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BR-BCSC Signature: The Cancer Stem Cell Profile Enriched in Brain Metastases that Predicts a Worse Prognosis in Lymph Node-Positive Breast Cancer
dc.contributor.author | Dionisio, M. R. | |
dc.contributor.author | Vieira, A. F. | |
dc.contributor.author | Carvalho, R. | |
dc.contributor.author | Conde, I. | |
dc.contributor.author | Oliveira, M. | |
dc.contributor.author | Gomes, M. | |
dc.contributor.author | Pinto, M. T. | |
dc.contributor.author | Pereira, P. | |
dc.contributor.author | Pimentel, J. | |
dc.contributor.author | Souza, C. | |
dc.contributor.author | Marques, M. M. C. | |
dc.contributor.author | da Silva, V. D. | |
dc.contributor.author | Barroso, A. | |
dc.contributor.author | Preto, D. | |
dc.contributor.author | Cameselle Teijeiro, Jorge | |
dc.contributor.author | Schmitt, F. | |
dc.contributor.author | Ribeiro, A. S. | |
dc.contributor.author | Paredes, J. | |
dc.date.accessioned | 2022-05-19T08:34:11Z | |
dc.date.available | 2022-05-19T08:34:11Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 2073-440 | |
dc.identifier.other | https://www.ncbi.nlm.nih.gov/pubmed/33182375 | es |
dc.identifier.uri | http://hdl.handle.net/20.500.11940/16749 | |
dc.description.abstract | Brain metastases remain an unmet clinical need in breast oncology, being frequently found in HER2-overexpressing and triple-negative carcinomas. These tumors were reported to be highly cancer stem-like cell-enriched, suggesting that brain metastases probably arise by the seeding of cancer cells with stem features. Accordingly, we found that brain-tropic breast cancer cells show increased stem cell activity and tumorigenic capacity in the chick embryo choriallantoic membrane when compared to the parental cell line. These observations were supported by a significant increase in their stem cell frequency and by the enrichment for the breast cancer stem cell (BCSC) phenotype CD44(+)CD24(-/low). Based on this data, the expression of BCSC markers (CD44, CD49f, P-cadherin, EpCAM, and ALDH1) was determined and found to be significantly enriched in breast cancer brain metastases when compared to primary tumors. Therefore, a brain (BR)-BCSC signature was defined (3-5 BCSC markers), which showed to be associated with decreased brain metastases-free and overall survival. Interestingly, this signature significantly predicted a worse prognosis in lymph node-positive patients, acting as an independent prognostic factor. Thus, an enrichment of a BCSC signature was found in brain metastases, which can be used as a new prognostic factor in clinically challenging breast cancer patients. | en |
dc.rights | Atribución 4.0 Internacional | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject.mesh | Proportional Hazards Models | * |
dc.subject.mesh | Brain Neoplasms | * |
dc.subject.mesh | Multivariate Analysis | * |
dc.subject.mesh | Breast Neoplasms | * |
dc.subject.mesh | Chick Embryo | * |
dc.subject.mesh | Mice | * |
dc.subject.mesh | Lymph Nodes | * |
dc.subject.mesh | Animals | * |
dc.subject.mesh | Chorioallantoic Membrane | * |
dc.subject.mesh | Cell Line | * |
dc.subject.mesh | Humans | * |
dc.subject.mesh | Carcinogenesis | * |
dc.subject.mesh | Neoplastic Stem Cells | * |
dc.subject.mesh | Kaplan-Meier Estimate | * |
dc.subject.mesh | Prognosis | * |
dc.title | BR-BCSC Signature: The Cancer Stem Cell Profile Enriched in Brain Metastases that Predicts a Worse Prognosis in Lymph Node-Positive Breast Cancer | en |
dc.type | Journal Article | es |
dc.authorsophos | Dionisio, M. R.;Vieira, A. F.;Carvalho, R.;Conde, I.;Oliveira, M.;Gomes, M.;Pinto, M. T.;Pereira, P.;Pimentel, J.;Souza, C.;Marques, M. M. C.;da Silva, V. D.;Barroso, A.;Preto, D.;Cameselle-Teijeiro, J. F.;Schmitt, F.;Ribeiro, A. S.;Paredes, J. | |
dc.identifier.doi | 10.3390/cells9112442 | |
dc.identifier.pmid | 33182375 | |
dc.identifier.sophos | 40617 | |
dc.issue.number | 11 | es |
dc.journal.title | Cells | es |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Vigo - Complexo Hospitalario Universitario de Vigo::Anatomía Patolóxica | es |
dc.rights.accessRights | openAccess | |
dc.subject.decs | pronóstico | * |
dc.subject.decs | animales | * |
dc.subject.decs | análisis multifactorial | * |
dc.subject.decs | neoplasias cerebrales | * |
dc.subject.decs | células madre neoplásicas | * |
dc.subject.decs | ganglios linfáticos | * |
dc.subject.decs | neoplasias de la mama | * |
dc.subject.decs | carcinogénesis | * |
dc.subject.decs | embrión de pollo | * |
dc.subject.decs | membrana corioalantoides | * |
dc.subject.decs | estimación de Kaplan-Meier | * |
dc.subject.decs | línea celular | * |
dc.subject.decs | humanos | * |
dc.subject.decs | modelos de riesgos proporcionales | * |
dc.subject.decs | ratones | * |
dc.subject.keyword | CHUVI | es |
dc.typefides | Artículo Original | es |
dc.typesophos | Artículo Original | es |
dc.volume.number | 9 | es |