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dc.contributor.authorSeoane-Viaño, Iria
dc.contributor.authorGómez Lado, Noemí
dc.contributor.authorLazare Iglesias, Hector 
dc.contributor.authorGarcía Otero, Xurxo
dc.contributor.authorAntúnez López, José Ramón 
dc.contributor.authorRuibal Morell, Alvaro 
dc.contributor.authorVarela Correa, Juan Jesús 
dc.contributor.authorAguiar Fernández, Pablo
dc.contributor.authorBasit, Abdul W
dc.contributor.authorOtero-Espinar, Francisco J
dc.contributor.authorGonzález Barcia, Miguel 
dc.contributor.authorGoyanes, Alvaro
dc.contributor.authorLuzardo-Álvarez, Asteria
dc.contributor.authorFernández Ferreiro, Anxo
dc.date.accessioned2022-03-23T08:56:17Z
dc.date.available2022-03-23T08:56:17Z
dc.date.issued2020
dc.identifier.issn2227-9059
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/33276641es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/16389
dc.description.abstractThe aim of this study was to fabricate novel self-supporting tacrolimus suppositories using semisolid extrusion 3-dimensional printing (3DP) and to investigate their efficacy in an experimental model of inflammatory bowel disease. Blends of Gelucire 44/14 and coconut oil were employed as lipid excipients to obtain suppository formulations with self-emulsifying properties, which were then tested in a TNBS (2,4,6-trinitrobenzenesulfonic acid) induced rat colitis model. Disease activity was monitored using PET/CT medical imaging; maximum standardized uptake values (SUVmax), a measure of tissue radiotracer accumulation rate, together with body weight changes and histological assessments, were used as inflammatory indices to monitor treatment efficacy. Following tacrolimus treatment, a significant reduction in SUVmax was observed on days 7 and 10 in the rat colon sections compared to non-treated animals. Histological analysis using Nancy index confirmed disease remission. Moreover, statistical analysis showed a positive correlation (R(2) = 71.48%) between SUVmax values and weight changes over time. Overall, this study demonstrates the effectiveness of 3D printed tacrolimus suppositories to ameliorate colitis and highlights the utility of non-invasive PET/CT imaging to evaluate new therapies in the preclinical area.en
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.title3D Printed Tacrolimus Rectal Formulations Ameliorate Colitis in an Experimental Animal Model of Inflammatory Bowel Disease.en
dc.typeJournal Articlees
dc.authorsophosSeoane-Viaño, Iria;Gómez-Lado, Noemí;Lázare-Iglesias, Héctor;García-Otero, Xurxo;Antúnez-López, José Ramón;Ruibal, Álvaro;Varela-Correa, Juan Jesús;Aguiar, Pablo;Basit, Abdul W;Otero-Espinar, Francisco J;González-Barcia, Miguel;Goyanes, Alvaro;Luzardo-Álvarez, Asteria;Fernández-Ferreiro, Anxo
dc.identifier.doi10.3390/biomedicines8120563
dc.identifier.pmid33276641
dc.identifier.sophos36924
dc.issue.number12es
dc.journal.titleBIOMEDICINESes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Anatomía Patolóxicaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Farmaciaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Medicina nucleares
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Ourense, Verín e O Barco de Valdeorras - Complexo Hospitalario Universitario de Ourense::Farmaciaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)es
dc.rights.accessRightsopenAccess
dc.subject.keywordCHUSes
dc.subject.keywordCHUOes
dc.subject.keywordIDISes
dc.typefidesArtículo Originales
dc.typesophosArtículo Originales
dc.volume.number8es


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