Expression and Functionality Study of 9 Toll-Like Receptors in 33 Drug-Naïve Non-Affective First Episode Psychosis Individuals: A 3-Month Study
Identificadores
Identificadores
URI: http://hdl.handle.net/20.500.11940/16282
PMID: 32854231
DOI: 10.3390/ijms21176106
ISSN: 1661-6596
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Visualización o descarga de ficheros
Fecha de publicación
2020Título de revista
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Tipo de contenido
Journal Article
DeCS
receptor 8 similar a toll | estudios de casos y controles | trastornos psicóticos | antipsicóticos | estudios prospectivos | adulto joven | linfocitos T | humanos | leucocitos | adulto | receptor 5 similar a toll | linfocitos BMeSH
Psychotic Disorders | Adult | Humans | Young Adult | T-Lymphocytes | Toll-Like Receptor 5 | Leukocytes | B-Lymphocytes | Prospective Studies | Toll-Like Receptor 8 | Case-Control Studies | Antipsychotic AgentsResumen
Toll-like receptors (TLRs) are a pivotal component of the innate immune system that seem to have a role in the pathogenesis of psychosis. The purpose of this work was to compare the expression and functionality of 9 TLRs in three peripheral blood mononuclear cells (PBMCs) (monocytes, B cells, and T cells) between 33 drug-naive first-episode psychosis (FEP) individuals and 26 healthy volunteers, at baseline and after 3-month of antipsychotic treatment. The expression of TLRs 1-9 were assessed by flow cytometry. For the assessment of the TLR functionality, cells collected in sodium heparin tubes were polyclonally stimulated for 18 h, with different agonists for human TLR1-9. The results of our study highlight the role that TLR5 and TLR8 might play in the pathophysiology of psychosis. We found a lower expression of these receptors in FEP individuals, regarding healthy volunteers at baseline and after 3-month of treatment on the three PBMCs subsets. Most TLRs showed a lower functionality (especially reduced intracellular levels of TNF-alpha) in patients than in healthy volunteers. These results, together with previous evidence, suggest that individuals with psychosis might show a pattern of TLR expression that differs from that of healthy volunteers, which could vary according to the intensity of immune/inflammatory response.