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dc.contributor.authorBande Rodriguez, Manuel Francisco 
dc.contributor.authorFernández Marta, Beatriz
dc.contributor.authorLago Baameiro, Nerea
dc.contributor.authorSantiago Varela, Maria 
dc.contributor.authorSilva Rodríguez, Paula
dc.contributor.authorBlanco Teijeiro, María Jose 
dc.contributor.authorPardo Pérez, María 
dc.contributor.authorPiñeiro Ces, Antonio 
dc.date.accessioned2022-05-24T12:13:53Z
dc.date.available2022-05-24T12:13:53Z
dc.date.issued2020
dc.identifier.issn1177-5467
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/32021081es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/16826
dc.description.abstractThe detection of metastases in patients with a diagnosis of uveal melanoma (UM) is a controversial issue. While only 1% of the patients have detectable metastases at the time of diagnosis, up to 30% of them will develop liver metastases within 5 years of treatment. UM spreads hematogenously, therefore, blood biomarkers may be helpful for prognosis and monitoring the disease progression. Despite the great progress achieved thanks to the genetic analysis of UM biopsies, this is an invasive technique and is limited by the heterogeneity of the tumor. The present review considers the current understanding in the field regarding biomarkers for the diagnosis and prognosis of UM and its metastasis, primarily to the liver. General covered topics include non-conventional markers such as proteins previously identified in cutaneous melanoma and UM cell lines, circulating tumor cells, microRNAs (miRNA), and circulating DNA, and how each may be critical in the development of novel blood biomarkers for UM.en
dc.rightsAtribución-NoComercial 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.titleBlood Biomarkers of Uveal Melanoma: Current Perspectivesen
dc.typeJournal Articlees
dc.authorsophosBande Rodríguez, Manuel F;Fernandez Marta, Beatriz;Lago Baameiro, Nerea;Santiago-Varela, Maria;Silva-Rodríguez, Paula;Blanco-Teijeiro, María Jose;Pardo Perez, Maria;Piñeiro Ces, Antonio
dc.identifier.doi10.2147/OPTH.S199064
dc.identifier.pmid32021081
dc.identifier.sophos41689
dc.issue.number157-169es
dc.journal.titleClinical Opthalmologyes
dc.organizationServizo Galego de Saúde::Dirección Xeral de Asistencia Sanitaria::Fundación Pública Galega de Medicina Xenómicaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Oftalmoloxíaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)es
dc.relation.publisherversionhttps://www.dovepress.com/getfile.php?fileID=55507es
dc.rights.accessRightsopenAccess
dc.subject.keywordFPGMXes
dc.subject.keywordCHUSes
dc.subject.keywordIDISes
dc.typefidesArtículo de Revisiónes
dc.typesophosArtículo de Revisiónes
dc.volume.number14es


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Atribución-NoComercial 4.0 Internacional
Except where otherwise noted, this item's license is described as Atribución-NoComercial 4.0 Internacional