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dc.contributor.authorSangiao-Alvarellos, Susana
dc.contributor.authorTheofilatos, Konstantinos
dc.contributor.authorBarwari, Temo
dc.contributor.authorGutmann, Clemens
dc.contributor.authorTakov, Kaloyan
dc.contributor.authorSingh, Bhawana
dc.contributor.authorJuiz Valiña, Paula
dc.contributor.authorVarela Rodriguez, Bárbara María
dc.contributor.authorOuteiriño Blanco, Elena 
dc.contributor.authorDuregotti, Elisa
dc.contributor.authorZampetaki, Anna
dc.contributor.authorLunger, Lukas
dc.contributor.authorEbenbichler, Christoph
dc.contributor.authorTilg, Herbert
dc.contributor.authorGarcía Brao, Maria Jesús
dc.contributor.authorWilleit, Peter
dc.contributor.authorMena Del Río, Enrique 
dc.contributor.authorKiechl, Stefan
dc.contributor.authorCORDIDO CARBALLIDO, FERNANDO 
dc.contributor.authorMayr, Manuel
dc.date.accessioned2022-03-16T08:36:53Z
dc.date.available2022-03-16T08:36:53Z
dc.date.issued2020
dc.identifier.issn2052-4897
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/33115818es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/16245
dc.description.abstractINTRODUCTION: Bariatric surgery offers the most effective treatment for obesity, ameliorating or even reverting associated metabolic disorders, such as type 2 diabetes. We sought to determine the effects of bariatric surgery on circulating microRNAs (miRNAs) that have been implicated in the metabolic cross talk between the liver and adipose tissue. RESEARCH DESIGN AND METHODS: We measured 30 miRNAs in 155 morbidly obese patients and 47 controls and defined associations between miRNAs and metabolic parameters. Patients were followed up for 12 months after bariatric surgery. Key findings were replicated in a separate cohort of bariatric surgery patients with up to 18 months of follow-up. RESULTS: Higher circulating levels of liver-related miRNAs, such as miR-122, miR-885-5 p or miR-192 were observed in morbidly obese patients. The levels of these miRNAs were positively correlated with body mass index, percentage fat mass, blood glucose levels and liver transaminases. Elevated levels of circulating liver-derived miRNAs were reversed to levels of non-obese controls within 3 months after bariatric surgery. In contrast, putative adipose tissue-derived miRNAs remained unchanged (miR-99b) or increased (miR-221, miR-222) after bariatric surgery, suggesting a minor contribution of white adipose tissue to circulating miRNA levels. Circulating levels of liver-derived miRNAs normalized along with the endocrine and metabolic recovery of bariatric surgery, independent of the fat percentage reduction. CONCLUSIONS: Since liver miRNAs play a crucial role in the regulation of hepatic biochemical processes, future studies are warranted to assess whether they may serve as determinants or mediators of metabolic risk in morbidly obese patients.en
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleMetabolic recovery after weight loss surgery is reflected in serum microRNAsen
dc.typeJournal Articlees
dc.authorsophosSangiao-Alvarellos, Susana;Theofilatos, Konstantinos;Barwari, Temo;Gutmann, Clemens;Takov, Kaloyan;Singh, Bhawana;Juiz-Valiña, Paula;Varela-Rodríguez, Bárbara María;Outeiriño-Blanco, Elena;Duregotti, Elisa;Zampetaki, Anna;Lunger, Lukas;Ebenbichler, Christoph;Tilg, Herbert;García-Brao, María Jesús;Willeit, Peter;Mena, Enrique;Kiechl, Stefan;Cordido, Fernando;Mayr, Manuel
dc.identifier.doi10.1136/bmjdrc-2020-001441
dc.identifier.pmid33115818
dc.identifier.sophos36050
dc.issue.number2es
dc.journal.titleBMJ open diabetes research & carees
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de A Coruña - Complexo Hospitalario Universitario de A Coruña::Cirurxía Xeral e dixestivaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de A Coruña - Complexo Hospitalario Universitario de A Coruña::Endocrinoloxíaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Biomédica da Coruña (INIBIC)es
dc.rights.accessRightsopenAccess
dc.subject.keywordCHUACes
dc.subject.keywordINIBICes
dc.typefidesArtículo Originales
dc.typesophosArtículo Originales
dc.volume.number8es


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Atribución 4.0 Internacional
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