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Diagnosis and treatment outcomes of adult tuberculosis in an urban setting with high HIV prevalence in Sierra Leone: A retrospective study
dc.contributor.author | Lakoh, S. | |
dc.contributor.author | Jiba, D. F. | |
dc.contributor.author | Adekanmbi, O. | |
dc.contributor.author | Poveda López, Eva | |
dc.contributor.author | Sahr, F. | |
dc.contributor.author | Deen, G. F. | |
dc.contributor.author | Foray, L. M. | |
dc.contributor.author | Gashau, W. | |
dc.contributor.author | Hoffmann, C. J. | |
dc.contributor.author | Salata, R. A. | |
dc.contributor.author | Yendewa, G. A. | |
dc.date.accessioned | 2022-05-24T12:13:21Z | |
dc.date.available | 2022-05-24T12:13:21Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 1201-9712 | |
dc.identifier.other | https://www.ncbi.nlm.nih.gov/pubmed/32339724 | es |
dc.identifier.uri | http://hdl.handle.net/20.500.11940/16818 | |
dc.description.abstract | OBJECTIVE: To assess the diagnosis, treatment outcomes, and predictors of mortality in adult tuberculosis (TB) patients in an urban setting with a high HIV prevalence. METHODS: A retrospective study was conducted of adult TB patients aged >/=15 years who were treated at Connaught Hospital in Freetown, Sierra Leone from January through December 2017. Multivariate logistic regression was used to identify predictors of mortality. RESULTS: Of 1127 TB cases notified in 2017, 1105 (98%) were tested for HIV, yielding a TB/HIV co-infection rate of 32.0%. Only HIV-tested cases (n=1105) were included in the final analysis. The majority were male (69.3%), aged 25-34 years (29.2%), and had pulmonary TB (96.3%). Treatment outcomes were as follows: 29.0% cured, 29.0% completed, 0.5% treatment failure, 24.2% lost to follow-up, 12.8% transferred/not evaluated, and 4.5% died. The majority of deaths (80.0%, 40/50) occurred within 2 months of TB treatment initiation. Age 65 years or older (adjusted odds ratio 3.48, 95% confidence interval 1.15-10.56; p=0.027) and HIV-positive status (adjusted odds ratio 3.50, 95% confidence interval 1.72-7.12; p=0.001) were independent predictors of mortality. CONCLUSIONS: Suboptimal TB treatment outcomes were observed in Sierra Leone in 2017. More local and international action is warranted to help achieve the 2035 global TB elimination targets. | en |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject.mesh | Adult | * |
dc.subject.mesh | Middle Aged | * |
dc.subject.mesh | Adolescent | * |
dc.subject.mesh | Coinfection | * |
dc.subject.mesh | Tuberculosis | * |
dc.subject.mesh | Prevalence | * |
dc.subject.mesh | Humans | * |
dc.subject.mesh | Treatment Outcome | * |
dc.subject.mesh | Diagnosis | * |
dc.subject.mesh | Young Adult | * |
dc.subject.mesh | Aged | * |
dc.subject.mesh | Retrospective Studies | * |
dc.subject.mesh | HIV Infections | * |
dc.subject.mesh | Cities | * |
dc.title | Diagnosis and treatment outcomes of adult tuberculosis in an urban setting with high HIV prevalence in Sierra Leone: A retrospective study | en |
dc.type | Journal Article | es |
dc.authorsophos | Lakoh, S.;Jiba, D. F.;Adekanmbi, O.;Poveda, E.;Sahr, F.;Deen, G. F.;Foray, L. M.;Gashau, W.;Hoffmann, C. J.;Salata, R. A.;Yendewa, G. A. | |
dc.identifier.doi | 10.1016/j.ijid.2020.04.038 | |
dc.identifier.pmid | 32339724 | |
dc.identifier.sophos | 41329 | |
dc.journal.title | INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | es |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Biomédica Ourense-Pontevedra-Vigo (IBI) | es |
dc.page.initial | 112 | es |
dc.page.final | 118 | es |
dc.rights.accessRights | openAccess | |
dc.subject.decs | resultado del tratamiento | * |
dc.subject.decs | prevalencia | * |
dc.subject.decs | estudios retrospectivos | * |
dc.subject.decs | mediana edad | * |
dc.subject.decs | coinfección | * |
dc.subject.decs | adulto | * |
dc.subject.decs | infecciones por VIH | * |
dc.subject.decs | anciano | * |
dc.subject.decs | tuberculosis | * |
dc.subject.decs | diagnóstico | * |
dc.subject.decs | ciudades | * |
dc.subject.decs | adulto joven | * |
dc.subject.decs | humanos | * |
dc.subject.decs | adolescente | * |
dc.subject.keyword | IISGS | es |
dc.typefides | Artículo Original | es |
dc.typesophos | Artículo Original | es |
dc.volume.number | 96. | es |
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