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dc.contributor.authorAparicio, Jorge
dc.contributor.authorEsposito, Francis
dc.contributor.authorSerrano, Sara
dc.contributor.authorFalco, Esther
dc.contributor.authorEscudero, Pilar
dc.contributor.authorRuiz-Casado, Ana
dc.contributor.authorManzano, Hermini
dc.contributor.authorFernández Montes, Ana 
dc.date.accessioned2022-03-23T08:55:01Z
dc.date.available2022-03-23T08:55:01Z
dc.date.issued2020
dc.identifier.issn2077-0383
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/33265959es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/16370
dc.description.abstractColorectal cancer (CRC) is a commonly diagnosed malignancy. The prognosis of patients with unresectable, metastatic colorectal cancer (mCRC) is dismal and medical treatment is mainly palliative in nature. Although chemotherapy remains the backbone of treatment, the landscape is changing with the understanding of its heterogeneity and molecular biology. First-line therapy relies on a combination of chemotherapy and targeted therapies, according to clinical patient characteristics and tumor molecular profile. Here we review current evidence from randomized clinical trials for using chemotherapy doublets or triplets, and for the addition of bevacizumab or anti-epidermal growth factor receptor (EGFR) agents. Novel therapies developed for small, selected populations are also discussed.en
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleMetastatic Colorectal Cancer. First Line Therapy for Unresectable Disease.en
dc.typeJournal Articlees
dc.authorsophosAparicio, Jorge;Esposito, Francis;Serrano, Sara;Falco, Esther;Escudero, Pilar;Ruiz-Casado, Ana;Manzano, Hermini;Fernandez-Montes, Ana
dc.identifier.doi10.3390/jcm9123889
dc.identifier.pmid33265959
dc.identifier.sophos36730
dc.issue.number12es
dc.journal.titleJournal of Clinical Medicinees
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Ourense, Verín e O Barco de Valdeorras - Complexo Hospitalario Universitario de Ourense::Oncoloxía médicaes
dc.rights.accessRightsopenAccess
dc.subject.keywordCHUOes
dc.typefidesArtículo de Revisiónes
dc.typesophosArtículo de Revisiónes
dc.volume.number9es


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Atribución 4.0 Internacional
Except where otherwise noted, this item's license is described as Atribución 4.0 Internacional