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dc.contributor.authorMontes Martínez, Ariadna
dc.contributor.authorPérez Pampín, Eva 
dc.contributor.authorCalaza Cabanas, Manuel
dc.contributor.authorGómez-Reino Carnota, Juan Jesús 
dc.contributor.authorGonzález Martínez-Pedrayo, Antonio 
dc.date.accessioned2023-06-21T07:39:30Z
dc.date.available2023-06-21T07:39:30Z
dc.date.issued2012-10
dc.identifier.issn0004-3591
dc.identifier.otherhttps://pubmed.ncbi.nlm.nih.gov/22674012/es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/17703
dc.description.abstract[EN] Objective. To determine whether the anti– citrullinated vimentin peptide 60–75 (anti–Cit-vimentin) and the immunodominant anti–citrullinated -enolase peptide 1 (anti–CEP-1) antibodies are associated with subsets of patients with rheumatoid arthritis (RA) independently of the associations between anti–cyclic citrullinated peptide (anti-CCP) antibodies and clinical features of RA. Methods. The 3 antibody types were quantified by enzyme-linked immunosorbent assay (ELISA) in serum samples from 521 patients with RA and 173 healthy controls of Spanish ancestry. Genotypes for HLA–DRB1 alleles and rs2476601 in PTPN22 were available for these patients and controls plus an addi- tional 106 healthy controls. A combined analysis of the 3 antibodies was conducted using stratified contingency tables and logistic regression models. Results. A differential, particularly strong, and independent association was observed between the pres- ence of anti–Cit-vimentin antibodies and the presence of shared epitope (SE) alleles, specifically in patients carrying 2 SE alleles, and between the presence of anti– Cit-vimentin antibodies and the prevalence of joint erosion. Associations were observed between anti– CEP-1 positivity and the presence of HLA–DRB1 and PTPN22 risk alleles and their additive interaction. These associations were not accounted for by the anti- CCP status. Conclusion. Our results indicate that the 2 anti- bodies against citrullinated peptides analyzed in this study add specific information beyond that obtained with the anti-CCP status. They define subgroups of patients with RA in which genetic factors have different weight and there is an observed difference in the prev- alence of erosions.es
dc.description.sponsorshipFondo de Investigación Sanitaria del Instituto de Salud Carlos III (ISCIII)es
dc.description.sponsorshipEuropean Regional Development Fund of the European Uniones
dc.description.sponsorshipXunta de Galiciaes
dc.description.sponsorshipFundación Española de Reumatologíaes
dc.language.isoenges
dc.subject.meshEpitopes*
dc.subject.meshArthritis, Rheumatoid*
dc.subject.meshAutoantibodies*
dc.subject.meshGenetics*
dc.subject.meshVimentin*
dc.subject.meshCitrullination*
dc.subject.meshGenotype*
dc.subject.meshHLA-DRB1 Chains*
dc.titleAssociation of anti-citrullinated vimentin and anti-citrullinated α-enolase antibodies with subsets of rheumatoid arthritis.es
dc.typeArtigoes
dc.rights.holderWileyes
dc.bbddWOK*
dc.identifier.doi10.1002/art.34569
dc.identifier.essn1529-0131
dc.identifier.pmid22674012
dc.issue.number10es
dc.journal.titleArthritis and Rheumatologyes
dc.journal.titleARTHRITIS AND RHEUMATISM [ISSN:0004-3591]*
dc.organizationServizo Galego de Saúde::Áreas Sanitarias (A.S.)::Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)es
dc.page.initial3102es
dc.page.final3110es
dc.relation.projectIDISCIII/PI08/0744es
dc.relation.projectIDISCIII/RD08/0075/001es
dc.relation.projectIDISCIII/09/90744es
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/10.1002/art.34569es
dc.rights.accessRightsopenAccesses
dc.subject.decsautoanticuerpos*
dc.subject.decsvimentina*
dc.subject.decsgenotipo*
dc.subject.decscadenas HLA-DRB1*
dc.subject.decsepítopos*
dc.subject.decsgenética*
dc.subject.decsartritis reumatoide*
dc.subject.keywordanti-carbamylated protein antibodieses
dc.subject.keywordenolasees
dc.subject.keywordbone erosiones
dc.subject.keywordPTPN22es
dc.subject.keywordIDISes
dc.subject.keywordCHUSes
dc.typefidesArtigo Científico (inclue Orixinal, Orixinal breve, Revisión Sistemática e Meta-análisis)es
dc.typesophosArtículo Originales
dc.volume.number64es


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