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dc.contributor.authorTubio Pérez, Ramón
dc.contributor.authorTorres Durán, María Luisa 
dc.contributor.authorPerez-Rios, M.
dc.contributor.authorFernández Villar, José Alberto 
dc.contributor.authorRuano-Ravina, A.
dc.date.accessioned2022-05-05T08:29:46Z
dc.date.available2022-05-05T08:29:46Z
dc.date.issued2020
dc.identifier.issn2305-5847
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/33313216es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/16703
dc.description.abstractEmphysema and lung cancer (LC) are two diseases which share common risk factors, e.g., smoking. In recent years, many studies have sought to analyse this association. By way of illustration, we conducted a review of the scientific literature of the studies published to date, whose main designated aim was to demonstrate the relationship between emphysema and LC, and this association's influence on the histology, prognosis and molecular mechanisms responsible. We included over 40 studies (ranging from case-control and cohort studies to systematic reviews and meta-analyses), which highlight the association between emphysema and LC, independently of smoking habit. These studies also report a possible influence on histology, with adenocarcinoma being the most frequent lineage, and an association with poor prognosis, which affects both survival and post-operative complications. Oxidative stress, which generates chronic inflammatory status as well as the presence of certain polymorphisms in various genes (CYP1A1, TERT, CLPTM1L, ERK), gives rise-in the case of patients with emphysema-to alteration of cellular repair mechanisms, which in turn favours the proliferation of neoplastic epithelial cells responsible for the origin of LC.en
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleLung emphysema and lung cancer: what do we know about it?en
dc.typeJournal Articlees
dc.authorsophosTubio-Perez, R. A.;Torres-Duran, M.;Perez-Rios, M.;Fernandez-Villa, A.;Ruano-Ravina, A.
dc.identifier.doi10.21037/atm-20-1180
dc.identifier.pmid33313216
dc.identifier.sophos40007
dc.issue.number21es
dc.journal.titleAnnals Translational of Medicinees
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Vigo - Complexo Hospitalario Universitario de Vigo::Neumoloxíaes
dc.page.initial1471es
dc.rights.accessRightsopenAccess
dc.subject.keywordCHUVIes
dc.typefidesArtículo de Revisiónes
dc.typesophosArtículo de Revisiónes
dc.volume.number8es


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Attribution-NonCommercial-NoDerivatives 4.0 International
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