MTOR pathway is involved in energy homeostasis regulation as a part of the gut–brain axis
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Identificadores
URI: http://hdl.handle.net/20.500.11940/16725
PMID: 32784967
DOI: 10.3390/ijms21165715
ISSN: 1422-0067
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Fecha de publicación
2020Título de revista
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Tipo de contenido
Journal Article
DeCS
ghrelina | animales | mucosa gástrica | glucosa | glicólisis | tejido adiposo | transducción de señales | metabolismo lipídico | homeostasis | hígado | humanos | hipotálamo | ingestión de alimentosMeSH
Adipose Tissue | Hypothalamus | Liver | Lipid Metabolism | Glycolysis | Signal Transduction | Animals | Glucose | Eating | Homeostasis | Humans | Gastric Mucosa | GhrelinResumen
Mammalian, or mechanic, target of rapamycin (mTOR) signaling is a crucial factor in the regulation of the energy balance that functions as an energy sensor in the body. The present review explores how the mTOR/S6k intracellular pathway is involved in modulating the production of different signals such as ghrelin and nesfatin-1 in the gastrointestinal tract to regulate food intake and body weight. The role of gastric mTOR signaling in different physiological processes was studied in depth through different genetic models that allow the modulation of mTOR signaling in the stomach and specifically in gastric X/A type cells. It has been described that mTOR signaling in X/A-like gastric cells has a relevant role in the regulation of glucose and lipid homeostasis due to its interaction with different organs such as liver and adipose tissue. These findings highlight possible therapeutic strategies, with the gut-brain axis being one of the most promising targets in the treatment of obesity.
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