Drug Delivery to the Posterior Segment of the Eye: Biopharmaceutic and Pharmacokinetic Considerations
dc.contributor.author | Fernández Varela, Ramon | |
dc.contributor.author | Diaz Tomé, Victoria | |
dc.contributor.author | Luaces Rodríguez, Andrea | |
dc.contributor.author | Conde-Penedo, A. | |
dc.contributor.author | García Otero, Xurxo | |
dc.contributor.author | Luzardo-Alvarez, A. | |
dc.contributor.author | Fernández Ferreiro, Anxo | |
dc.contributor.author | Otero Espinar, Francisco | |
dc.date.accessioned | 2022-05-19T08:31:55Z | |
dc.date.available | 2022-05-19T08:31:55Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 1999-4923 | |
dc.identifier.other | https://www.ncbi.nlm.nih.gov/pubmed/32188045 | es |
dc.identifier.uri | http://hdl.handle.net/20.500.11940/16721 | |
dc.description.abstract | The treatment of the posterior-segment ocular diseases, such as age-related eye diseases (AMD) or diabetic retinopathy (DR), present a challenge for ophthalmologists due to the complex anatomy and physiology of the eye. This specialized organ is composed of various static and dynamic barriers that restrict drug delivery into the target site of action. Despite numerous efforts, effective intraocular drug delivery remains unresolved and, therefore, it is highly desirable to improve the current treatments of diseases affecting the posterior cavity. This review article gives an overview of pharmacokinetic and biopharmaceutics aspects for the most commonly-used ocular administration routes (intravitreal, topical, systemic, and periocular), including information of the absorption, distribution, and elimination, as well as the benefits and limitations of each one. This article also encompasses different conventional and novel drug delivery systems designed and developed to improve drug pharmacokinetics intended for the posterior ocular segment treatment. | en |
dc.rights | Atribución 4.0 Internacional | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.title | Drug Delivery to the Posterior Segment of the Eye: Biopharmaceutic and Pharmacokinetic Considerations | en |
dc.type | Journal Article | es |
dc.authorsophos | Varela-Fernandez, R.;Diaz-Tome, V.;Luaces-Rodriguez, A.;Conde-Penedo, A.;Garcia-Otero, X.;Luzardo-Alvarez, A.;Fernandez-Ferreiro, A.;Otero-Espinar, F. J. | |
dc.identifier.doi | 10.3390/pharmaceutics12030269 | |
dc.identifier.pmid | 32188045 | |
dc.identifier.sophos | 40020 | |
dc.issue.number | 3 | es |
dc.journal.title | Pharmaceutics | es |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Farmacia | es |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Neuroloxía | es |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS) | es |
dc.rights.accessRights | openAccess | |
dc.subject.keyword | CHUS | es |
dc.subject.keyword | IDIS | es |
dc.typefides | Artículo de Revisión | es |
dc.typesophos | Artículo de Revisión | es |
dc.volume.number | 12 | es |
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