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dc.contributor.authorRúa-Figueroa, Iñigo
dc.contributor.authorLópez-Longo, Francisco J
dc.contributor.authorDel Campo, Víctor
dc.contributor.authorGalindo-Izquierdo, María
dc.contributor.authorUriarte, Esther
dc.contributor.authorTorre-Cisneros, Julián
dc.contributor.authorVela, Paloma
dc.contributor.authorTomero, Eva
dc.contributor.authorNarváez, Javier
dc.contributor.authorOlivé, Alejandro
dc.contributor.authorFreire Gonzalez, Mercedes 
dc.contributor.authorSalgado Pérez, Eva 
dc.contributor.authorAndreu, José Luis
dc.contributor.authorMartínez-Taboada, Víctor
dc.contributor.authorCalvo-Alén, Jaime
dc.contributor.authorHernández-Cruz, Blanca
dc.contributor.authorRaya, Enrique
dc.contributor.authorQuevedo Vila, Victor 
dc.contributor.authorExpósito Pérez, Lorena
dc.contributor.authorFernández-Nebro, Antonio
dc.contributor.authorIbañez, Mónica
dc.contributor.authorPascual-Valls, Èlia
dc.contributor.authorRúa-Figueroa, David
dc.contributor.authorNaranjo, Antonio
dc.contributor.authorPego Reigosa, José María 
dc.date.accessioned2022-03-17T08:18:37Z
dc.date.available2022-03-17T08:18:37Z
dc.date.issued2020
dc.identifier.issn0315-162X
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/30988123es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/16296
dc.description.abstractOBJECTIVE: To describe the incidence of bacteremia in a large multicentric cohort of patients with systemic lupus erythematosus (SLE) and their clinical characteristics and to identify risk factors. METHODS: All bacteremic episodes from the Spanish RELESSER registry were included. Clinical and laboratory characteristics concerning bacteremia and SLE status, as well as comorbidities at the time of infection, were retrospectively collected. A comparison with sex- and age-matched SLE controls without bacteremia was made. A logistic regression was conducted. RESULTS: The study included 114 episodes of bacteremia in 83 patients. The incidence rate was 2.7/1000 patient-years. At the time of bacteremia, the median age was 40.5 (range: 8-90) years, and 88.6% of patients were female. The Safety of Estrogens in Lupus Erythematosus National Assessment-Systemic Lupus Erythematosus Disease Activity Index was 4 [interquartile range (IQR) 8]; 41% had an SLE flare (66% severe); Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index was 3 (IQR 4). A comorbidity was recorded in 64% of cases. At the time of bacteremia, 88.6% received corticosteroids (68.6% > 10 mg/day) and 57% immunosuppressors. Gram-negative bacilli, most frequently Escherichia coli (29.8%), caused 52.6% of the episodes. The bacteremia-related mortality was 14% and bacteremia was recurrent in 27.2% of cases. A dose-response relationship was found between corticosteroids and bacteremia risk. In the multivariate analysis, these factors were associated with bacteremia: elevated creatinine (OR 1.31, 95% CI 1.01-1.70; p = 0.045), diabetes (OR 6.01, 95% CI 2.26-15.95; p < 0.001), cancer (OR 5.32, 95% CI 2.23-12.70; p < 0.001), immunosuppressors (OR 6.35, 95% CI 3.42-11.77; p < 0.001), and damage (OR 1.65, 95% CI 1.31-2.09; p < 0.001). CONCLUSION: Bacteremia occurred mostly in patients with active SLE and was frequently associated with severe flares and corticosteroid use. Recurrence and mortality were high. Immunosuppressors, comorbidities, and disease-related damage were associated with bacteremia.en
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.meshRisk Factors*
dc.subject.meshAdult*
dc.subject.meshBacteremia*
dc.subject.meshMiddle Aged*
dc.subject.meshLogistic Models*
dc.subject.meshAdolescent*
dc.subject.meshAdrenal Cortex Hormones*
dc.subject.meshSeverity of Illness Index*
dc.subject.meshIncidence*
dc.subject.meshImmunosuppressive Agents*
dc.subject.meshHumans*
dc.subject.meshTreatment Outcome*
dc.subject.meshYoung Adult*
dc.subject.meshAged*
dc.subject.meshRetrospective Studies*
dc.titleBacteremia in Systemic Lupus Erythematosus in Patients from a Spanish Registry: Risk Factors, Clinical and Microbiological Characteristics, and Outcomesen
dc.typeJournal Articlees
dc.authorsophosRúa-Figueroa, Iñigo;López-Longo, Francisco J;Del Campo, Víctor;Galindo-Izquierdo, María;Uriarte, Esther;Torre-Cisneros, Julián;Vela, Paloma;Tomero, Eva;Narváez, Javier;Olivé, Alejandro;Freire, Mercedes;Salgado, Eva;Andreu, José Luis;Martínez-Taboada, Víctor;Calvo-Alén, Jaime;Hernández-Cruz, Blanca;Raya, Enrique;Quevedo, Víctor;Expósito Pérez, Lorena;Fernández-Nebro, Antonio;Ibañez, Mónica;Pascual-Valls, Èlia;Rúa-Figueroa, David;Naranjo, Antonio;Pego-Reigosa, José M
dc.identifier.doi10.3899/jrheum.180882
dc.identifier.pmid30988123
dc.identifier.sophos36297
dc.issue.number2es
dc.journal.titleJOURNAL OF RHEUMATOLOGYes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de A Coruña - Complexo Hospitalario Universitario de A Coruña::Reumatoloxíaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Ourense, Verín e O Barco de Valdeorras - Complexo Hospitalario Universitario de Ourense::Reumatoloxíaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Vigo - Complexo Hospitalario Universitario de Vigo::Reumatoloxíaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Lugo, Cervo e Monforte de lemos - Hospital Comarcal de Monforte::Reumatoloxíaes
dc.relation.publisherversionhttps://www.jrheum.org/content/jrheum/47/2/234.full.pdfes
dc.rights.accessRightsopenAccess
dc.subject.decsresultado del tratamiento*
dc.subject.decsincidencia*
dc.subject.decsfactores de riesgo*
dc.subject.decsestudios retrospectivos*
dc.subject.decsmediana edad*
dc.subject.decshormonas de la corteza suprarrenal*
dc.subject.decsadulto*
dc.subject.decsíndice de gravedad de la enfermedad*
dc.subject.decsmodelos logísticos*
dc.subject.decsanciano*
dc.subject.decsinmunosupresores*
dc.subject.decsadulto joven*
dc.subject.decshumanos*
dc.subject.decsbacteriemia*
dc.subject.decsadolescente*
dc.subject.keywordCHUACes
dc.subject.keywordCHUOes
dc.subject.keywordCHUVIes
dc.subject.keywordHP Monfortees
dc.typefidesArtículo Originales
dc.typesophosArtículo Originales
dc.volume.number47es


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Atribución 4.0 Internacional
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