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LAT-1 and GLUT-1 Carrier Expression and Its Prognostic Value in Gastroenteropancreatic Neuroendocrine Tumors
dc.contributor.author | Sampedro-Nunez, M. | |
dc.contributor.author | Bouthelier, A. | |
dc.contributor.author | Serrano-Somavilla, A. | |
dc.contributor.author | Martinez-Hernandez, R. | |
dc.contributor.author | Adrados, M. | |
dc.contributor.author | Martin-Perez, E. | |
dc.contributor.author | de Nova, J. L. M. | |
dc.contributor.author | Cameselle Teijeiro, Jose Manuel | |
dc.contributor.author | Blanco-Carrera, C. | |
dc.contributor.author | Cabezas Agrícola, José Manuel | |
dc.contributor.author | Diaz, J. A. | |
dc.contributor.author | Garcia-Centeno, R. | |
dc.contributor.author | Aragones, J. | |
dc.contributor.author | Marazuela, M. | |
dc.date.accessioned | 2022-05-05T08:28:58Z | |
dc.date.available | 2022-05-05T08:28:58Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 2072-6694 | |
dc.identifier.other | https://www.ncbi.nlm.nih.gov/pubmed/33066332 | es |
dc.identifier.uri | http://hdl.handle.net/20.500.11940/16691 | |
dc.description.abstract | Cancer cells develop mechanisms that increase nutrient uptake, including key nutrient carriers, such as amino acid transporter 1 (LAT-1) and glucose transporter 1 (GLUT-1), regulated by the oxygen-sensing Von Hippel Lindau-hypoxia-inducible factor (VHL-HIF) transcriptional pathway. We aimed to analyze these metabolic players in gastroenteropancreatic neuroendocrine tumors (GEP-NET) and correlate them with tumor malignancy and progression. LAT-1, GLUT-1, and pVHL expression was analyzed in 116 GEP-NETs and 48 peritumoral tissue samples by immunohistochemistry. LAT-1 was stably silenced using specific shRNA in the human NET BON cell line. LAT-1 expression was significantly increased in tumor tissue compared to non-tumor tissue in both gastrointestinal (67% vs. 44%) and pancreatic NETs (54% vs. 31%). Similarly, GLUT-1 was substantially elevated in gastrointestinal (74% vs. 19%) and pancreatic (58% vs. 4%) NETs. In contrast, pVHL expression was decreased (85% vs. 58%) in pancreatic NETs. Tumors with metastases at diagnosis displayed increased LAT-1 and GLUT-1 and decreased pVHL expression (p < 0.001). In accordance with these data, silencing LAT-1 curtailed cell proliferation in BON cells. These findings suggest that specific mechanisms that increase nutrient uptake, such as LAT-1 and GLUT-1, are increased in GEP-NETs, whereas pVHL is decreased. These markers might be related to the proliferation and metastatic capacity of these tumors. | en |
dc.rights | Atribución 4.0 Internacional | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.title | LAT-1 and GLUT-1 Carrier Expression and Its Prognostic Value in Gastroenteropancreatic Neuroendocrine Tumors | en |
dc.type | Journal Article | es |
dc.authorsophos | Sampedro-Nunez, M.;Bouthelier, A.;Serrano-Somavilla, A.;Martinez-Hernandez, R.;Adrados, M.;Martin-Perez, E.;de Nova, J. L. M.;Cameselle-Teijeiro, J. M.;Blanco-Carrera, C.;Cabezas-Agricola, J. M.;Diaz, J. A.;Garcia-Centeno, R.;Aragones, J.;Marazuela, M. | |
dc.identifier.doi | 10.3390/cancers12102968 | |
dc.identifier.pmid | 33066332 | |
dc.identifier.sophos | 39954 | |
dc.issue.number | 10 | es |
dc.journal.title | Cancers (Basel) | es |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Anatomía Patolóxica | es |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Endocrinoloxía | es |
dc.page.initial | 2968 | es |
dc.rights.accessRights | openAccess | |
dc.subject.keyword | CHUS | es |
dc.typefides | Artículo Original | es |
dc.typesophos | Artículo Original | es |
dc.volume.number | 12 | es |
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