dc.contributor.author | Bande Rodriguez, Manuel Francisco | |
dc.contributor.author | Fernández Marta, Beatriz | |
dc.contributor.author | Lago Baameiro, Nerea | |
dc.contributor.author | Santiago Varela, Maria | |
dc.contributor.author | Silva Rodríguez, Paula | |
dc.contributor.author | Blanco Teijeiro, María Jose | |
dc.contributor.author | Pardo Pérez, María | |
dc.contributor.author | Piñeiro Ces, Antonio | |
dc.date.accessioned | 2022-05-24T12:13:53Z | |
dc.date.available | 2022-05-24T12:13:53Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 1177-5467 | |
dc.identifier.other | https://www.ncbi.nlm.nih.gov/pubmed/32021081 | es |
dc.identifier.uri | http://hdl.handle.net/20.500.11940/16826 | |
dc.description.abstract | The detection of metastases in patients with a diagnosis of uveal melanoma (UM) is a controversial issue. While only 1% of the patients have detectable metastases at the time of diagnosis, up to 30% of them will develop liver metastases within 5 years of treatment. UM spreads hematogenously, therefore, blood biomarkers may be helpful for prognosis and monitoring the disease progression. Despite the great progress achieved thanks to the genetic analysis of UM biopsies, this is an invasive technique and is limited by the heterogeneity of the tumor. The present review considers the current understanding in the field regarding biomarkers for the diagnosis and prognosis of UM and its metastasis, primarily to the liver. General covered topics include non-conventional markers such as proteins previously identified in cutaneous melanoma and UM cell lines, circulating tumor cells, microRNAs (miRNA), and circulating DNA, and how each may be critical in the development of novel blood biomarkers for UM. | en |
dc.rights | Atribución-NoComercial 4.0 Internacional | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | |
dc.title | Blood Biomarkers of Uveal Melanoma: Current Perspectives | en |
dc.type | Journal Article | es |
dc.authorsophos | Bande Rodríguez, Manuel F;Fernandez Marta, Beatriz;Lago Baameiro, Nerea;Santiago-Varela, Maria;Silva-Rodríguez, Paula;Blanco-Teijeiro, María Jose;Pardo Perez, Maria;Piñeiro Ces, Antonio | |
dc.identifier.doi | 10.2147/OPTH.S199064 | |
dc.identifier.pmid | 32021081 | |
dc.identifier.sophos | 41689 | |
dc.issue.number | 157-169 | es |
dc.journal.title | Clinical Opthalmology | es |
dc.organization | Servizo Galego de Saúde::Dirección Xeral de Asistencia Sanitaria::Fundación Pública Galega de Medicina Xenómica | es |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Oftalmoloxía | es |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS) | es |
dc.relation.publisherversion | https://www.dovepress.com/getfile.php?fileID=55507 | es |
dc.rights.accessRights | openAccess | |
dc.subject.keyword | FPGMX | es |
dc.subject.keyword | CHUS | es |
dc.subject.keyword | IDIS | es |
dc.typefides | Artículo de Revisión | es |
dc.typesophos | Artículo de Revisión | es |
dc.volume.number | 14 | es |