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A Novel Nanoproteomic Approach for the Identification of Molecular Targets Associated with Thyroid Tumors
dc.contributor.author | García Vence, María | |
dc.contributor.author | Chantada Vázquez, María Pilar | |
dc.contributor.author | Cameselle Teijeiro, Jose Manuel | |
dc.contributor.author | Bravo López, Susana Belén | |
dc.contributor.author | Núñez González, Cristina | |
dc.date.accessioned | 2022-04-29T10:28:01Z | |
dc.date.available | 2022-04-29T10:28:01Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 2079-4991 | |
dc.identifier.other | https://www.ncbi.nlm.nih.gov/pubmed/33260544 | es |
dc.identifier.uri | http://hdl.handle.net/20.500.11940/16632 | |
dc.description.abstract | A thyroid nodule is the most common presentation of thyroid cancer; thus, it is extremely important to differentiate benign from malignant nodules. Within malignant lesions, classification of a thyroid tumor is the primary step in the assessment of the prognosis and selection of treatment. Currently, fine-needle aspiration biopsy (FNAB) is the preoperative test most commonly used for the initial thyroid nodule diagnosis. However, due to some limitations of FNAB, different high-throughput "omics" approaches have emerged that could further support diagnosis based on histopathological patterns. In the present work, formalin-fixed paraffin-embedded (FFPE) tissue specimens from normal (non-neoplastic) thyroid (normal controls (NCs)), benign tumors (follicular thyroid adenomas (FTAs)), and some common types of well-differentiated thyroid carcinoma (follicular thyroid carcinomas (FTCs), conventional or classical papillary thyroid carcinomas (CV-PTCs), and the follicular variant of papillary thyroid carcinomas (FV-PTCs)) were analyzed. For the first time, FFPE thyroid samples were deparaffinized using an easy, fast, and non-toxic method. Protein extracts from thyroid tissue samples were analyzed using a nanoparticle-assisted proteomics approach combined with shotgun LC-MS/MS. The differentially regulated proteins found to be specific for the FTA, FTC, CV-PTC, and FV-PTC subtypes were analyzed with the bioinformatic tools STRING and PANTHER showing a profile of proteins implicated in the thyroid cancer metabolic reprogramming, cancer progression, and metastasis. These proteins represent a new source of potential molecular targets related to thyroid tumors. | en |
dc.rights | Atribución 4.0 Internacional | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.title | A Novel Nanoproteomic Approach for the Identification of Molecular Targets Associated with Thyroid Tumors | en |
dc.type | Journal Article | es |
dc.authorsophos | Garcia-Vence, M.;Chantada-Vazquez, M. D.;Cameselle-Teijeiro, J. M.;Bravo, S. B.;Nunez, C. | |
dc.identifier.doi | 10.3390/nano10122370 | |
dc.identifier.pmid | 33260544 | |
dc.identifier.sophos | 39709 | |
dc.issue.number | 12 | es |
dc.journal.title | NANOMATERIALS (BASEL) | es |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Anatomía Patolóxica | es |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS) | es |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Lugo, Cervo e Monforte de lemos - Complexo Hospitalario Universitario Lucus Augusti::Unidade de Investigación | es |
dc.page.initial | 2370 | es |
dc.rights.accessRights | openAccess | |
dc.subject.keyword | CHUS | es |
dc.subject.keyword | IDIS | es |
dc.subject.keyword | HULA | es |
dc.typefides | Artículo Original | es |
dc.typesophos | Artículo Original | es |
dc.volume.number | 10 | es |