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dc.contributor.authorLorenzo Lopez, Laura
dc.contributor.authorBlanco Fandiño, Julia
dc.contributor.authorCibeira González, Nuria
dc.contributor.authorBujan Mera, Ana
dc.contributor.authorLOPEZ LOPEZ, ROCIO 
dc.contributor.authorMaseda Rodriguez, Ana Belen
dc.contributor.authorMILLAN CALENTI, JOSE CARLOS
dc.date.accessioned2022-03-23T08:56:41Z
dc.date.available2022-03-23T08:56:41Z
dc.date.issued2020
dc.identifier.issn2296-858X
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/33240913es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/16396
dc.description.abstractPhysical frailty is closely associated with cognitive impairment. We aim to investigate the neuropsychological profiles of prefrail and non-frail dementia-free community-dwelling older adults using a comprehensive neuropsychological evaluation, and to examine the association between specific frailty criteria and clinical and neuropsychological scores. Participants completed a comprehensive standardized neuropsychological evaluation (covering cognitive domains such as memory, executive functions, language and attention), and frailty assessment. Frailty was assessed according to biological criteria: unintentional weight loss, exhaustion, low physical activity, slowness, and weakness. The sample comprised 60 dementia-free community-dwelling adults, aged 65 years or older (range 65-89 years; 60.0% women). Forty-two participants were classified as robust (no frailty criteria present), and 18 as prefrail (1 or 2 frailty criteria present). We explored neurocognitive differences between the groups and examined the association between specific criteria of frailty phenotype and clinical and neuropsychological outcomes with bivariate tests and multivariate models. Prefrail participants showed poorer cognitive performance than non-frail participants in both memory and non-memory cognitive domains. However, delayed episodic memory was the only cognitive subdomain that remained significant after controlling for age, gender, and educational level. Gait speed was significantly associated with general cognitive performance, immediate memory, and processing speed, while grip strength was associated with visual episodic memory and visuoconstructive abilities. Both gait speed and grip strength were negatively associated with depressive scores. Our results suggest that prefrailty is associated with cognitive dysfunction. The fact that specific cognitive domains may be susceptible to subclinical states of physical frailty may have important clinical implications. Indeed, early detection of specific cognitive dysfunctions may allow opportunities for reversibility.en
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleClinical and Neuropsychological Correlates of Prefrailty Syndromeen
dc.typeJournal Articlees
dc.authorsophosLorenzo-Lopez, L Blanco-Fandino, J Cibeira, N Bujan, A Lopez-Lopez, R Maseda, A Millan-Calenti, JC
dc.identifier.doi10.3389/fmed.2020.609359
dc.identifier.pmid33240913
dc.identifier.sophos38436
dc.journal.titleFRONTIERS IN MEDICINE (LAUSANNE)es
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Biomédica da Coruña (INIBIC)es
dc.rights.accessRightsopenAccess
dc.subject.keywordINIBICes
dc.typefidesArtículo Originales
dc.typesophosArtículo Originales
dc.volume.number7.es


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