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dc.contributor.authorAlonso Alconada, Lorena
dc.contributor.authorDe La Fuente González, Alexandre
dc.contributor.authorSantacana, M.
dc.contributor.authorFerreirós López, Alba
dc.contributor.authorLópez López, Rafael 
dc.contributor.authorMatias-Guiu, X.
dc.contributor.authorAbal Posada, Miguel 
dc.date.accessioned2022-04-12T11:37:43Z
dc.date.available2022-04-12T11:37:43Z
dc.date.issued2020
dc.identifier.issn1754-8403
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/32764154es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/16458
dc.description.abstractMetastasis is facilitated by the formation of pre-metastatic niches through the remodelling of the extracellular matrix (ECM) promoted by haematopoietic and stromal cells. The impact of these primed sites is pronounced for intraperitoneal metastases, where the cavity-exposed ECM supports the attachment of the disseminating tumour cells. Likewise, implantation of biomaterial scaffolds influences metastatic progression systemically through a foreign body reaction (FBR). In this study, we integrated the concept of creating an artificial niche to capture tumour cells actively disseminating in the peritoneal cavity with a therapeutic strategy modulating the interactions of metastatic cells with the ECM. The aim was to transform a disseminated disease into a focal disease. For this, we designed and developed a 'biomimetic' ECM composed of a nonresorbable three-dimensional scaffold with collagen coating and characterized the FBR to the implanted biomaterial. We also analysed the safety of the implanted devices and their ability to capture tumour cells in different murine preclinical models of advanced ovarian cancer. Implantation of the biomimetic devices resulted in an initial inflammatory reaction that transformed progressively into a fibrous connective tissue response. The adhesive capabilities of the scaffold were improved with the ancillary effect of the FBR and showed clinical utility in terms of the efficacy of capture of tumour cells, disease focalization and survival benefit. These results demonstrated the performance and safety of this 'biomimetic' ECM in preclinical models of advanced ovarian cancer. Translated into the clinical setting, this new therapeutic strategy represents the possibility for control of peritoneal carcinomatosis upon primary ovarian debulking surgery and to expand the percentage of patients who are candidates for second rescue surgeries at the time of relapse.en
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.meshForeign-Body Migration*
dc.subject.meshXenograft Model Antitumor Assays*
dc.subject.meshPeritoneal Neoplasms*
dc.subject.meshCell Line*
dc.subject.meshBiomimetics*
dc.subject.meshHumans*
dc.subject.meshTime Factors*
dc.subject.meshMice*
dc.subject.meshExtracellular Matrix*
dc.subject.meshAnimals*
dc.subject.meshTumor Microenvironment*
dc.subject.meshOvarian Neoplasms*
dc.titleBiomimetic device and foreign body reaction cooperate for efficient tumour cell capture in murine advanced ovarian canceren
dc.typeJournal Articlees
dc.authorsophosAlonso-Alconada, L.;de la Fuente, A.;Santacana, M.;Ferreiros, A.;Lopez-Lopez, R.;Matias-Guiu, X.;Abal, M.
dc.identifier.doi10.1242/dmm.043653
dc.identifier.pmid32764154
dc.identifier.sophos38896
dc.issue.number6es
dc.journal.titleDisease Models & Mechanismses
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Oncoloxía médicaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)es
dc.rights.accessRightsopenAccess
dc.subject.decsbiomimética *
dc.subject.decsanimales *
dc.subject.decsneoplasias ováricas *
dc.subject.decsmatriz extracelular *
dc.subject.decslínea celular *
dc.subject.decsmicroambiente tumoral *
dc.subject.decsneoplasias peritoneales *
dc.subject.decshumanos *
dc.subject.decsfactores de tiempo *
dc.subject.decsensayos antitumorales por modelo de xenoinjerto *
dc.subject.decsratones *
dc.subject.decsmigración de cuerpo extraño *
dc.subject.keywordCHUSes
dc.subject.keywordIDISes
dc.typefidesArtículo Originales
dc.typesophosArtículo Originales
dc.volume.number13es


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Atribución 4.0 Internacional
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