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Levels of the Novel Endogenous Antagonist of Ghrelin Receptor, Liver-Enriched Antimicrobial Peptide-2, in Patients with Rheumatoid Arthritis
dc.contributor.author | Francisco, V. | |
dc.contributor.author | Tovar Carro, Sulay | |
dc.contributor.author | Conde, J. | |
dc.contributor.author | Pino Mínguez, Jesús | |
dc.contributor.author | Mera Varela, Antonio | |
dc.contributor.author | Lago Paz, Francisca | |
dc.contributor.author | González-Gay, M. A. | |
dc.contributor.author | Diéguez González, Carlos | |
dc.contributor.author | Gualillo ., Oreste | |
dc.date.accessioned | 2022-04-26T07:42:07Z | |
dc.date.available | 2022-04-26T07:42:07Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 2072-6643 | |
dc.identifier.other | https://www.ncbi.nlm.nih.gov/pubmed/32268520 | es |
dc.identifier.uri | http://hdl.handle.net/20.500.11940/16502 | |
dc.description.abstract | Rheumatoid arthritis (RA) is a debilitating, chronic, inflammatory, autoimmune disease associated with cachexia. The substitutive therapy of gut hormone ghrelin has been pointed at as a potential countermeasure for the management of metabolic and inflammatory complications in RA. The recent discovery of liver-expressed antimicrobial peptide 2 (LEAP2) as an endogenous inverse agonist/antagonist of the ghrelin receptor makes feasible the development of a more rational pharmacological approach. This work aimed to assess the serum LEAP2 levels, in a cohort of RA patients, in comparison with healthy individuals and determine its correlation with inflammatory parameters. LEAP2 levels were determined by a commercial ELISA kit, plasma C-reactive protein (CRP) levels were evaluated using immunoturbidimetry, and serum levels of inflammatory mediators, namely IL-6, IL-8, IL-1beta, MIP1alpha, MCP1, and LCN2, were measured by XMap multiplex assay. LEAP2 serum levels were significantly increased in RA patients (n = 101) compared with control subjects (n = 26). Furthermore, the LEAP2 levels significantly correlated with CRP and inflammatory cytokines, but not with BMI. These data reveal LEAP2 as a new potential RA biomarker and indicated the pharmacological control of LEAP2 levels as a novel approach for the treatment of diseases with alterations on the ghrelin levels, such as rheumatoid cachexia. | en |
dc.rights | Atribución 4.0 Internacional | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject.mesh | Humans | * |
dc.subject.mesh | Cytokines | * |
dc.subject.mesh | Antimicrobial Cationic Peptides | * |
dc.subject.mesh | C-Reactive Protein | * |
dc.subject.mesh | Blood Proteins | * |
dc.subject.mesh | Arthritis | * |
dc.title | Levels of the Novel Endogenous Antagonist of Ghrelin Receptor, Liver-Enriched Antimicrobial Peptide-2, in Patients with Rheumatoid Arthritis | en |
dc.type | Journal Article | es |
dc.authorsophos | Francisco, V.;Tovar, S.;Conde, J.;Pino, J.;Mera, A.;Lago, F.;González-Gay, M. A.;Dieguez, C.;Gualillo, O. | |
dc.identifier.doi | 10.3390/nu12041006 | |
dc.identifier.pmid | 32268520 | |
dc.identifier.sophos | 39046 | |
dc.issue.number | 4 | es |
dc.journal.title | Nutrients | es |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Reumatoloxía | es |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Traumatoloxía | es |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS) | es |
dc.page.initial | 1006 | es |
dc.page.final | 1006 | es |
dc.rights.accessRights | openAccess | |
dc.subject.decs | proteínas sanguíneas | * |
dc.subject.decs | citocinas | * |
dc.subject.decs | humanos | * |
dc.subject.decs | péptidos catiónicos antimicrobianos | * |
dc.subject.decs | proteína C reactiva | * |
dc.subject.decs | artritis | * |
dc.subject.keyword | CHUS | es |
dc.subject.keyword | IDIS | es |
dc.typefides | Artículo Original | es |
dc.typesophos | Artículo Original | es |
dc.volume.number | 12 | es |