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dc.contributor.authorRapado González, Oscar
dc.contributor.authorMartinez-Reglero, C.
dc.contributor.authorSalgado Barreira, Angel 
dc.contributor.authorRodriguez-Fernandez, A.
dc.contributor.authorAguin Losada, Santiago 
dc.contributor.authorLeón Mateos, Luis Ángel 
dc.contributor.authorMuinelo Romay , Laura
dc.contributor.authorLópez López, Rafael 
dc.contributor.authorSuarez-Cunqueiro, Maria Mercedes
dc.date.accessioned2022-05-05T08:28:33Z
dc.date.available2022-05-05T08:28:33Z
dc.date.issued2020
dc.identifier.issn2077-0383
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/32370055es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/16686
dc.description.abstractBACKGROUND: Human papillomavirus (HPV) infection has been recognized as an important risk factor in cancer. The purpose of this systematic review and meta-analysis was to determine the prevalence and effect size of association between salivary HPV DNA and the risk of developing oral and oropharyngeal cancer. METHODS: A systematic literature search of PubMed, EMBASE, Web of Science, LILACS, Scopus and the Cochrane Library was performed, without language restrictions or specified start date. Pooled data were analyzed by calculating odds ratios (ORs) and 95% confidence intervals (CIs). Quality assessment was performed using the Newcastle-Ottawa Scale (NOS). RESULTS: A total of 1672 studies were screened and 14 met inclusion criteria for the meta-analysis. The overall prevalence of salivary HPV DNA for oral and oropharyngeal carcinoma was 43.2%, and the prevalence of salivary HPV16 genotype was 27.5%. Pooled results showed a significant association between salivary HPV and oral and oropharyngeal cancer (OR = 4.94; 2.82-8.67), oral cancer (OR = 2.58; 1.67-3.99) and oropharyngeal cancer (OR = 17.71; 6.42-48.84). Significant associations were also found between salivary HPV16 and oral and oropharyngeal cancer (OR = 10.07; 3.65-27.82), oral cancer (OR = 2.95; 1.23-7.08) and oropharyngeal cancer (OR = 38.50; 22.43-66.07). CONCLUSIONS: Our meta-analysis demonstrated the association between salivary HPV infection and the incidence of oral and oropharyngeal cancer indicating its value as a predictive indicator.en
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleAssociation of Salivary Human Papillomavirus Infection and Oral and Oropharyngeal Cancer: A Meta-Analysisen
dc.typeJournal Articlees
dc.authorsophosRapado-Gonzalez, O.;Martinez-Reglero, C.;Salgado-Barreira, A.;Rodriguez-Fernandez, A.;Aguin-Losada, S.;Leon-Mateos, L.;Muinelo-Romay, L.;Lopez-Lopez, R.;Suarez-Cunqueiro, M. M.
dc.identifier.doi10.3390/jcm9051305
dc.identifier.pmid32370055
dc.identifier.sophos39903
dc.issue.number5es
dc.journal.titleJournal of Clinical Medicinees
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Oncoloxía médicaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)es
dc.page.initial1305es
dc.rights.accessRightsopenAccess
dc.subject.keywordCHUSes
dc.subject.keywordIDISes
dc.typefidesArtículo de Revisiónes
dc.typesophosArtículo de Revisiónes
dc.volume.number9es


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