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dc.contributor.authorMoriczi, Melinda
dc.contributor.authorPujol-Muncunill, Gemma
dc.contributor.authorMartín-Masot, Rafael
dc.contributor.authorJiménez Treviño, Santiago
dc.contributor.authorSegarra Cantón, Oscar
dc.contributor.authorOchoa Sangrador, Carlos
dc.contributor.authorPeña Quintana, Luis
dc.contributor.authorGonzález Santana, Daniel
dc.contributor.authorRodríguez Martínez, Alejandro
dc.contributor.authorRosell Camps, Antonio
dc.contributor.authorArmas, Honorio
dc.contributor.authorBarrio, Josefa
dc.contributor.authorGonzález de Caldas, Rafael
dc.contributor.authorRodríguez Salas, Mónica
dc.contributor.authorBalmaseda Serrano, Elena
dc.contributor.authorDonat Aliaga, Ester
dc.contributor.authorBodas Pinedo, Andrés
dc.contributor.authorVaquero Sosa, Esther
dc.contributor.authorVecino López, Raquel
dc.contributor.authorSolar Boga, Alfonso 
dc.contributor.authorMoreno Alvarez, Ana 
dc.contributor.authorSánchez Sánchez, César
dc.contributor.authorTolín Hernani, Mar
dc.contributor.authorGutiérrez Junquera, Carolina
dc.contributor.authorMartinon Torres, Nazareth 
dc.contributor.authorLeis Trabazo, María Rosaura 
dc.contributor.authorEizaguirre, Francisco Javier
dc.contributor.authorGarcía Peris, Mónica
dc.contributor.authorMedina Benítez, Enrique
dc.contributor.authorFERNANDEZ CAAMAÑO, BEATRIZ 
dc.contributor.authorVegas Álvarez, Ana María
dc.contributor.authorCrespo Valderrábano, Laura
dc.contributor.authorAlonso Vicente, Carmen
dc.contributor.authorRubio Santiago, Javier
dc.contributor.authorGalera-Martínez, Rafael
dc.contributor.authorGarcía-Romero, Ruth
dc.contributor.authorRos Arnal, Ignacio
dc.contributor.authorFernández Cebrián, Santiago Andrés 
dc.contributor.authorLorenzo Garrido, Helena
dc.contributor.authorViada Bris, Javier Francisco
dc.contributor.authorVelasco Rodríguez-Belvis, Marta
dc.contributor.authorBartolomé Porro, Juan Manuel
dc.contributor.authorBlanco Rodríguez, Miriam
dc.contributor.authorBarros García, Patricia
dc.contributor.authorBotija, Gonzalo
dc.contributor.authorChicano Marín, Francisco José
dc.contributor.authorLa Orden Izquierdo, Enrique
dc.contributor.authorCrehuá-Gaudiza, Elena
dc.contributor.authorNavas-López, Víctor Manuel
dc.contributor.authorMartín-de-Carpi, Javier
dc.date.accessioned2022-03-17T08:18:12Z
dc.date.available2022-03-17T08:18:12Z
dc.date.issued2020
dc.identifier.issn2072-6643
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/32272604es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/16291
dc.description.abstractExclusive enteral nutrition (EEN) has been shown to be more effective than corticosteroids in achieving mucosal healing in children with Crohn s disease (CD) without the adverse effects of these drugs. The aims of this study were to determine the efficacy of EEN in terms of inducing clinical remission in children newly diagnosed with CD, to describe the predictive factors of response to EEN and the need for treatment with biological agents during the first 12 months of the disease. We conducted an observational retrospective multicentre study that included paediatric patients newly diagnosed with CD between 2014-2016 who underwent EEN. Two hundred and twenty-two patients (140 males) from 35 paediatric centres were included, with a mean age at diagnosis of 11.6 +/- 2.5 years. The median EEN duration was 8 weeks (IQR 6.6-8.5), and 184 of the patients (83%) achieved clinical remission (weighted paediatric Crohn's Disease activity index [wPCDAI] < 12.5). Faecal calprotectin (FC) levels (mug/g) decreased significantly after EEN (830 [IQR 500-1800] to 256 [IQR 120-585] p < 0.0001). Patients with wPCDAI </= 57.5, FC < 500 mug/g, CRP >15 mg/L and ileal involvement tended to respond better to EEN. EEN administered for 6-8 weeks is effective for inducing clinical remission. Due to the high response rate in our series, EEN should be used as the first-line therapy in luminal paediatric Crohn's disease regardless of the location of disease and disease activity.es
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.meshRemission Induction*
dc.subject.meshHumans*
dc.subject.meshCrohn Disease*
dc.subject.meshAdolescent*
dc.subject.meshRetrospective Studies*
dc.titlePredictors of Response to Exclusive Enteral Nutrition in Newly Diagnosed Crohn´s Disease in Children: PRESENCE Study from SEGHNPen
dc.typeJournal Articlees
dc.authorsophosMoriczi, Melinda;Pujol-Muncunill, Gemma;Martín-Masot, Rafael;Jiménez Treviño, Santiago;Segarra Cantón, Oscar;Ochoa Sangrador, Carlos;Peña Quintana, Luis;González Santana, Daniel;Rodríguez Martínez, Alejandro;Rosell Camps, Antonio;Armas, Honorio;Barrio, Josefa;González de Caldas, Rafael;Rodríguez Salas, Mónica;Balmaseda Serrano, Elena;Donat Aliaga, Ester;Bodas Pinedo, Andrés;Vaquero Sosa, Esther;Vecino López, Raquel;Solar Boga, Alfonso;Moreno Álvarez, Ana;Sánchez Sánchez, César;Tolín Hernani, Mar;Gutiérrez Junquera, Carolina;Martinón Torres, Nazareth;Leis Trabazo, María Rosaura;Eizaguirre, Francisco Javier;García Peris, Mónica;Medina Benítez, Enrique;Fernández Caamaño, Beatriz;Vegas Álvarez, Ana María;Crespo Valderrábano, Laura;Alonso Vicente, Carmen;Rubio Santiago, Javier;Galera-Martínez, Rafael;García-Romero, Ruth;Ros Arnal, Ignacio;Fernández Cebrián, Santiago;Lorenzo Garrido, Helena;Viada Bris, Javier Francisco;Velasco Rodríguez-Belvis, Marta;Bartolomé Porro, Juan Manuel;Blanco Rodríguez, Miriam;Barros García, Patricia;Botija, Gonzalo;Chicano Marín, Francisco José;La Orden Izquierdo, Enrique;Crehuá-Gaudiza, Elena;Navas-López, Víctor Manuel;Martín-de-Carpi, Javier
dc.identifier.doi10.3390/nu12041012
dc.identifier.pmid32272604
dc.identifier.sophos36255
dc.issue.number4es
dc.journal.titleNutrientses
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de A Coruña - Complexo Hospitalario Universitario de A Coruña::Pediatríaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Pediatríaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Ourense, Verín e O Barco de Valdeorras - Complexo Hospitalario Universitario de Ourense::Pediatríaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Vigo - Complexo Hospitalario Universitario de Vigo::Pediatríaes
dc.rights.accessRightsopenAccess
dc.subject.decsinducción de remisión*
dc.subject.decsestudios retrospectivos*
dc.subject.decsenfermedad de Crohn*
dc.subject.decshumanos*
dc.subject.decsadolescente*
dc.subject.keywordCHUACes
dc.subject.keywordCHUSes
dc.subject.keywordCHUOes
dc.subject.keywordCHUVIes
dc.typefidesArtículo Originales
dc.typesophosArtículo Originales
dc.volume.number12es


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Atribución 4.0 Internacional
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