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dc.contributor.authorCarpintero Fernández, Paula
dc.contributor.authorVarela Eirín, Marta
dc.contributor.authorGarcía Yuste, Alejandro
dc.contributor.authorLópez Díaz, Iñaki
dc.contributor.authorCaeiro Rey, José Ramón 
dc.contributor.authorMayán Santos, María Dolores
dc.date.accessioned2022-11-24T12:42:02Z
dc.date.available2022-11-24T12:42:02Z
dc.date.issued2022-03-15
dc.identifier.urihttp://hdl.handle.net/20.500.11940/17065
dc.description.abstractOsteoarthritis (OA) is the most common joint disease. In the last years, the research community has focused on understanding the molecular mechanisms that led to the pathogenesis of the disease, trying to identify different molecular and clinical phenotypes along with the discovery of new therapeutic opportunities. Different types of cell-to-cell communication mechanisms have been proposed to contribute to OA progression, including mechanisms mediated by connexin43 (Cx43) channels or by small extracellular vesicles. Furthermore, changes in the chondrocyte phenotype such as cellular senescence have been proposed as new contributors of the OA progression, changing the paradigm of the disease. The use of different drugs able to restore chondrocyte phenotype, to reduce cellular senescence and senescence-associated secretory phenotype components, and to modulate ion channel activity or Cx43 appears to be promising therapeutic strategies for the different types of OA. In this review, we aim to summarize the current knowledge in OA phenotypes related with aging and tissue damage and the new therapeutic opportunities currently available.es
dc.description.sponsorshipEuropean Regional Development Fund, ‘‘A way of making Europe’’ from the European Union (to María D. Mayán): grant PI19/ 00145es
dc.description.sponsorshipXunta de Galicia (IN607B2020/12) (to María D. Mayán)es
dc.description.sponsorshipH2020, Future and Emerging Technologies (Grant 858014 ‘‘PANACHE’’) to María D. Mayánes
dc.description.sponsorshipEuroNAnoMedes
dc.description.sponsorshipJoint Transnational Call for proposals for European Innovative Research & Trchnological Development Projects in Nanomedicine, ISCIII (AC21_2/00026) to María D. Mayán.es
dc.description.sponsorshipInstituto de Salud Carlos III (ISCIII)es
dc.language.isoenges
dc.subject.meshTherapeutics*
dc.subject.meshCartilage, Articular*
dc.subject.meshConnexin 43*
dc.subject.meshChondrocytes*
dc.titleOsteoarthritis: Mechanistic Insights, Senescence, and Novel Therapeutic Opportunitieses
dc.typeArtigoes
dc.rights.holderEl editores
dc.identifier.doihttps://doi.org/10.1089/bioe.2021.0039
dc.issue.number1es
dc.journal.titleBioelectricityes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Biomédica da Coruña (INIBIC)es
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Traumatoloxíaes
dc.page.initial39es
dc.page.final47es
dc.relation.projectIDXunta de Galicia/IN607B2020/10es
dc.relation.publisherversionhttps://www.liebertpub.com/doi/10.1089/bioe.2021.0039es
dc.rights.accessRightsembargoedAccesses
dc.subject.decsconexina 43*
dc.subject.decsterapéutica*
dc.subject.decscartílago articular*
dc.subject.decscondrocitos*
dc.subject.keywordINIBICes
dc.subject.keywordCHUSes
dc.typefidesArtigo Científico (inclue Orixinal, Orixinal breve, Revisión Sistemática e Meta-análisis)es
dc.typesophosArtículo Originales
dc.volume.number4es


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