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dc.contributor.authorGago Dominguez, Manuela
dc.contributor.authorMatabuena M
dc.contributor.authorRedondo CM
dc.contributor.authorPatel SP
dc.contributor.authorCarracedo Álvarez, Ángel
dc.contributor.authorPonte SM
dc.contributor.authorMartinez ME
dc.contributor.authorCastelao JE
dc.date.accessioned2022-05-24T12:15:05Z
dc.date.available2022-05-24T12:15:05Z
dc.date.issued2020
dc.identifier.issn2045-2322
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/32764699es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/16836
dc.description.abstractMultiple studies have found the neutrophil to lymphocyte ratio (NLR) to be associated with adverse breast cancer (BC) prognosis and survival. Very limited data exist on the role of NLR and risk of BC. The BREOGAN study is a population-based case-control study conducted in Galicia, Spain. We examined the WBC- and NLR-BC relationships. The risk of BC increased with increasing levels of neutrophils percentage (NE%) (multivariable OR for the highest category (95% CI) = 2.14 (1.39-3.32), P-trend < 0.001) and of the NLR (multivariable OR for the highest category (95% CI) = 1.93 (1.26-2.97), P-trend < 0.001). Lymphocytes absolute (L#) and percentage (L%) were associated with a decreased risk of BC (multivariable OR for the highest category (95% CI) = 0.54 (0.35-0.83), and 0.51 (0.33-0.79), P-trend = 0.001 and < 0.001, respectively). The NLR-BC association was more pronounced among Luminal A BC (multivariable OR for the highest category (95% CI) = 2.00 (1.17-3.45), P-trend < 0.001), HER2-negative BC (multivariable OR for the highest category (95% CI) = 1.87 (1.16-3.02), P-trend < 0.001), and those with high total cholesterol and low H2O2 levels.en
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.meshRisk*
dc.subject.meshMenopause*
dc.subject.meshAdult*
dc.subject.meshBreast Neoplasms*
dc.subject.meshNeoplasm Staging*
dc.subject.meshMiddle Aged*
dc.subject.meshLymphocytes*
dc.subject.meshAdolescent*
dc.subject.meshLymphocyte Count*
dc.subject.meshNeoplasm Grading*
dc.subject.meshNeutrophils*
dc.subject.meshPregnancy*
dc.subject.meshHumans*
dc.subject.meshCase-Control Studies*
dc.titleNeutrophil to lymphocyte ratio and breast cancer risk: analysis by subtype and potential interactionsen
dc.typeJournal Articlees
dc.authorsophosGago-Dominguez, M Matabuena, M Redondo, CM Patel, SP Carracedo, A Ponte, SM Martinez, ME Castelao, JE
dc.identifier.doi10.1038/s41598-020-70077-z
dc.identifier.pmid32764699
dc.identifier.sophos41952
dc.issue.number1es
dc.journal.titleScientific Reportses
dc.organizationServizo Galego de Saúde::Dirección Xeral de Asistencia Sanitaria::Fundación Pública Galega de Medicina Xenómicaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)es
dc.rights.accessRightsopenAccess
dc.subject.decsestudios de casos y controles*
dc.subject.decsmenopausia*
dc.subject.decsestadificación de neoplasias*
dc.subject.decsneoplasias de la mama*
dc.subject.decsrecuento de linfocitos*
dc.subject.decsmediana edad*
dc.subject.decsembarazo*
dc.subject.decsadulto*
dc.subject.decshumanos*
dc.subject.decsriesgo*
dc.subject.decsgradación neoplásica*
dc.subject.decsadolescente*
dc.subject.decslinfocitos*
dc.subject.decsneutrófilos*
dc.subject.keywordFPGMXes
dc.subject.keywordIDISes
dc.typefidesArtículo Originales
dc.typesophosArtículo Originales
dc.volume.number10es


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