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dc.contributor.authorGarcía Vence, María
dc.contributor.authorChantada Vázquez, María Pilar
dc.contributor.authorCameselle Teijeiro, Jose Manuel 
dc.contributor.authorBravo López, Susana Belén
dc.contributor.authorNúñez González, Cristina
dc.date.accessioned2022-04-29T10:28:01Z
dc.date.available2022-04-29T10:28:01Z
dc.date.issued2020
dc.identifier.issn2079-4991
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/33260544es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/16632
dc.description.abstractA thyroid nodule is the most common presentation of thyroid cancer; thus, it is extremely important to differentiate benign from malignant nodules. Within malignant lesions, classification of a thyroid tumor is the primary step in the assessment of the prognosis and selection of treatment. Currently, fine-needle aspiration biopsy (FNAB) is the preoperative test most commonly used for the initial thyroid nodule diagnosis. However, due to some limitations of FNAB, different high-throughput "omics" approaches have emerged that could further support diagnosis based on histopathological patterns. In the present work, formalin-fixed paraffin-embedded (FFPE) tissue specimens from normal (non-neoplastic) thyroid (normal controls (NCs)), benign tumors (follicular thyroid adenomas (FTAs)), and some common types of well-differentiated thyroid carcinoma (follicular thyroid carcinomas (FTCs), conventional or classical papillary thyroid carcinomas (CV-PTCs), and the follicular variant of papillary thyroid carcinomas (FV-PTCs)) were analyzed. For the first time, FFPE thyroid samples were deparaffinized using an easy, fast, and non-toxic method. Protein extracts from thyroid tissue samples were analyzed using a nanoparticle-assisted proteomics approach combined with shotgun LC-MS/MS. The differentially regulated proteins found to be specific for the FTA, FTC, CV-PTC, and FV-PTC subtypes were analyzed with the bioinformatic tools STRING and PANTHER showing a profile of proteins implicated in the thyroid cancer metabolic reprogramming, cancer progression, and metastasis. These proteins represent a new source of potential molecular targets related to thyroid tumors.en
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleA Novel Nanoproteomic Approach for the Identification of Molecular Targets Associated with Thyroid Tumorsen
dc.typeJournal Articlees
dc.authorsophosGarcia-Vence, M.;Chantada-Vazquez, M. D.;Cameselle-Teijeiro, J. M.;Bravo, S. B.;Nunez, C.
dc.identifier.doi10.3390/nano10122370
dc.identifier.pmid33260544
dc.identifier.sophos39709
dc.issue.number12es
dc.journal.titleNANOMATERIALS (BASEL)es
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Anatomía Patolóxicaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)es
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Lugo, Cervo e Monforte de lemos - Complexo Hospitalario Universitario Lucus Augusti::Unidade de Investigaciónes
dc.page.initial2370es
dc.rights.accessRightsopenAccess
dc.subject.keywordCHUSes
dc.subject.keywordIDISes
dc.subject.keywordHULAes
dc.typefidesArtículo Originales
dc.typesophosArtículo Originales
dc.volume.number10es


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