Increased Th17-Related Cytokine Serum Levels in Patients With Multiple Polyps of Unexplained Origin
Alustiza, M.; Hernández-Illán, E.; Juárez, M.; Giner-Calabuig, M.; Mira, C.; Martínez-Roca, A.; Bujanda, L.; Rodríguez-Moranta, F.; Cubiella Fernández, Joaquín; De Castro Parga, María Luisa; Marín-Gabriel, J. C.; Herreros-de-Tejada, A.; Fernández-Bañares, F.; Nicolás-Pérez, D.; Giménez, P.; Martínez-Cardona, C.; Francés, R.; Murcia, O.; Jover, R.
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CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
Type of content
DeCSestudios de casos y controles | anciano | mucosa intestinal | estudios prospectivos | citocinas | pólipos del colon | colon | mediana edad | humanos | colonoscopia | inflamación | células Th17
MeSHMiddle Aged | Humans | Cytokines | Colon | Intestinal Mucosa | Th17 Cells | Prospective Studies | Colonic Polyps | Case-Control Studies | Aged | Inflammation | Colonoscopy
OBJECTIVES: Most patients with multiple colonic polyps do not have a known genetic or hereditary origin. Our aim was to analyze the presence of inflammatory cytokines and levels of glucose, insulin, and C-reactive protein (CRP) in patients with multiple colonic polyps. METHODS: Eighty-three patients with 10 or more adenomatous or serrated polyps and 53 control people with normal colonoscopy were included. Smoking habits were registered, and glucose, CRP, and basal insulin in the serum/blood were measured. Quantification of IL-2, IL-4, IL-6, IL-10, IL-11, IL-17A, and IL-23 cytokine levels in the serum was performed by a high-sensitivity enzyme-linked immunosorbent assay. RESULTS: Smoking and diabetes were more prevalent in those with colonic polyps than in the control people (67% vs 16%, P = 0.001; 11% vs 2%, P = 0.048). In addition, the cytokine serum levels were higher, i.e., IL-2 (P = 0.001), IL-4 (P = 0.001), IL-6 (P = 0.001), IL-17A (P = 0.001), IL-23 (P = 0.014), and CRP (P = 0.003). Adjusting for sex, smoking, and diabetes in a multivariate analysis, IL-2, IL-4, IL-6, IL-17A, and IL-23 remained independently elevated in cases with multiple polyps. DISCUSSION: These results indicate that immune responses mediated by Th17 cells may be involved in the pathogenesis of multiple colonic polyps.