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dc.contributor.authorPérez Muñuzuri, Alejandro 
dc.contributor.authorLópez Suárez, Olalla Elena 
dc.contributor.authorMandía Rodríguez, Natalia 
dc.contributor.authorLópez Sanguos, Carolina
dc.contributor.authorBlanco Teijeiro, María Jose 
dc.contributor.authorCouce Pico, María Luz 
dc.date.accessioned2022-05-05T08:28:16Z
dc.date.available2022-05-05T08:28:16Z
dc.date.issued2020
dc.identifier.issn2296-2360
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/33381481es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/16680
dc.description.abstractRetinopathy of pre-maturity (ROP) is a retinal disease that causes arrest of vascularization of the retina and can result in retinal detachment and blindness. Current screening protocols may not be sufficiently accurate to identify all at-risk patients. The aim of this study is to validate a method for improved identification of newborns at risk of ROP. We conducted a prospective clinical trial of pre-term newborns <32 weeks of gestation and/or <1,500 g birth weight during a 6-year period in a tertiary care hospital. We applied our new method based on measurement of insulin-like growth factor 1 (IGF1) levels at 3 weeks of age and the presence of sepsis during the first 3 weeks of life. Our screening protocol allowed exclusion of 121 (79.1%) patients for whom American Academy of Pediatrics (AAP) guidelines recommended screening, had a negative predictive value of 100%, and correctly identified all patients with ROP. Following retrospective assessment of our data based on these findings, we propose further restriction of the current AAP indications for screening to <1,100 g and <28 weeks of gestation in order to improve diagnostic efficacy while ensuring optimal use of restriction of human and material resources.en
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleValidation of an IGF1 Screening Method for Retinopathy of Pre-maturityen
dc.typeJournal Articlees
dc.authorsophosPerez-Munuzuri, A.;Lopez-Suarez, O.;Mandia-Rodriguez, N.;Lopez-Sanguos, C.;Blanco-Teijeiro, M. J.;Couce, M. L.
dc.identifier.doi10.3389/fped.2020.615716
dc.identifier.pmid33381481
dc.identifier.sophos39875
dc.journal.titleFRONTIERS IN PEDIATRICSes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Oftalmoloxíaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Pediatríaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)es
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Neonatoloxíaes
dc.page.initial615716es
dc.rights.accessRightsopenAccess
dc.subject.keywordCHUSes
dc.subject.keywordIDISes
dc.typefidesArtículo Originales
dc.typesophosArtículo Originales
dc.volume.number8.es


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