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dc.contributor.authorBoughanem, H.
dc.contributor.authorMartin-Nunez, G. M.
dc.contributor.authorTorres, E.
dc.contributor.authorArranz-Salas, I.
dc.contributor.authorAlcaide, J.
dc.contributor.authorMorcillo, S.
dc.contributor.authorTinahones, F. J.
dc.contributor.authorCrujeiras Martínez, Ana Belén
dc.contributor.authorMacias-Gonzalez, M.
dc.date.accessioned2022-04-29T10:25:56Z
dc.date.available2022-04-29T10:25:56Z
dc.date.issued2020
dc.identifier.issn2075-4426
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/33187096es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/16599
dc.description.abstractRecent studies suggest that long-interspersed nucleotide element-1 (LINE-1) hypomethylation is commonly found in colorectal cancer (CRC), and is associated with worse prognosis. However, the utility of LINE-1 methylation on the prognosis of CRC is still controversial, and may be due to the fact that some clinical and pathological features may affect LINE-1 methylation. Thus, the aim of this study was to assess the prognostic value of tumor LINE-1 methylation in CRC, through their association with the CRC clinical and pathological characteristics. Survival of sixty-seven CRC patients was evaluated according to the median of tumor LINE-1 methylation, as well as pathological and oncological variables. We also studied the association between LINE-1 methylation and pathological features, and finally, we assessed the overall and disease-free survival of LINE1 methylation, stratified by neoadjuvant treatment and further checked by multivariate Cox regression to assess the statistical interactions. LINE-1 was hypomethylated in the CRC tumor with respect to the tumor adjacent-free area (p < 0.05), without association with any other clinical and oncological features, nor with overall and disease-free survival rates for CRC. Relevantly, in neoadjuvant treatment, LINE-1 methylation was associated with survival rates. Thus, disease-free and overall survival rates of treated CRC patients were worse in the hypomethylated LINE-1 tumors than those with normal LINE-1 methylation (p = 0.004 and 0.0049, respectively). Indeed, LINE-1 was hypermethylated more in the treated patients than in the non-treated patients (p < 0.05). The present study showed that tumor LINE-1 hypomethylation was associated with worse survival rates in only treated patients. Our data suggest an interactive effect of neoadjuvant treatment and tumor LINE-1 methylation, which could be a specific-tissue biomarker to predict survival of the treated patients, and help to personalize treatment in CRC.en
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleImpact of Tumor LINE-1 Methylation Level and Neoadjuvant Treatment and Its Association with Colorectal Cancer Survivalen
dc.typeJournal Articlees
dc.authorsophosBoughanem, H.;Martin-Nunez, G. M.;Torres, E.;Arranz-Salas, I.;Alcaide, J.;Morcillo, S.;Tinahones, F. J.;Crujeiras, A. B.;Macias-Gonzalez, M.
dc.identifier.doi10.3390/jpm10040219
dc.identifier.pmid33187096
dc.identifier.sophos39538
dc.issue.number4es
dc.journal.titleJOURNAL OF PERSONALIZED MEDICINEes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)es
dc.rights.accessRightsopenAccess
dc.subject.keywordIDISes
dc.typefidesArtículo Originales
dc.typesophosArtículo Originales
dc.volume.number10es


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