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dc.contributor.authorCarvalheiro, T.
dc.contributor.authorGarcía Pérez, Samuel
dc.contributor.authorPascoal Ramos, M. I.
dc.contributor.authorGiovannone, B.
dc.contributor.authorRadstake, Trdj
dc.contributor.authorMarut, W.
dc.contributor.authorMeyaard, L.
dc.date.accessioned2022-05-19T08:33:11Z
dc.date.available2022-05-19T08:33:11Z
dc.date.issued2020
dc.identifier.issn1664-3224
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/32973751es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/16737
dc.description.abstractInhibitory receptors are crucial immune regulators and are essential to prevent exacerbated responses, thus contributing to immune homeostasis. Leukocyte associated immunoglobulin like receptor 1 (LAIR-1) is an immune inhibitory receptor which has collagen and collagen domain containing proteins as ligands. LAIR-1 is broadly expressed on immune cells and has a large availability of ligands in both circulation and tissues, implicating a need for tight regulation of this interaction. In the current study, we sought to examine the regulation and function of LAIR-1 on monocyte, dendritic cell (DC) and macrophage subtypes, using different in vitro models. We found that LAIR-1 is highly expressed on intermediate monocytes as well as on plasmacytoid DCs. LAIR-1 is also expressed on skin immune cells, mainly on tissue CD14(+) cells, macrophages and CD1c(+) DCs. In vitro, monocyte and type-2 conventional DC stimulation leads to LAIR-1 upregulation, which may reflect the importance of LAIR-1 as negative regulator under inflammatory conditions. Indeed, we demonstrate that LAIR-1 ligation on monocytes inhibits toll like receptor (TLR)4 and Interferon (IFN)-alpha- induced signals. Furthermore, LAIR-1 is downregulated on GM-CSF and IFN-gamma monocyte-derived macrophages and monocyte-derived DCs. In addition, LAIR-1 triggering during monocyte derived-DC differentiation results in significant phenotypic changes, as well as a different response to TLR4 and IFN-alpha stimulation. This indicates a role for LAIR-1 in skewing DC function, which impacts the cytokine expression profile of these cells. In conclusion, we demonstrate that LAIR-1 is consistently upregulated on monocytes and DC during the inflammatory phase of the immune response and tends to restore its expression during the resolution phase. Under inflammatory conditions, LAIR-1 has an inhibitory function, pointing toward to a potential intervention opportunity targeting LAIR-1 in inflammatory conditions.en
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.meshDendritic Cells*
dc.subject.meshHumans*
dc.subject.meshCytokines*
dc.subject.meshMacrophages*
dc.subject.meshCells*
dc.subject.meshSignal Transduction*
dc.subject.meshGene Expression Regulation*
dc.subject.meshMonocytes*
dc.subject.meshInflammation Mediators*
dc.subject.meshInflammation*
dc.titleLeukocyte Associated Immunoglobulin Like Receptor 1 Regulation and Function on Monocytes and Dendritic Cells During Inflammationen
dc.typeJournal Articlees
dc.authorsophosCarvalheiro, T.;Garcia, S.;Pascoal Ramos, M. I.;Giovannone, B.;Radstake, Trdj;Marut, W.;Meyaard, L.
dc.identifier.doi10.3389/fimmu.2020.01793
dc.identifier.pmid32973751
dc.identifier.sophos40461
dc.journal.titleFrontiers in Immunologyes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Vigo - Complexo Hospitalario Universitario de Vigo::Reumatoloxíaes
dc.page.initial1793es
dc.rights.accessRightsopenAccess
dc.subject.decsmediadores de la inflamación*
dc.subject.decscitocinas*
dc.subject.decsmonocitos*
dc.subject.decshumanos*
dc.subject.decscélulas*
dc.subject.decsinflamación*
dc.subject.decsregulación de la expresión génica*
dc.subject.decstransducción de señales*
dc.subject.decsmacrófagos*
dc.subject.decscélulas dendríticas*
dc.subject.keywordCHUVIes
dc.typefidesArtículo Originales
dc.typesophosArtículo Originales
dc.volume.number11es


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Atribución 4.0 Internacional
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