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dc.contributor.authorAlemany-Navarro, María
dc.contributor.authorCruz, Raquel
dc.contributor.authorReal, Eva
dc.contributor.authorSegalàs, Cinto
dc.contributor.authorBertolín, Sara
dc.contributor.authorRabionet, Raquel
dc.contributor.authorCarracedo Álvarez, Ángel
dc.contributor.authorMenchón, Jose M
dc.contributor.authorAlonso, Pino
dc.date.accessioned2022-05-24T12:14:04Z
dc.date.available2022-05-24T12:14:04Z
dc.date.issued2020
dc.identifier.issn2158-3188
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/32424139es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/16830
dc.description.abstractThe multidimensional nature of obsessive-compulsive disorder (OCD) has been consistently reported. Clinical and biological characteristics have been associated with OCD dimensions in different ways. Studies suggest the existence of specific genetic bases for the different OCD dimensions. In this study, we analyze the genomic markers, genes, gene ontology and biological pathways associated with the presence of aggressive/checking, symmetry/order, contamination/cleaning, hoarding, and sexual/religious symptoms, as assessed via the Dimensional Yale-Brown Obsessive Compulsive Scale (DY-BOCS) in 399 probands. Logistic regression analyses were performed at the single-nucleotide polymorphism (SNP) level. Gene-based and enrichment analyses were carried out for common (SNPs) and rare variants. No SNP was associated with any dimension at a genome-wide level (p < 5 x 10(-8)). Gene-based analyses showed one gene to be associated with hoarding (SETD3, p = 1.89 x 10(-08)); a gene highly expressed in the brain and which plays a role in apoptotic processes and transcriptomic changes, and another gene associated with aggressive symptoms (CPE; p = 4.42 x 10(-6)), which is involved in neurotrophic functions and the synthesis of peptide hormones and neurotransmitters. Different pathways or biological processes were represented by genes associated with aggressive (zinc ion response and lipid metabolism), order (lipid metabolism), sexual/religious (G protein-mediated processes) and hoarding (metabolic processes and anion transport) symptoms after FDR correction; while no pathway was associated with contamination. Specific genomic bases were found for each dimension assessed, especially in the enrichment analyses. Further research with larger samples and different techniques, such as next-generation sequencing, are needed to better understand the differential genetics of OCD dimensions.en
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.meshAggression*
dc.subject.meshHumans*
dc.subject.meshSexual Behavior*
dc.titleLooking into the genetic bases of OCD dimensions: a pilot genome-wide association studyen
dc.typeJournal Articlees
dc.authorsophosAlemany-Navarro, María;Cruz, Raquel;Real, Eva;Segalàs, Cinto;Bertolín, Sara;Rabionet, Raquel;Carracedo, Ángel;Menchón, Jose M;Alonso, Pino
dc.identifier.doi10.1038/s41398-020-0804-z
dc.identifier.pmid32424139
dc.identifier.sophos41786
dc.issue.number1es
dc.journal.titleTranslational psychiatryes
dc.organizationServizo Galego de Saúde::Dirección Xeral de Asistencia Sanitaria::Fundación Pública Galega de Medicina Xenómicaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)es
dc.rights.accessRightsopenAccess
dc.subject.decsagresión*
dc.subject.decshumanos*
dc.subject.decsconducta sexual*
dc.subject.keywordFPGMXes
dc.subject.keywordIDISes
dc.typefidesArtículo Originales
dc.typesophosArtículo Originales
dc.volume.number10es


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