Mostrar el registro sencillo del ítem

dc.contributor.authorDionisio, M. R.
dc.contributor.authorVieira, A. F.
dc.contributor.authorCarvalho, R.
dc.contributor.authorConde, I.
dc.contributor.authorOliveira, M.
dc.contributor.authorGomes, M.
dc.contributor.authorPinto, M. T.
dc.contributor.authorPereira, P.
dc.contributor.authorPimentel, J.
dc.contributor.authorSouza, C.
dc.contributor.authorMarques, M. M. C.
dc.contributor.authorda Silva, V. D.
dc.contributor.authorBarroso, A.
dc.contributor.authorPreto, D.
dc.contributor.authorCameselle Teijeiro, Jorge 
dc.contributor.authorSchmitt, F.
dc.contributor.authorRibeiro, A. S.
dc.contributor.authorParedes, J.
dc.date.accessioned2022-05-19T08:34:11Z
dc.date.available2022-05-19T08:34:11Z
dc.date.issued2020
dc.identifier.issn2073-440
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/33182375es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/16749
dc.description.abstractBrain metastases remain an unmet clinical need in breast oncology, being frequently found in HER2-overexpressing and triple-negative carcinomas. These tumors were reported to be highly cancer stem-like cell-enriched, suggesting that brain metastases probably arise by the seeding of cancer cells with stem features. Accordingly, we found that brain-tropic breast cancer cells show increased stem cell activity and tumorigenic capacity in the chick embryo choriallantoic membrane when compared to the parental cell line. These observations were supported by a significant increase in their stem cell frequency and by the enrichment for the breast cancer stem cell (BCSC) phenotype CD44(+)CD24(-/low). Based on this data, the expression of BCSC markers (CD44, CD49f, P-cadherin, EpCAM, and ALDH1) was determined and found to be significantly enriched in breast cancer brain metastases when compared to primary tumors. Therefore, a brain (BR)-BCSC signature was defined (3-5 BCSC markers), which showed to be associated with decreased brain metastases-free and overall survival. Interestingly, this signature significantly predicted a worse prognosis in lymph node-positive patients, acting as an independent prognostic factor. Thus, an enrichment of a BCSC signature was found in brain metastases, which can be used as a new prognostic factor in clinically challenging breast cancer patients.en
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.meshProportional Hazards Models*
dc.subject.meshBrain Neoplasms*
dc.subject.meshMultivariate Analysis*
dc.subject.meshBreast Neoplasms*
dc.subject.meshChick Embryo*
dc.subject.meshMice*
dc.subject.meshLymph Nodes*
dc.subject.meshAnimals*
dc.subject.meshChorioallantoic Membrane*
dc.subject.meshCell Line*
dc.subject.meshHumans*
dc.subject.meshCarcinogenesis*
dc.subject.meshNeoplastic Stem Cells*
dc.subject.meshKaplan-Meier Estimate*
dc.subject.meshPrognosis*
dc.titleBR-BCSC Signature: The Cancer Stem Cell Profile Enriched in Brain Metastases that Predicts a Worse Prognosis in Lymph Node-Positive Breast Canceren
dc.typeJournal Articlees
dc.authorsophosDionisio, M. R.;Vieira, A. F.;Carvalho, R.;Conde, I.;Oliveira, M.;Gomes, M.;Pinto, M. T.;Pereira, P.;Pimentel, J.;Souza, C.;Marques, M. M. C.;da Silva, V. D.;Barroso, A.;Preto, D.;Cameselle-Teijeiro, J. F.;Schmitt, F.;Ribeiro, A. S.;Paredes, J.
dc.identifier.doi10.3390/cells9112442
dc.identifier.pmid33182375
dc.identifier.sophos40617
dc.issue.number11es
dc.journal.titleCellses
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Vigo - Complexo Hospitalario Universitario de Vigo::Anatomía Patolóxicaes
dc.rights.accessRightsopenAccess
dc.subject.decspronóstico*
dc.subject.decsanimales*
dc.subject.decsanálisis multifactorial*
dc.subject.decsneoplasias cerebrales*
dc.subject.decscélulas madre neoplásicas*
dc.subject.decsganglios linfáticos*
dc.subject.decsneoplasias de la mama*
dc.subject.decscarcinogénesis*
dc.subject.decsembrión de pollo*
dc.subject.decsmembrana corioalantoides*
dc.subject.decsestimación de Kaplan-Meier*
dc.subject.decslínea celular*
dc.subject.decshumanos*
dc.subject.decsmodelos de riesgos proporcionales*
dc.subject.decsratones*
dc.subject.keywordCHUVIes
dc.typefidesArtículo Originales
dc.typesophosArtículo Originales
dc.volume.number9es


Ficheros en el ítem

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

Atribución 4.0 Internacional
Excepto si se señala otra cosa, la licencia del ítem se describe como Atribución 4.0 Internacional