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Genomic Characterization of Escherichia coli Isolates Belonging to a New Hybrid aEPEC/ExPEC Pathotype O153:H10-A-ST10 eae-beta1 Occurred in Meat, Poultry, Wildlife and Human Diarrheagenic Samples
dc.contributor.author | Díaz-Jiménez, D. | |
dc.contributor.author | García-Meniño, I. | |
dc.contributor.author | Herrera, A. | |
dc.contributor.author | García, V. | |
dc.contributor.author | López-Beceiro, A.M. | |
dc.contributor.author | Alonso García, Pilar | |
dc.contributor.author | Blanco, J. | |
dc.contributor.author | Mora, A. | |
dc.date.accessioned | 2022-05-23T08:38:21Z | |
dc.date.available | 2022-05-23T08:38:21Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 2079-6382 | |
dc.identifier.other | https://www.ncbi.nlm.nih.gov/pubmed/32316613 | es |
dc.identifier.uri | http://hdl.handle.net/20.500.11940/16800 | |
dc.description.abstract | Different surveillance studies (2005-2015) in northwest Spain revealed the presence of eae-positive isolates of Escherichia coli O153:H10 in meat for human consumption, poultry farm, wildlife and human diarrheagenic samples. The aim of this study was to explore the genetic and genomic relatedness between human and animal/meat isolates, as well as the mechanism of its persistence. We also wanted to know whether it was a geographically restricted lineage, or whether it was also reported elsewhere. Conventional typing showed that 32 isolates were O153:H10-A-ST10 fimH54, fimAvMT78, traT and eae-beta1. Amongst these, 21 were CTX-M-32 or SHV-12 producers. The PFGE XbaI-macrorestriction comparison showed high similarity (>85%). The plasmidome analysis revealed a stable combination of IncF (F2:A-:B-), IncI1 (STunknown) and IncX1 plasmid types, together with non-conjugative Col-like plasmids. The core genome investigation based on the cgMLST scheme from EnteroBase proved close relatedness between isolates of human and animal origin. Our results demonstrate that a hybrid MDR aEPEC/ExPEC of the clonal group O153:H10-A-ST10 (CH11-54) is circulating in our region within different hosts, including wildlife. It seems implicated in human diarrhea via meat transmission, and in the spreading of ESBL genes (mainly of CTX-M-32 type). We found genomic evidence of a related hybrid aEPEC/ExPEC in at least one other country. | en |
dc.rights | Atribución 4.0 Internacional | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.title | Genomic Characterization of Escherichia coli Isolates Belonging to a New Hybrid aEPEC/ExPEC Pathotype O153:H10-A-ST10 eae-beta1 Occurred in Meat, Poultry, Wildlife and Human Diarrheagenic Samples | en |
dc.type | Journal Article | es |
dc.authorsophos | Díaz-Jiménez, D.;García-Meniño, I.;Herrera, A.;García, V.;López-Beceiro, A.M.;Alonso, M.P.;Blanco, J.;Mora, A. | |
dc.identifier.doi | 10.3390/antibiotics9040192 | |
dc.identifier.pmid | 32316613 | |
dc.identifier.sophos | 42928 | |
dc.issue.number | 4 | es |
dc.journal.title | Antibiotics (Basel, Switzerland) | es |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Lugo, Cervo e Monforte de lemos - Complexo Hospitalario Universitario Lucus Augusti::Microbioloxía | es |
dc.page.final | 192 | es |
dc.relation.publisherversion | https://mdpi-res.com/d://attachment/antibiotics/antibiotics-09-00192/article://deploy/antibiotics-09-00192.pdf | es |
dc.rights.accessRights | openAccess | |
dc.subject.keyword | HULA | es |
dc.typefides | Artículo Original | es |
dc.typesophos | Artículo Original | es |
dc.volume.number | 9 | es |
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