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Psychophysical Olfactory Tests and Detection of COVID-19 in Patients With Sudden Onset Olfactory Dysfunction: A Prospective Study
dc.contributor.author | Lechien, J. R. | |
dc.contributor.author | Cabaraux, P. | |
dc.contributor.author | Chiesa Estomba, Carlos Miguel | |
dc.contributor.author | Khalife, M. | |
dc.contributor.author | Plzak, J. | |
dc.contributor.author | Hans, S. | |
dc.contributor.author | Martiny, D. | |
dc.contributor.author | CALVO HENRIQUEZ, CHRISTIAN EZEQUIEL | |
dc.contributor.author | Barillari, M. R. | |
dc.contributor.author | Hopkins, C. | |
dc.contributor.author | Saussez, S. | |
dc.date.accessioned | 2022-04-26T07:43:19Z | |
dc.date.available | 2022-04-26T07:43:19Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 0145-5613 | |
dc.identifier.other | https://www.ncbi.nlm.nih.gov/pubmed/32469246 | es |
dc.identifier.uri | http://hdl.handle.net/20.500.11940/16526 | |
dc.description.abstract | OBJECTIVE: To investigate the coronavirus disease 2019 (COVID-19) status of patients with initial sudden olfactory anosmia (ISOA) through nasopharyngeal swabs for reverse transcription-polymerase chain reaction (RT-PCR) analysis and to explore their olfactory dysfunctions with psychophysical olfactory evaluation. METHODS: A total of 78 ISOA patients were recruited from April 6, 2020, to April 10, 2020, through a public call of University of Mons (Mons, Belgium). Patients benefited from nasopharyngeal swabs and fulfilled the patient-reported outcome questionnaire. Among them, 46 patients performed psychophysical olfactory evaluation using olfactory identification testing. Based on the duration of the ISOA, 2 groups of patients were compared: patients with olfactory dysfunction duration </=12 days (group 1) and those with duration >12 days (group 2). RESULTS: In group 1, 42 patients (87.5%) had a positive viral load determined by RT-PCR and 6 patients (12.5%) were negative. In group 2, 7 patients (23%) had a positive viral load and 23 patients (77%) were negative. The psychophysical olfactory evaluation reported that anosmia and hyposmia occurred in 24 (52%) and 11 (24%) patients, respectively. Eleven patients were normosmic. The viral load was significantly higher in patients of group 1 compared with those of group 2. CONCLUSIONS: Coronavirus disease 2019 was detected in a high proportion of ISOA patients, especially over the first 12 days of olfactory dysfunction. Anosmia is an important symptom to consider in the detection of COVID-19 infection. | en |
dc.rights | Atribución-NoComercial 4.0 Internacional | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | |
dc.subject.mesh | Clinical Laboratory Techniques | * |
dc.subject.mesh | Pandemics | * |
dc.subject.mesh | Adult | * |
dc.subject.mesh | Physical Stimulation | * |
dc.subject.mesh | Middle Aged | * |
dc.subject.mesh | Humans | * |
dc.subject.mesh | Reverse Transcriptase Polymerase Chain Reaction | * |
dc.subject.mesh | Young Adult | * |
dc.subject.mesh | Dysgeusia | * |
dc.subject.mesh | Coronavirus Infections | * |
dc.subject.mesh | Prospective Studies | * |
dc.subject.mesh | Pneumonia | * |
dc.subject.mesh | Case-Control Studies | * |
dc.subject.mesh | Aged | * |
dc.subject.mesh | Olfaction Disorders | * |
dc.subject.mesh | Nasal Obstruction | * |
dc.title | Psychophysical Olfactory Tests and Detection of COVID-19 in Patients With Sudden Onset Olfactory Dysfunction: A Prospective Study | en |
dc.type | Journal Article | es |
dc.authorsophos | Lechien, J. R.;Cabaraux, P.;Chiesa-Estomba, C. M.;Khalife, M.;Plzak, J.;Hans, S.;Martiny, D.;Calvo-Henriquez, C.;Barillari, M. R.;Hopkins, C.;Saussez, S. | |
dc.identifier.doi | 10.1177/0145561320929169 | |
dc.identifier.pmid | 32469246 | |
dc.identifier.sophos | 39161 | |
dc.issue.number | 9 | es |
dc.journal.title | ENT-EAR NOSE & THROAT JOURNAL | es |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Otorrinolaringoloxía | es |
dc.page.initial | 579 | es |
dc.page.final | 583 - | es |
dc.rights.accessRights | openAccess | |
dc.subject.decs | estudios de casos y controles | * |
dc.subject.decs | estimulación física | * |
dc.subject.decs | estudios prospectivos | * |
dc.subject.decs | técnicas de laboratorio clínico | * |
dc.subject.decs | pandemias | * |
dc.subject.decs | reacción en cadena de la polimerasa por transcriptasa inversa | * |
dc.subject.decs | mediana edad | * |
dc.subject.decs | disgeusia | * |
dc.subject.decs | adulto | * |
dc.subject.decs | obstrucción nasal | * |
dc.subject.decs | anciano | * |
dc.subject.decs | neumonía | * |
dc.subject.decs | adulto joven | * |
dc.subject.decs | humanos | * |
dc.subject.decs | trastornos del olfato | * |
dc.subject.decs | infecciones por Coronavirus | * |
dc.subject.keyword | CHUS | es |
dc.typefides | Artículo Original | es |
dc.typesophos | Artículo Original | es |
dc.volume.number | 99 | es |
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