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dc.contributor.authorAntón Aparicio, Luis Miguel
dc.contributor.authorAbella Cajigal, Vanesa
dc.contributor.authorValladares Ayerbes, Manuel 
dc.contributor.authorFigueroa Conde-Valvís, Angélica
dc.date.accessioned2017-06-07T07:00:48Z
dc.date.available2017-06-07T07:00:48Z
dc.date.issued2013
dc.identifier.issn1420-682X
dc.identifier.urihttp://hdl.handle.net/20.500.11940/1649
dc.description.abstractEpithelial-to-mesenchymal transition (EMT), one of the crucial steps for carcinoma cells to acquire invasive capacity, results from the disruption of cell-cell contacts and the acquisition of a motile mesenchymal phenotype. Although the transcriptional events controlling EMT have been extensively studied, in recent years, several posttranscriptional mechanisms have emerged as critical in the regulation of EMT during tumor progression. In this review, we highlight the regulation of posttranscriptional events in EMT by RNA-binding proteins (RBPs). RBPs are responsible for controlling pre-mRNA splicing, capping, and polyadenylation, as well as mRNA export, turnover, localization, and translation. We discuss the most relevant aspects of RBPs controlling the metabolism of EMT-related mRNAs, and describe the implication of novel posttranscriptional mechanisms regulating EMT in response to different signaling pathways. Novel insight into posttranscriptional regulation of EMT by RBPs is uncovering new therapeutic targets in cancer invasion and metastasis.
dc.language.isoeng
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.meshAlternative Splicing 
dc.subject.meshEpithelial-Mesenchymal Transition
dc.subject.meshNeoplasms 
dc.subject.meshRNA Processing, Post-Transcriptional
dc.subject.meshRNA, Messenger 
dc.subject.meshARN Mensajero
dc.titlePosttranscriptional regulation by RNA-binding proteins during epithelial-to-mesenchymal transition
dc.typeArtigoes
dc.authorsophosAparicio, L. A.
dc.authorsophosAbella, V.
dc.authorsophosValladares, M.
dc.authorsophosFigueroa, A.
dc.identifier.doi10.1007/s00018-013-1379-0
dc.identifier.isi327076100004
dc.identifier.sophos11869
dc.issue.number23
dc.journal.titleCELLULAR AND MOLECULAR LIFE SCIENCES
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de A Coruña - Complexo Hospitalario Universitario A Coruña::Oncoloxía médica
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de A Coruña::INIBIC.- Instituto de Investigación Biomédica
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Biomédica da Coruña (INIBIC)
dc.page.initial4463
dc.page.final4477
dc.rights.accessRightsopenAccess
dc.subject.decsEmpalme Alternativo
dc.subject.decsTransición Epitelial-Mesenquimal
dc.subject.decsNeoplasias 
dc.subject.decsProcesamiento Postranscripcional del ARN
dc.typesophosArtículo Original
dc.volume.number70


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Atribución 4.0 Internacional
Except where otherwise noted, this item's license is described as Atribución 4.0 Internacional