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Leukocyte Associated Immunoglobulin Like Receptor 1 Regulation and Function on Monocytes and Dendritic Cells During Inflammation
dc.contributor.author | Carvalheiro, T. | |
dc.contributor.author | García Pérez, Samuel | |
dc.contributor.author | Pascoal Ramos, M. I. | |
dc.contributor.author | Giovannone, B. | |
dc.contributor.author | Radstake, Trdj | |
dc.contributor.author | Marut, W. | |
dc.contributor.author | Meyaard, L. | |
dc.date.accessioned | 2022-05-19T08:33:11Z | |
dc.date.available | 2022-05-19T08:33:11Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 1664-3224 | |
dc.identifier.other | https://www.ncbi.nlm.nih.gov/pubmed/32973751 | es |
dc.identifier.uri | http://hdl.handle.net/20.500.11940/16737 | |
dc.description.abstract | Inhibitory receptors are crucial immune regulators and are essential to prevent exacerbated responses, thus contributing to immune homeostasis. Leukocyte associated immunoglobulin like receptor 1 (LAIR-1) is an immune inhibitory receptor which has collagen and collagen domain containing proteins as ligands. LAIR-1 is broadly expressed on immune cells and has a large availability of ligands in both circulation and tissues, implicating a need for tight regulation of this interaction. In the current study, we sought to examine the regulation and function of LAIR-1 on monocyte, dendritic cell (DC) and macrophage subtypes, using different in vitro models. We found that LAIR-1 is highly expressed on intermediate monocytes as well as on plasmacytoid DCs. LAIR-1 is also expressed on skin immune cells, mainly on tissue CD14(+) cells, macrophages and CD1c(+) DCs. In vitro, monocyte and type-2 conventional DC stimulation leads to LAIR-1 upregulation, which may reflect the importance of LAIR-1 as negative regulator under inflammatory conditions. Indeed, we demonstrate that LAIR-1 ligation on monocytes inhibits toll like receptor (TLR)4 and Interferon (IFN)-alpha- induced signals. Furthermore, LAIR-1 is downregulated on GM-CSF and IFN-gamma monocyte-derived macrophages and monocyte-derived DCs. In addition, LAIR-1 triggering during monocyte derived-DC differentiation results in significant phenotypic changes, as well as a different response to TLR4 and IFN-alpha stimulation. This indicates a role for LAIR-1 in skewing DC function, which impacts the cytokine expression profile of these cells. In conclusion, we demonstrate that LAIR-1 is consistently upregulated on monocytes and DC during the inflammatory phase of the immune response and tends to restore its expression during the resolution phase. Under inflammatory conditions, LAIR-1 has an inhibitory function, pointing toward to a potential intervention opportunity targeting LAIR-1 in inflammatory conditions. | en |
dc.rights | Atribución 4.0 Internacional | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject.mesh | Dendritic Cells | * |
dc.subject.mesh | Humans | * |
dc.subject.mesh | Cytokines | * |
dc.subject.mesh | Macrophages | * |
dc.subject.mesh | Cells | * |
dc.subject.mesh | Signal Transduction | * |
dc.subject.mesh | Gene Expression Regulation | * |
dc.subject.mesh | Monocytes | * |
dc.subject.mesh | Inflammation Mediators | * |
dc.subject.mesh | Inflammation | * |
dc.title | Leukocyte Associated Immunoglobulin Like Receptor 1 Regulation and Function on Monocytes and Dendritic Cells During Inflammation | en |
dc.type | Journal Article | es |
dc.authorsophos | Carvalheiro, T.;Garcia, S.;Pascoal Ramos, M. I.;Giovannone, B.;Radstake, Trdj;Marut, W.;Meyaard, L. | |
dc.identifier.doi | 10.3389/fimmu.2020.01793 | |
dc.identifier.pmid | 32973751 | |
dc.identifier.sophos | 40461 | |
dc.journal.title | Frontiers in Immunology | es |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Vigo - Complexo Hospitalario Universitario de Vigo::Reumatoloxía | es |
dc.page.initial | 1793 | es |
dc.rights.accessRights | openAccess | |
dc.subject.decs | mediadores de la inflamación | * |
dc.subject.decs | citocinas | * |
dc.subject.decs | monocitos | * |
dc.subject.decs | humanos | * |
dc.subject.decs | células | * |
dc.subject.decs | inflamación | * |
dc.subject.decs | regulación de la expresión génica | * |
dc.subject.decs | transducción de señales | * |
dc.subject.decs | macrófagos | * |
dc.subject.decs | células dendríticas | * |
dc.subject.keyword | CHUVI | es |
dc.typefides | Artículo Original | es |
dc.typesophos | Artículo Original | es |
dc.volume.number | 11 | es |