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Validation of an IGF1 Screening Method for Retinopathy of Pre-maturity
dc.contributor.author | Pérez Muñuzuri, Alejandro | |
dc.contributor.author | López Suárez, Olalla Elena | |
dc.contributor.author | Mandía Rodríguez, Natalia | |
dc.contributor.author | López Sanguos, Carolina | |
dc.contributor.author | Blanco Teijeiro, María Jose | |
dc.contributor.author | Couce Pico, María Luz | |
dc.date.accessioned | 2022-05-05T08:28:16Z | |
dc.date.available | 2022-05-05T08:28:16Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 2296-2360 | |
dc.identifier.other | https://www.ncbi.nlm.nih.gov/pubmed/33381481 | es |
dc.identifier.uri | http://hdl.handle.net/20.500.11940/16680 | |
dc.description.abstract | Retinopathy of pre-maturity (ROP) is a retinal disease that causes arrest of vascularization of the retina and can result in retinal detachment and blindness. Current screening protocols may not be sufficiently accurate to identify all at-risk patients. The aim of this study is to validate a method for improved identification of newborns at risk of ROP. We conducted a prospective clinical trial of pre-term newborns <32 weeks of gestation and/or <1,500 g birth weight during a 6-year period in a tertiary care hospital. We applied our new method based on measurement of insulin-like growth factor 1 (IGF1) levels at 3 weeks of age and the presence of sepsis during the first 3 weeks of life. Our screening protocol allowed exclusion of 121 (79.1%) patients for whom American Academy of Pediatrics (AAP) guidelines recommended screening, had a negative predictive value of 100%, and correctly identified all patients with ROP. Following retrospective assessment of our data based on these findings, we propose further restriction of the current AAP indications for screening to <1,100 g and <28 weeks of gestation in order to improve diagnostic efficacy while ensuring optimal use of restriction of human and material resources. | en |
dc.rights | Atribución 4.0 Internacional | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.title | Validation of an IGF1 Screening Method for Retinopathy of Pre-maturity | en |
dc.type | Journal Article | es |
dc.authorsophos | Perez-Munuzuri, A.;Lopez-Suarez, O.;Mandia-Rodriguez, N.;Lopez-Sanguos, C.;Blanco-Teijeiro, M. J.;Couce, M. L. | |
dc.identifier.doi | 10.3389/fped.2020.615716 | |
dc.identifier.pmid | 33381481 | |
dc.identifier.sophos | 39875 | |
dc.journal.title | FRONTIERS IN PEDIATRICS | es |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Oftalmoloxía | es |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Pediatría | es |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS) | es |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Neonatoloxía | es |
dc.page.initial | 615716 | es |
dc.rights.accessRights | openAccess | |
dc.subject.keyword | CHUS | es |
dc.subject.keyword | IDIS | es |
dc.typefides | Artículo Original | es |
dc.typesophos | Artículo Original | es |
dc.volume.number | 8. | es |