediator.en
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleAltered GH-IGF-1 Axis in Severe Obese Subjects is Reversed after Bariatric Surgery-Induced Weight Loss and Related with Low-Grade Chronic Inflammationen
dc.typeJournal Articlees
dc.authorsophosJuiz-Valiña, Paula;Pena-Bello, Lara;Cordido, Maria;Outeiriño-Blanco, Elena;Pértega, Sonia;Varela-Rodriguez, Barbara;Garcia-Brao, Maria Jesus;Mena, Enrique;Sangiao-Alvarellos, Susana;Cordido, Fernando
dc.identifier.doi10.3390/jcm9082614
dc.identifier.pmid32806629
dc.identifier.sophos35974
dc.issue.number8es
dc.journal.titleJournal of Clinical Medicinees
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de A Coruña - Complexo Hospitalario Universitario de A Coruña::Dixestivoes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de A Coruña - Complexo Hospitalario Universitario de A Coruña::Endocrinoloxíaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Biomédica da Coruña (INIBIC)es
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de A Coruña - Complexo Hospitalario Universitario de A Coruña::Epidemioloxíaes
dc.relation.publisherversionhttps://mdpi-res.com/d://attachment/jcm/jcm-09-02614/article://deploy/jcm-09-02614.pdfes
dc.rights.accessRightsopenAccess
dc.subject.keywordCHUACes
dc.subject.keywordINIBICes
dc.typefidesArtículo Originales
dc.typesophosArtículo Originales
dc.volume.number9es


Files in this item

This item appears in the following Collection(s)

Show simple item record

Atribución 4.0 Internacional
Except where otherwise noted, this item's license is described as Atribución 4.0 Internacional