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The Road so Far in Colorectal Cancer Pharmacogenomics: Are We Closer to Individualised Treatment?
dc.contributor.author | Santos Simoes, Ana Rita | |
dc.contributor.author | Fernández Rozadilla, Ceres | |
dc.contributor.author | Maronas, O | |
dc.contributor.author | Carracedo Álvarez, Ángel | |
dc.date.accessioned | 2022-05-24T12:14:13Z | |
dc.date.available | 2022-05-24T12:14:13Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 2075-4426 | |
dc.identifier.other | https://www.ncbi.nlm.nih.gov/pubmed/33228198 | es |
dc.identifier.uri | http://hdl.handle.net/20.500.11940/16832 | |
dc.description.abstract | In recent decades, survival rates in colorectal cancer have improved greatly due to pharmacological treatment. However, many patients end up developing adverse drug reactions that can be severe or even life threatening, and that affect their quality of life. These remain a limitation, as they may force dose reduction or treatment discontinuation, diminishing treatment efficacy. From candidate gene approaches to genome-wide analysis, pharmacogenomic knowledge has advanced greatly, yet there is still huge and unexploited potential in the use of novel technologies such as next-generation sequencing strategies. This review summarises the road of colorectal cancer pharmacogenomics so far, presents considerations and directions to be taken for further works and discusses the path towards implementation into clinical practice. | en |
dc.rights | Atribución 4.0 Internacional | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.title | The Road so Far in Colorectal Cancer Pharmacogenomics: Are We Closer to Individualised Treatment? | en |
dc.type | Journal Article | es |
dc.authorsophos | Simoes, AR Fernandez-Rozadilla, C Maronas, O Carracedo, A | |
dc.identifier.doi | 10.3390/jpm10040237 | |
dc.identifier.pmid | 33228198 | |
dc.identifier.sophos | 41938 | |
dc.issue.number | 4 | es |
dc.journal.title | JOURNAL OF PERSONALIZED MEDICINE | es |
dc.organization | Servizo Galego de Saúde::Dirección Xeral de Asistencia Sanitaria::Fundación Pública Galega de Medicina Xenómica | es |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS) | es |
dc.rights.accessRights | openAccess | |
dc.subject.keyword | FPGMX | es |
dc.subject.keyword | IDIS | es |
dc.typefides | Artículo de Revisión | es |
dc.typesophos | Artículo de Revisión | es |
dc.volume.number | 10 | es |