Show simple item record

dc.contributor.authorRuperez, A. I.
dc.contributor.authorMesa, M. D.
dc.contributor.authorAnguita-Ruiz, A.
dc.contributor.authorGonzalez-Gil, E. M.
dc.contributor.authorVázquez Cobela, Rocio
dc.contributor.authorMoreno, L. A.
dc.contributor.authorGil, A.
dc.contributor.authorGil-Campos, M.
dc.contributor.authorLeis Trabazo, María Rosaura 
dc.contributor.authorBueno, G.
dc.contributor.authorAguilera, C. M.
dc.date.accessioned2022-05-05T08:28:54Z
dc.date.available2022-05-05T08:28:54Z
dc.date.issued2020
dc.identifier.issn2076-3921
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/32679739es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/16690
dc.description.abstractOxidative stress could help explain the relationship between childhood obesity and a metabolically unhealthy (MU) status. Moreover, puberty could also influence this relationship, since it entails physiological cardiometabolic changes. We aimed to evaluate plasma antioxidants and oxidative stress biomarkers in MU and metabolically healthy (MH) prepubertal and pubertal children and their associations with pro-inflammatory and endothelial damage biomarkers, taking puberty into account. A total of 1444 Spanish children aged 3-17 years (48.9% males, 66% prepubertal, 47.1% with obesity) were recruited. Blood pressure, anthropometric and biochemical parameters were measured, and children were categorized as having a MU or MH status according to risk factors. Retinol, carotenes, tocopherols, total antioxidant capacity (TAC), oxidized low-density lipoprotein and selected pro-inflammatory and endothelial damage biomarkers were analyzed. General linear models adjusted for age, sex, recruitment center and body mass index, partial correlations and stepwise linear regressions were performed. Lower carotenes and tocopherols levels were found in MU than in MH children. Plasma TAC was lower in prepubertal and higher in pubertal children with obesity compared to normal-weight children. Antioxidants and oxidative stress biomarkers showed novel associations with several pro-inflammatory and endothelial damage biomarkers, with pubertal differences, supporting the importance of considering both the antioxidant and oxidative stress status and puberty in the prevention of metabolic diseases in childhood.en
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleAntioxidants and Oxidative Stress in Children: Influence of Puberty and Metabolically Unhealthy Statusen
dc.typeJournal Articlees
dc.authorsophosRuperez, A. I.;Mesa, M. D.;Anguita-Ruiz, A.;Gonzalez-Gil, E. M.;Vazquez-Cobela, R.;Moreno, L. A.;Gil, A.;Gil-Campos, M.;Leis, R.;Bueno, G.;Aguilera, C. M.
dc.identifier.doi10.3390/antiox9070618
dc.identifier.pmid32679739
dc.identifier.sophos39950
dc.issue.number7es
dc.journal.titleAntioxidantses
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Pediatríaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)es
dc.page.initial618es
dc.rights.accessRightsopenAccess
dc.subject.keywordCHUSes
dc.subject.keywordIDISes
dc.typefidesArtículo Originales
dc.typesophosArtículo Originales
dc.volume.number9es


Files in this item

This item appears in the following Collection(s)

Show simple item record

Atribución 4.0 Internacional
Except where otherwise noted, this item's license is described as Atribución 4.0 Internacional